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Therapeutic drug monitoring of atazanavir/ritonavir in pregnancy

Autor: L J, Else, V, Jackson, M, Brennan, D J, Back, S H, Khoo, S, Coulter-Smith, J S, Lambert

Publikováno v: HIV medicine. 15(10)

Pregnant women experience physiological changes during pregnancy that can have a significant impact on antiretroviral pharmacokinetics. Ensuring optimal plasma concentrations of antiretrovirals is essential for maternal health and to minimize the ris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9f1254e5fd3ff8e7205000b85bfdf3a
https://pubmed.ncbi.nlm.nih.gov/24825070

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Therapeutic drug monitoring of lopinavir/ritonavir in pregnancy

Autor: J S, Lambert, L J, Else, V, Jackson, J, Breiden, S, Gibbons, L, Dickinson, D J, Back, M, Brennan, E O, Connor, N, Boyle, C, Fleming, S, Coulter-Smith, S H, Khoo

Publikováno v: HIV medicine. 12(3)

The aim of the study was to determine total and unbound lopinavir (LPV) plasma concentrations in HIV-infected pregnant women receiving lopinavir/ritonavir (LPV/r tablet) undergoing therapeutic drug monitoring (TDM) during pregnancy and postpartum.Wom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a7cf7596202c76669e4e883febd230b2
https://pubmed.ncbi.nlm.nih.gov/20726906

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Cultured CD4T cells and primary human lymphocytes express hOATPs: intracellular accumulation of saquinavir and lopinavir

Autor: O, Janneh, R C, Hartkoorn, E, Jones, A, Owen, S A, Ward, R, Davey, D J, Back, S H, Khoo

Publikováno v: British journal of pharmacology. 155(6)

Drug efflux tranporters (P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP)) limit the cellular uptake of human immunodeficiency virus protease inhibitors but the contribution of influx transporters in cells that (over)express P-gp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6b446c18493ec83f5003c423e396cf3
https://pubmed.ncbi.nlm.nih.gov/19002102

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Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells

Autor: P, Martin, R, Riley, D J, Back, A, Owen

Publikováno v: British journal of pharmacology. 153(4)

Certain nuclear receptors (NRs) such as the constitutive androstane receptor (CAR), pregnane X receptor (PXR) and farnesoid X receptor (FXR) mediate induction of some cytochrome P450 enzymes and ABC transporters but conflicting reports exist. The pur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a3bd222777e9698f31a2ec9aa0cd7212
https://pubmed.ncbi.nlm.nih.gov/18037906

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Expression of P-glycoprotein and multidrug resistance-associated protein in healthy volunteers and HIV-infected patients

Autor: E R, Meaden, P G, Hoggard, B, Maher, S H, Khoo, D J, Back

Publikováno v: AIDS research and human retroviruses. 17(14)

Increased expression of the multidrug efflux transporters P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) has been suggested as a potential mechanism for decreased drug availability at certain intracellular sites that provide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09a4cf050ceb31c0d7b9a25ce42e554d
https://pubmed.ncbi.nlm.nih.gov/11602043

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The role of therapeutic drug monitoring in treatment of HIV infection

Autor: D J, Back, S H, Khoo, S E, Gibbons, C, Merry

Publikováno v: British journal of clinical pharmacology. 51(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::afa9621e9dbf17cdde99279d20fc2782
https://pubmed.ncbi.nlm.nih.gov/11318764

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The pharmacokinetics of methadone in HIV-positive patients receiving the non-nucleoside reverse transcriptase inhibitor efavirenz

Autor: S M, Clarke, F M, Mulcahy, J, Tjia, H E, Reynolds, S E, Gibbons, M G, Barry, D J, Back

Publikováno v: British journal of clinical pharmacology. 51(3)

Methadone is predominantly metabolized by cytochrome P450 3A4 and the non nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz is a recognized inducer of this enzyme. We evaluated the pharmacokinetics of methadone in the presence and absence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a3f0e57d28b180dd4a0026a630ed7a7
https://pubmed.ncbi.nlm.nih.gov/11298066

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Elevated alpha-1-acid glycoprotein reduces the volume of distribution and systemic clearance of saquinavir

Autor: J W, Holladay, M J, Dewey, B B, Michniak, H, Wiltshire, D L, Halberg, P, Weigl, Z, Liang, K, Halifax, W E, Lindup, D J, Back

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(3)

The purpose of this study was to characterize the relationship between plasma protein binding and the pharmacokinetic disposition of saquinavir during a normal and elevated alpha-1-acid glycoprotein condition. The extent of plasma binding of [14C]saq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::21384812e993bf69a203b2200a103daa
https://pubmed.ncbi.nlm.nih.gov/11181499

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