Zobrazeno 1 - 8 of 8 pro vyhledávání: '"D J, Esdaile"'
1
An evaluation of the proposed OECD testing strategy for skin corrosion
Autor: A P, Worth, J H, Fentem, M, Balls, P A, Botham, R D, Curren, L K, Earl, D J, Esdaile
Publikováno v: Alternatives to laboratory animals : ATLA. 26(5)
The use of testing strategies which incorporate a range of alternative methods and which use animals only as a last resort is widely considered to provide a reliable way of predicting chemical toxicity while minimising animal testing. The widespread
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89c13fef7363f2453b3c2de6db167ae2
https://pubmed.ncbi.nlm.nih.gov/26042494
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2
Eye Irritation Testing: The Way Forward. The Report and Recommendations of ECVAM Workshop 34
Autor: M, Balls, N, Berg, L H, Bruner, R D, Curren, O, de Silva, L K, Earl, D J, Esdaile, J H, Fentem, M, Liebsch, Y, Ohno, M K, Prinsen, H, Spielmann, A P, Worth
Publikováno v: Alternatives to laboratory animals : ATLA. 27(1)
This is the report of the thirty-fourth of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). ECVAM's main goal, as defined in 1993 by its Scientific Advisory Committee, is to promote the scienti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d88eb6c242e1d742cfb602e4ed28a912
https://pubmed.ncbi.nlm.nih.gov/25423402
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3
Molecular profiling of non-genotoxic hepatocarcinogenesis using differential display reverse transcription-polymerase chain reaction (ddRT-PCR)
Autor: D. J. Esdaile, John C. Rockett, G. Gordon Gibson
Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 22:329-333
The technique of differential display reverse transcription-polymerase chain reaction (ddRT-PCR) has been used to produce unique profiles of up-regulated and down-regulated gene expression in the liver of male Wistar rats following short term exposur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e91e076d97e91751b027b29ac5745e
https://doi.org/10.1007/bf03190966
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4
Comparison of the human skin grafted onto nude mouse model with in vivo and in vitro models in the prediction of percutaneous penetration of three lipophilic pesticides
Autor: Anne-Pascale Luzy, D. J. Esdaile, Annabelle Capt, O. Blanck
Publikováno v: Regulatory toxicology and pharmacology : RTP. 47(3)
The evaluation of the degree of percutaneous penetration of agrochemicals is a key part of risk assessment for operators. The availability of suitable and predictive experimental models is crucial, in particular in the case of lipophilic compounds wh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1240cc52e086741bb76dbc936335b47b
https://pubmed.ncbi.nlm.nih.gov/17239512
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5
A multi-laboratory evaluation of a common in vitro pepsin digestion assay protocol used in assessing the safety of novel proteins
Autor: Richard E. Goodman, H. Y. Steiner, Laura Privalle, Sue MacIntosh, N. Hadfield, J. R. Heylings, Reiko Teshima, Gary A. Bannon, C. Hatzos, J. Zawodny, Michael P. Holsapple, Elena A. Rice, D. J. Esdaile, B. Henry, Susan L. Hefle, Timothy D. Landry, M. Aalbers, C. M. Glatt, Gregory S. Ladics, Karluss Thomas, Michael J. Bartels, T. J. Fu, C. Herouet, Michael R. Woolhiser, Rebecca J. Dearman, R. van Ree
Publikováno v: Regulatory toxicology and pharmacology, 39(2), 87-98. Academic Press Inc.
Rationale. Evaluation of the potential allergenicity of proteins derived from genetically modified foods has involved a weight of evidence approach that incorporates an evaluation of protein digestibility in pepsin. Currently, there is no standardize
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9faa94ddfdd27124aec7a86975037ddb
https://pubmed.ncbi.nlm.nih.gov/15041142
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8
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