Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic Acinar Cells Leads to Chronic Pancreatitis

Autor: Guy E. Groblewski, Kali Deans, Michelle M. Cooley, Luigi Puglielli, Stephen J. Pandol, Aurelia Lugea, Yajing Peng, Diana D. H. Thomas

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 725-738 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Maintaining endoplasmic reticulum (ER) proteostasis is essential for pancreatic acinar cell function. Under conditions of severe ER stress, activation of pathogenic unfolded protein response pathways plays a central role in the deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff62c51953438aac0781c359ade92ac
https://doi.org/10.1016/j.jcmgh.2020.10.008

Transgenic expression of GFP-LC3 perturbs autophagy in exocrine pancreas and acute pancreatitis responses in mice

Autor: Dustin L. Dillon, Anna S. Gukovskaya, Sophie Gretler, Guy E. Groblewski, Ilya Gukovsky, Wenzhuo Jia, Conner L. Holthaus, Olga A. Mareninova, Michael Pimienta, Diana D. H. Thomas

Publikováno v: Autophagy

Pancreatitis is a common, sometimes fatal, disease of exocrine pancreas, initiated by damaged acinar cells. Recent studies implicate disordered macroautophagy/autophagy in pancreatitis pathogenesis. ATG8/LC3 protein is critical for autophagosome form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad1a87568b51d4132a786fc416359f3
https://pubmed.ncbi.nlm.nih.gov/31942816

Mo1375 IMPAIRED LONG-CHAIN FATTY ACID METABOLISM IN ACINAR CELLS LEADS TO SEVERE PANCREATITIS

Autor: Sicong Tian, David W. Nelson, Mei-I Yen, Katelyn Cassel, C-L Eric Yen, Guy E. Groblewski, Diana D. H. Thomas, Mitchell T. Lavarias

Publikováno v: Gastroenterology. 158:S-868

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a676f2be2035208a25cd6f777d4029b6
https://doi.org/10.1016/s0016-5085(20)32852-3

Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells

Autor: Diana D. H. Thomas, Michelle M. Cooley, Scott W. Messenger, Fred S. Gorelick, Michelle A. Falkowski, Luis A. Fernandez, Guy E. Groblewski, Benjamin K. August, Elaina K. Jones

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 6, Pp 695-709 (2015)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims: Pancreatic acinar cells have an expanded apical endosomal system, the physiologic and pathophysiologic significance of which is still emerging. Phosphatidylinositol-3,5-bisphosphate [PI(3,5)P2] is an essential phospholipid generate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5e6298034e5ed01785c0f1e3ea0524

‘The child is father of the man’: Alfred Drury and temporality

Autor: Ben D. H. Thomas

Publikováno v: Sculpture Journal. 24:55-72

This article takes a thematic approach to analyse aspects of the sculpture of Alfred Drury (1856–1944), notably his concern with temporality, both as an iconographical leitmotif of his works, and as a characteristic of the ‘realistic allegory’

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347c1ee87bbcc9096abacf2f65604281
https://doi.org/10.3828/sj.2015.24.1.5