Zobrazeno 1 - 10
of 24
pro vyhledávání: '"D J, Carey"'
Common genetic variants identify targets for COVID-19 and individuals at high risk of severe disease
Autor:
J E, Horowitz, J A, Kosmicki, A, Damask, D, Sharma, G H L, Roberts, A E, Justice, N, Banerjee, M V, Coignet, A, Yadav, J B, Leader, A, Marcketta, D S, Park, R, Lanche, E, Maxwell, S C, Knight, X, Bai, H, Guturu, D, Sun, A, Baltzell, F S P, Kury, J D, Backman, A R, Girshick, C, O'Dushlaine, S R, McCurdy, R, Partha, A J, Mansfield, D A, Turissini, A H, Li, M, Zhang, J, Mbatchou, K, Watanabe, L, Gurski, S E, McCarthy, H M, Kang, L, Dobbyn, E, Stahl, A, Verma, G, Sirugo, M D, Ritchie, M, Jones, S, Balasubramanian, K, Siminovitch, W J, Salerno, A R, Shuldiner, D J, Rader, T, Mirshahi, A E, Locke, J, Marchini, J D, Overton, D J, Carey, L, Habegger, M N, Cantor, K A, Rand, E L, Hong, J G, Reid, C A, Ball, A, Baras, G R, Abecasis, M A, Ferreira
Publikováno v:
medRxiv
The need to identify and effectively treat COVID-19 cases at highest risk for severe disease remains critical. We identified five common genetic loci (two novel) that modulate both COVID-19 susceptibility and severity, implicating TMPRSS2, IFNAR2, CC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0280def6ca331ba9b219c4a4db248c7d
https://europepmc.org/articles/PMC7899471/
https://europepmc.org/articles/PMC7899471/
Publikováno v:
The Journal of biological chemistry. 275(36)
Previously, we reported the isolation of a heparan sulfate-binding collagenous protein, p200, that is expressed by Schwann cells in developing peripheral nerves ((1996) J. Biol. Chem. 271, 13844-13853; (1999) J. Neurosci. Res. 56, 284-294). Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb2666771dbc636be107315c6f3aacfd
https://pubmed.ncbi.nlm.nih.gov/10852920
https://pubmed.ncbi.nlm.nih.gov/10852920
Autor:
M A, Chernousov, D J, Carey
Publikováno v:
Histology and histopathology. 15(2)
The major cellular constituents of the mammalian peripheral nervous system are neurons (axons) and Schwann cells. During peripheral nerve development Schwann cells actively deposit extracellular matrix (ECM), comprised of basal lamina sheets that sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b2b52e79529900d3b1a98328059b795
https://pubmed.ncbi.nlm.nih.gov/10809381
https://pubmed.ncbi.nlm.nih.gov/10809381
Publikováno v:
Journal of neuroscience research. 56(3)
Previously we reported that cultured rat Schwann cells secrete p200, a collagen-like heparin-binding adhesive glycoprotein with a restricted pattern of expression. Here we report that p200 is secreted as a stable trimer, but only after treatment of S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3791d4ec9cf47b71120290307b7d89a6
https://pubmed.ncbi.nlm.nih.gov/10336258
https://pubmed.ncbi.nlm.nih.gov/10336258
Publikováno v:
European journal of cell biology. 71(2)
We identified previously a glycosylphosphatidylinositol (GPI)-anchored heparan sulfate proteoglycan (HSPG) releasable by phosphatidylinositol-specific phospholipase C (PI-PLC) on the surface of differentiated skeletal muscle cells (Campos et al., Eur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4cdab65a0a565cbda2b11cb2838c66c0
https://pubmed.ncbi.nlm.nih.gov/8905294
https://pubmed.ncbi.nlm.nih.gov/8905294
Publikováno v:
The Journal of biological chemistry. 271(25)
Syndecan-1 is a member of a gene family of multifunctional transmembrane heparan sulfate proteoglycans that bind a variety of extracellular ligands and possess highly conserved non-catalytic cytoplasmic domains. It has been shown that antibody-mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3dd92e985ab58594e3064aa44627cbc5
https://pubmed.ncbi.nlm.nih.gov/8662979
https://pubmed.ncbi.nlm.nih.gov/8662979
Autor:
D J, Carey
Publikováno v:
Perspectives on developmental neurobiology. 3(4)
N-syndecan is a member of the syndecan family of transmembrane heparan sulfate proteoglycans that was cloned initially from neonatal rat Schwann cells and is the principal syndecan expressed during early postnatal development in the central and perip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d20da040a9aa17353ecd4b8b7c6c979
https://pubmed.ncbi.nlm.nih.gov/9117264
https://pubmed.ncbi.nlm.nih.gov/9117264
Publikováno v:
The Journal of biological chemistry. 268(25)
Rat aortic vascular smooth muscle (VSM) cells synthesize the transmembrane proteoglycan syndecan (Cizmeci-Smith, G., Asundi, V., Stahl, R. C., Teichman, L. J., Chernousov, M., Cowan, K., and Carey, D. J. (1992) J. Biol. Chem. 267, 15729-15736). The p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64acd7ebb49c5e7147d8a2de7324a5d3
https://pubmed.ncbi.nlm.nih.gov/8360168
https://pubmed.ncbi.nlm.nih.gov/8360168
Publikováno v:
The Journal of biological chemistry. 267(22)
cDNA encoding the core protein of rat syndecan was cloned from a neonatal rat aortic cDNA library by polymerase chain reaction amplification. Expression of syndecan mRNA in rat aortic vascular smooth muscle (VSM) cells was demonstrated by reverse tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7116ee23aded9d1dc8ab365f3eaddea9
https://pubmed.ncbi.nlm.nih.gov/1639809
https://pubmed.ncbi.nlm.nih.gov/1639809
Publikováno v:
The Journal of Cell Biology
Schwann cells synthesize both hydrophobic and peripheral cell surface heparan sulfate proteoglycans (HSPGs). Previous analysis of the kinetics of radiolabeling suggested the peripheral HSPGs are derived from the membrane-anchored forms (Carey, D., an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5863e1aa84629498ee11700fcfbb7d35
https://pubmed.ncbi.nlm.nih.gov/2172260
https://pubmed.ncbi.nlm.nih.gov/2172260