Zobrazeno 1 - 10
of 111
pro vyhledávání: '"D H, MacLennan"'
Publikováno v:
Europe PubMed Central
Pressure overload (PO)-induced cardiac hypertrophy in rabbits has been utilized extensively to study alterations in systolic and diastolic functions of the heart. In earlier studies we showed that the levels of mRNA encoding two important sarcoplasmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290b4596d45f21ba328bda02ecaf81b6
https://doi.org/10.1152/ajpcell.1995.268.1.c252
https://doi.org/10.1152/ajpcell.1995.268.1.c252
Autor:
D H, MacLennan, M S, Phillips
Publikováno v:
Science. 256:789-794
In humans genetically predisposed to malignant hyperthermia, anesthesia can induce skeletal muscle rigidity, hypermetabolism, and high fever, which, if not immediately reversed, can lead to tissue damage or death. The corresponding condition in swine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41625d614cc58813150657b63796ca7
https://doi.org/10.1126/science.1589759
https://doi.org/10.1126/science.1589759
Publikováno v:
Journal of Biological Chemistry. 267:2767-2774
Site-specific mutagenesis was used to replace Gly310, Gly770, and Gly801, located in the transmembrane domain of the sarcoplasmic reticulum Ca(2+)-ATPase, with either alanine or valine. In addition, Gly310 was substituted with proline. In the Gly310-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53e3fabf0cf5d839d9db5047f92dc377
https://doi.org/10.1016/s0021-9258(18)45945-5
https://doi.org/10.1016/s0021-9258(18)45945-5
Publikováno v:
Journal of Biological Chemistry. 266:18839-18845
Site-specific mutagenesis was used to investigate the functional roles of amino acids in the relatively hydrophobic sequence Ile-Thr-Thr-Cys-Leu-Ala-320, located at the M4S4 boundary of the sarcomplasmic reticulum Ca(2+)-ATPase. Each of the residues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ad6c5f173046c0f0b73674db311bf3f
https://doi.org/10.1016/s0021-9258(18)55140-1
https://doi.org/10.1016/s0021-9258(18)55140-1
Publikováno v:
Journal of Biological Chemistry. 266:16157-16164
Site-specific mutagenesis of the sarcoplasmic reticulum Ca(2+)-ATPase was used to investigate the functional roles of 18 amino acid residues located at or near the "hinge-domain," a highly conserved region of the cation-transporting ATPases. Mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14b706d90df2eae2891f98b4430826e6
https://doi.org/10.1016/s0021-9258(18)98529-7
https://doi.org/10.1016/s0021-9258(18)98529-7
Publikováno v:
Circulation Research. 69:266-276
The purpose of this study was to determine the expression of genes encoding various sarcoplasmic reticulum components that are functionally coupled with calcium release, uptake, and storage function during cardiac hypertrophy induced by thyroid hormo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018b6dfb061dced9e3381f62e20300b2
https://doi.org/10.1161/01.res.69.2.266
https://doi.org/10.1161/01.res.69.2.266
Publikováno v:
Europe PubMed Central
We have isolated three overlapping genomic clones extending over 39 kilobases (kb), which encodes the rabbit cardiac sarco(endo)plasmic reticulum Ca2(+)-ATPase gene (SERCA2). S1 nuclease mapping and primer extension analysis of the 5' end of the card
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2683db436ba1a50a204928fc9236a975
https://doi.org/10.1016/s0021-9258(19)39615-2
https://doi.org/10.1016/s0021-9258(19)39615-2
Autor:
D H, MacLennan
Publikováno v:
European journal of biochemistry. 267(17)
Transient elevations of intracellular Ca2+ play a signalling role in such complex cellular functions as contraction, secretion, fertilization, proliferation, metabolism, heartbeat and memory. However, prolonged elevation of Ca2+ above about 10 microM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2a73e479fa9347210b78cedc70d26542
https://pubmed.ncbi.nlm.nih.gov/10951187
https://pubmed.ncbi.nlm.nih.gov/10951187
Publikováno v:
The Journal of biological chemistry. 274(46)
In an earlier study (Kimura, Y., Kurzydlowski, K., Tada, M., and MacLennan, D. H. (1997) J. Biol. Chem. 272, 15061-15064), mutation of amino acids on one face of the phospholamban (PLN) transmembrane helix led to loss of PLN inhibition of sarco(endo)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0091e138df6e69c19e4563d955cbc0b
https://pubmed.ncbi.nlm.nih.gov/10551848
https://pubmed.ncbi.nlm.nih.gov/10551848
Publikováno v:
The Biochemical journal.
Because HEK-293 cells are widely used for the functional expression of channels, exchangers and transporters involved in Ca(2+) homoeostasis, the properties of intracellular Ca(2+) stores and the methods used for measuring intracellular Ca(2+) releas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b20270c9113c2c185bc90598476587c8
https://pubmed.ncbi.nlm.nih.gov/10493909
https://pubmed.ncbi.nlm.nih.gov/10493909