Zobrazeno 1 - 10
of 286
pro vyhledávání: '"D H Sachs"'
Publikováno v:
The Journal of Immunology. 162:550-559
Studies utilizing partially inbred miniature swine have demonstrated that a short course of cyclosporin A leads to indefinite survival of two haplotype class I mismatched renal allografts. In the present study, we have examined peripheral regulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d7f4c96e198dad85673e0e98321a4f
https://doi.org/10.4049/jimmunol.162.1.550
https://doi.org/10.4049/jimmunol.162.1.550
Publikováno v:
The Journal of Immunology. 159:2318-2326
Elucidation of the mechanism of the immune response against transplanted porcine tissue is critical for the success of xenografting in humans. Both human T cells and NK cells recognize MHC Ags, and human receptors may bind to MHC Ags across species b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bb335411670b1061d29f0a02f4d5cf9
https://doi.org/10.4049/jimmunol.159.5.2318
https://doi.org/10.4049/jimmunol.159.5.2318
Publikováno v:
The Journal of Immunology. 159:2100-2107
Specific tolerance to discordant xenogeneic donors can be achieved by grafting of fetal pig thymic and liver tissue (FP THY/LIV) to T cell and NK cell-depleted, thymectomized (ATX) mice. Mouse CD4+ T cells develop in FP THY/LIV grafts, and demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dba4e77e91d63ce4a6bf39f03f97d80b
https://doi.org/10.4049/jimmunol.159.5.2100
https://doi.org/10.4049/jimmunol.159.5.2100
Autor:
Y Zhao, J A Fishman, J J Sergio, J L Oliveros, D A Pearson, G L Szot, R A Wilkinson, J S Arn, D H Sachs, M Sykes
Publikováno v:
The Journal of Immunology. 158:1641-1649
Donor-specific tolerance can be induced across a discordant xenogeneic barrier in T/NK cell-depleted, thymectomized (ATX) B10 mice by grafting of fetal pig thymic and liver tissue (FP THY/LIV) under the kidney capsule. We have now examined the phenot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d00466e8cbb252d4da5f37c1d1852a42
https://doi.org/10.4049/jimmunol.158.4.1641
https://doi.org/10.4049/jimmunol.158.4.1641
Publikováno v:
The Journal of Immunology. 155:5249-5256
Partially inbred, MHC homozygous miniature swine have been used to study the nature of the human xenogeneic cellular immune response to swine Ags in vitro. Human T cells responded to xeno-MHC Ags in MLR at least as well as they did to allo-MHC Ags an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dd2de81ee29111a4491207c0623dbf4
https://doi.org/10.4049/jimmunol.155.11.5249
https://doi.org/10.4049/jimmunol.155.11.5249
Publikováno v:
The Journal of Immunology. 154:1587-1595
To investigate the potential role for gene therapy in induction of tolerance to solid organ grafts, we used a murine model based on the introduction of an allogeneic MHC class I gene (H-2Kb) into hematopoietic cells of congenic animals differing only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd8ad33b4c8c9763bc528a386426ab9b
https://doi.org/10.4049/jimmunol.154.4.1587
https://doi.org/10.4049/jimmunol.154.4.1587
Publikováno v:
The Journal of Immunology. 153:4788-4797
Indefinite tolerance to kidney allografts across a two-haplotype class I disparity can be induced in miniature swine in 100% of cases by a short course of cyclosporin A (CyA). Without CyA, all recipients reject kidney allografts within 2 wk. These an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c855c637d94dd71e219d646d2b00239
https://doi.org/10.4049/jimmunol.153.10.4788
https://doi.org/10.4049/jimmunol.153.10.4788
Publikováno v:
Immunological Reviews. 141:245-276
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc82a86ef888b04401977edcca1a991c
https://doi.org/10.1111/j.1600-065x.1994.tb00880.x
https://doi.org/10.1111/j.1600-065x.1994.tb00880.x
Publikováno v:
The Journal of Immunology. 151:1365-1370
MHC class II polymorphism is well documented whereas only minimal polymorphism has been reported for the CD4 molecule with which it interacts. We report on the structural basis of an allelic polymorphism of the CD4 molecule in miniature swine. Eleven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de3483f108314984eb90e0a8d58c4c6c
https://doi.org/10.4049/jimmunol.151.3.1365
https://doi.org/10.4049/jimmunol.151.3.1365
Publikováno v:
Blood. 81:2460-2465
The possibility of inducing transplantation tolerance by somatic gene transfer is under investigation in our miniature swine model. As a crucial step in this project, we have used a retroviral vector engineered to express both a drug-resistance gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f16ab79a295395adeae0d6974feccb
https://doi.org/10.1182/blood.v81.9.2460.bloodjournal8192460
https://doi.org/10.1182/blood.v81.9.2460.bloodjournal8192460