CYP1A1 specificity of Verlukast epoxidation in mice, rats, rhesus monkeys, and humans

Autor: S J, Grossman, E G, Herold, J M, Drey, D W, Alberts, D R, Umbenhauer, D H, Patrick, D, Nicoll-Griffith, N, Chauret, J A, Yergey

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 21(6)

It has previously been shown that Verlukast is converted to Verlukast dihydrodiol in microsomes from beta-naphthoflavone (BNF)-treated, but not uninduced Swiss Webster mice and Sprague-Dawley rats. We have examined the involvement of CYP1A1 in this r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::721c8ecd07785ec50095f0db3cec2e28
https://pubmed.ncbi.nlm.nih.gov/7905381

Abstracts of scientific presentations

Autor: T. Miller, J. Skucas, D. Gudex, C. Listinsky, J. R. Hooyman, R. L. MacCarty, H. A. Carpenter, K. W. Schroeder, H. C. Carlson, H. I. Goldberg, X. Y. Ni, S. N. Glick, S. K. Teplick, P. Feczko, R. D. Halpert, R. A. Frost, D. Lamping, S. Somers, G. Stevenson, D. J. Ott, Y. M. Chen, D. W. Gelfand, W. C. Wu, H. A. Munitz, M. L. Janower, F. J. Schwab, C. C. Lu, J. Murakami, T. Barloon, S. R. Ell, E. A. Franken, J. Farman, E. Balthazar, B. R. Javors, B. Bashist, M. S. Levine, J. Langer, M. Kligerman, I. Laufer, R. L. Bree, R. E. Schwab, S. E. Rubesin, B. Jones, E. L. Wolf, D. Frager, J. Frager, L. J. Brandt, L. H. Bernstein, T. C. Beneventano, F. P. Agha, A. J. Megibow, D. H. Hulnick, E. J. Balthazar, P. M. Silverman, M. E. Baker, C. Cooper, F. M. Kelvin, S. Teefey, D. Stephens, E. James, W. Charboneau, P. Sheedy, W. Dodds, T. Lawson, R. Darweesh, E. Stewart, D. D. Stark, J. Wittenberg, J. T. Ferrucci, D. M. Williams, K. J. Cho, A. M. Aisen, W. Martel, C. D. Johnson, W. M. Thompson, R. Herfkens, J. Utz, K. J. Wolf, B. Hamm, T. Roemer, R. Felix, H. -J. Weinmann, S. Saini, R. Kane, G. Onik, G. Steele, U. Khettry, B. Cady, W. McDermott, R. Jenkins, M. Clouse, J. Katz, J. Gilbert, B. Rubinsky, M. Ohto, N. Sugiura, M. Ebara, K. Kimura, P. J. Weyman, E. Sonnenberg, G. R. Wittich, G. Casola, A. F. Hofmann, S. A. Wilson, V. W. Wing, P. H. Haskin, J. Sammon, A. H. Dachman, J. B. Nichols, D. H. Patrick, J. E. Lichtenstein, L. G. Hanelin, M. E. Lee, P. J. Feczko, R. Halpert, D. Kastan, L. Ackerman, J. Clark, J. M. Messmer, J. J. Bradley, S. R. Cho, M. A. Turner, M. A. Mauro, T. M. Swantkowski, E. V. Staab, E. M. Bozymski, W. Shea, D. Hohn, B. Demas, R. Kerlan, T. H. Reiman, D. M. Balfe, M. J. Ormson, J. W. Charboneau, D. H. Stephens, R. K. Zeman, L. R. Clark, P. L. Choyke, M. H. Jaffe, E. G. Grant, H. Ziessman, S. B. Benjamin

Publikováno v: Gastrointestinal Radiology. 11:291-299

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e961bee6d040139033bd09c6059e956
https://doi.org/10.1007/bf02035094

Prevention of experimental allergic encephalomyelitis by ganglioside GM4. A follow-up study

Autor: B R, Mullin, D H, Patrick, C M, Poore, B H, Rupp, M T, Smith

Publikováno v: Journal of the neurological sciences. 73(1)

The myelin-specific ganglioside GM4, when incubated with myelin basic protein prior to inoculation, prevents experimental allergic encephalomyelitis in the guinea pig. The monosialoganglioside GM1, the predominant ganglioside of mammalian myelin, als

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5871238465b760b8c0ea858ceda25f1a
https://pubmed.ncbi.nlm.nih.gov/3701369

Weight-of-Biological Evidence Approach for Assessing Carcinogenicity

Autor: J. D. Burek, D. H. Patrick, R. J. Gerson

Publikováno v: Carcinogenicity ISBN: 9783642648106

Cancer is a complex, multistage, multimechanism phenomenon. Despite this, long-term rodent carcinogenicity studies have been the principal means used to assess the potential carcinogenic effect of compounds. Unfortunately, decades of carcinogenicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab4e4919d1f9753ebd1f6b984e19bf79
https://doi.org/10.1007/978-3-642-61364-7_11

Acute and subacute demyelination induced by mouse hepatitis virus strain A59 in C3H mice

Autor: J L, Woyciechowska, B D, Trapp, D H, Patrick, I C, Shekarchi, P O, Leinikki, J L, Sever, K V, Holmes

Publikováno v: Journal of experimental pathology. 1(4)

Mouse hepatitis virus (MHV, strain A-59), a coronavirus, induced acute and subacute demyelinating disease in the central nervous system of weanling C3H mice that were reported to be genetically resistant to MHV. Subtle clinical signs developed in gre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1592d836696507b9e40b0ebc43dcf1fe
https://pubmed.ncbi.nlm.nih.gov/6100984