Výsledky vyhledávání - "D H, Margulies"

Polymorphism at position nine of the MHC class I heavy chain affects the stability of association with beta 2-microglobulin and presentation of a viral peptide

Autor: R K Ribaudo, D H Margulies

Publikováno v: The Journal of Immunology. 155:3481-3493

To identify residues that control the interactions between MHC-heavy chains and (beta 2m) sequence comparisons were made between murine class I MHC molecules with high (H-2Dd, H-2Kb) and low (H-2Ld, H-2Db) affinities for beta 2m. A single residue at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::458b5ec29b4cd5b765027efec0a01335
https://doi.org/10.4049/jimmunol.155.7.3481

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Molecular analysis of the same HIV peptide functionally binding to both a class I and a class II MHC molecule

Autor: T Takeshita, H Takahashi, S Kozlowski, J D Ahlers, C D Pendleton, R L Moore, Y Nakagawa, K Yokomuro, B S Fox, D H Margulies

Publikováno v: The Journal of Immunology. 154:1973-1986

Although several peptides have been found to bind to both class I and class II molecules, the basis for this binding of the same peptide to two classes of MHC molecules has not been compared previously. We have analyzed one such peptide, P18 from the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e5926c9669d9a7048668fb67b927d0b
https://doi.org/10.4049/jimmunol.154.4.1973

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Independent and synergistic effects of disulfide bond formation, beta 2-microglobulin, and peptides on class I MHC folding and assembly in an in vitro translation system

Autor: R K Ribaudo, D H Margulies

Publikováno v: The Journal of Immunology. 149:2935-2944

We have examined the post-translational processing, intrachain disulfide bond formation, folding, and assembly of MHC class I H chains with beta 2-microglobulin after coupled in vitro translation of homogeneous mRNA and transport of nascent chains in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7dbf64eed935e212d71cb446fd5a57dd
https://doi.org/10.4049/jimmunol.149.9.2935

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Activating CTL precursors to reveal CTL function without skewing the repertoire by in vitro expansion

Autor: I M, Belyakov, J, Wang, R, Koka, J D, Ahlers, J T, Snyder, R, Tse, J, Cox, J S, Gibbs, D H, Margulies, J A, Berzofsky

Publikováno v: European journal of immunology. 31(12)

Detection of the functional CD8(+) CTL response usually requires in vitro restimulation. The differences between the CD8(+) CTL repertoire in freshly isolated precursor cells and CD8(+) CTL after short-term in vitro expansion have been generally assu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a670952eb2d3a53a9b8c6949dbc3860
https://pubmed.ncbi.nlm.nih.gov/11745375

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Structural basis of MHC class I recognition by natural killer cell receptors

Autor: M W, Sawicki, N, Dimasi, K, Natarajan, J, Wang, D H, Margulies, R A, Mariuzza

Publikováno v: Immunological reviews. 181

Natural killer (NK)-cell function is regulated by NK receptors that recognize MHC class I (MHC-I) molecules on target cells. Two structurally distinct families of NK receptors have been identified, the immunoglobulin-like family (killer cell immunogl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9aa123a7f2396fe730bd70cb180fa56b
https://pubmed.ncbi.nlm.nih.gov/11513152

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Control of autoimmunity by regulatory T cells

Autor: E M, Shevach, R S, McHugh, A M, Thornton, C, Piccirillo, K, Natarajan, D H, Margulies

Publikováno v: Advances in experimental medicine and biology. 490

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5648d6baf00a0b1bb13579308137449e
https://pubmed.ncbi.nlm.nih.gov/11505971

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A T cell receptor transgenic model of severe, spontaneous organ-specific autoimmunity

Autor: R S, McHugh, E M, Shevach, D H, Margulies, K, Natarajan

Publikováno v: European journal of immunology. 31(7)

The development of mouse models of human organ-specific autoimmune diseases has been hampered by the need to immunize mice with autoantigens in potent adjuvants. Even autoantigen-specific T cell receptor transgenic models of autoimmunity have proven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ec7e162142c359638f852911ebf235cd
https://pubmed.ncbi.nlm.nih.gov/11449363

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MHC class I molecules, structure and function

Autor: K, Natarajan, H, Li, R A, Mariuzza, D H, Margulies

Publikováno v: Reviews in immunogenetics. 1(1)

MHC class I molecules (MHC-I) are cell surface recognition elements expressed on virtually all somatic cells. These molecules sample peptides generated within the cell and signal the cell's physiological state to effector cells of the immune system,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::645ca260e6ebfe489a4204f0db43d229
https://pubmed.ncbi.nlm.nih.gov/11256571

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NK and CTL recognition of a single chain H-2Dd molecule: distinct sites of H-2Dd interact with NK and TCR

Autor: D H, Chung, J, Dorfman, D, Plaksin, K, Natarajan, I M, Belyakov, R, Hunziker, J A, Berzofsky, W M, Yokoyama, M G, Mage, D H, Margulies

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(7)

We generated transgenic mice expressing a single-chain beta2-microglobulin (beta2m)-H-2Dd. The cell-surface beta2m-H-2Dd molecule was expressed on a beta2m-deficient background and reacted with appropriate mAbs. It was of the expected m.w. and direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5bb8679c4bb41d5d28358a626b6a39d3
https://pubmed.ncbi.nlm.nih.gov/10490965

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