Zobrazeno 1 - 10
of 110
pro vyhledávání: '"D Gray, Heppner"'
Autor:
Shixia Wang, Chang Yi Wang, Hui-Kai Kuo, Wen-Jiun Peng, Juin-Hua Huang, Be-Shen Kuo, Feng Lin, Yaw-Jen Liu, Zhi Liu, Huang-Ting Wu, Shuang Ding, Kou-Liang Hou, Jennifer Cheng, Ya-Ting Yang, Ming-Han Jiang, Min-Sheng Wang, Tony Chen, Wei Guo Xia, Ed Lin, Chung Ho Hung, Hui-Jung Chen, Zhonghao Shih, Yi Ling Lin, Valorie Ryan, Mei Mei Hu, D. Gray Heppner, Delphine C. Malherbe, Sivakumar Periasamy, Natalia Kuzmina, Chandru Subramani, Michael Hellerstein, Thomas P. Monath, Alexander Rumyantsev, Alexander Bukreyev, Farshad Guirakhoo
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 2724-2734 (2022)
The development of safe and effective vaccines to respond to COVID-19 pandemic/endemic remains a priority. We developed a novel subunit protein-peptide COVID-19 vaccine candidate (UB-612) composed of: (i) receptor binding domain of SARS-CoV-2 spike p
Externí odkaz:
https://doaj.org/article/d9e5af23b5ef47048009e734003b47bf
Autor:
Chang Yi Wang, Kao-Pin Hwang, Hui-Kai Kuo, Wen-Jiun Peng, Yea-Huei Shen, Be-Sheng Kuo, Juin-Hua Huang, Hope Liu, Yu-Hsin Ho, Feng Lin, Shuang Ding, Zhi Liu, Huan-Ting Wu, Ching-Tai Huang, Yuarn-Jang Lee, Ming-Che Liu, Yi-Ching Yang, Po-Liang Lu, Hung-Chin Tsai, Chen-Hsiang Lee, Zhi-Yuan Shi, Chun-Eng Liu, Chun-Hsing Liao, Feng-Yee Chang, Hsiang-Cheng Chen, Fu-Der Wang, Kuo-Liang Hou, Jennifer Cheng, Min-Sheng Wang, Ya-Ting Yang, Han-Chen Chiu, Ming-Han Jiang, Hao-Yu Shih, Hsuan-Yu Shen, Po-Yen Chang, Yu-Rou Lan, Chi-Tian Chen, Yi-Ling Lin, Jian-Jong Liang, Chun-Che Liao, Yu-Chi Chou, Mary Kate Morris, Carl V. Hanson, Farshad Guirakhoo, Michael Hellerstein, Hui-Jing Yu, Chwan-Chuen King, Tracy Kemp, D. Gray Heppner, Thomas P. Monath
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Background The Delta and Omicron variants of SARS-CoV-2 are currently responsible for breakthrough infections due to waning immunity. We report phase I/II trial results of UB-612, a multitope subunit vaccine containing S1-RBD-sFc protein and rational
Externí odkaz:
https://doaj.org/article/6d6f293c98474b5f96a331e81908a684
Autor:
Thomas P. Monath, Patricia E. Fast, Kayvon Modjarrad, David K. Clarke, Brian K. Martin, Joan Fusco, Richard Nichols, D. Gray Heppner, Jakub K. Simon, Sheri Dubey, Sean P. Troth, Jayanthi Wolf, Vidisha Singh, Beth-Ann Coller, James S. Robertson
Publikováno v:
Vaccine: X, Vol 1, Iss , Pp - (2019)
The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) was formed to evaluate the safety and characteristics of live, recombinant viral vector vaccines. A recent publication by the V3SWG described live, attenuated, recombinant
Externí odkaz:
https://doaj.org/article/b07b8cb0eee148b0870ad44a4db1f958
Autor:
Matthew B Laurens, Bourema Kouriba, Elke Bergmann-Leitner, Evelina Angov, Drissa Coulibaly, Issa Diarra, Modibo Daou, Amadou Niangaly, William C Blackwelder, Yukun Wu, Joe Cohen, W Ripley Ballou, Johan Vekemans, David E Lanar, Sheetij Dutta, Carter Diggs, Lorraine Soisson, D Gray Heppner, Ogobara K Doumbo, Christopher V Plowe, Mahamadou A Thera
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173294 (2017)
The blood-stage malaria vaccine FMP2.1/AS02A, comprised of recombinant Plasmodium falciparum apical membrane antigen 1 (AMA1) and the adjuvant system AS02A, had strain-specific efficacy against clinical malaria caused by P. falciparum with the vaccin
Externí odkaz:
https://doaj.org/article/6d13068d77704a0982ced7606e6c4c8b
Autor:
Cummings, James F., Spring, Michele D., Schwenk, Robert J., Ockenhouse, Christian F., Kester, Kent E., Polhemus, Mark E., Walsh, Douglas S., Yoon, In-Kyu, Prosperi, Christine, Juompan, Laure Y., Lanar, David E., Krzych, Urszula, Hall, B. Ted, Ware, Lisa A., Stewart, V. Ann, Williams, Jack, Dowler, Megan, Nielsen, Robin K., Hillier, Collette J., Giersing, Birgitte K., Dubovsky, Filip, Malkin, Elissa, Tucker, Kathryn, Dubois, Marie-Claude, Cohen, Joe D., Ballou, W. Ripley, Jr, D. Gray Heppner
Publikováno v:
In Vaccine 2010 28(31):5135-5144
Autor:
Angela K Talley, Sara A Healy, Olivia C Finney, Sean C Murphy, James Kublin, Carola J Salas, Susan Lundebjerg, Peter Gilbert, Wesley C Van Voorhis, John Whisler, Ruobing Wang, Chris F Ockenhouse, D Gray Heppner, Stefan H Kappe, Patrick E Duffy
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e109654 (2014)
Controlled human malaria infection (CHMI) studies which recapitulate mosquito-borne infection are a critical tool to identify protective vaccine and drug candidates for advancement to field trials. In partnership with the Walter Reed Army Institute o
Externí odkaz:
https://doaj.org/article/9dec0d2f30984aa399c44cbf017dbfe2
Autor:
Matthew B Laurens, Mahamadou A Thera, Drissa Coulibaly, Amed Ouattara, Abdoulaye K Kone, Ando B Guindo, Karim Traore, Idrissa Traore, Bourema Kouriba, Dapa A Diallo, Issa Diarra, Modibo Daou, Amagana Dolo, Youssouf Tolo, Mahamadou S Sissoko, Amadou Niangaly, Mady Sissoko, Shannon Takala-Harrison, Kirsten E Lyke, Yukun Wu, William C Blackwelder, Olivier Godeaux, Johan Vekemans, Marie-Claude Dubois, W Ripley Ballou, Joe Cohen, Tina Dube, Lorraine Soisson, Carter L Diggs, Brent House, Jason W Bennett, David E Lanar, Sheetij Dutta, D Gray Heppner, Christopher V Plowe, Ogobara K Doumbo
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79323 (2013)
The FMP2.1/AS02A candidate malaria vaccine was tested in a Phase 2 study in Mali. Based on results from the first eight months of follow-up, the vaccine appeared well-tolerated and immunogenic. It had no significant efficacy based on the primary endp
Externí odkaz:
https://doaj.org/article/f3e7f0ed2aed4ebb916e5715672cdd1e
Autor:
Joanne M Lumsden, Robert J Schwenk, Lisa E Rein, Philippe Moris, Michel Janssens, Opokua Ofori-Anyinam, Joe Cohen, Kent E Kester, D Gray Heppner, Urszula Krzych
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e20775 (2011)
A phase 2a RTS,S/AS malaria vaccine trial, conducted previously at the Walter Reed Army Institute of Research, conferred sterile immunity against a primary challenge with infectious sporozoites in 40% of the 80 subjects enrolled in the study. The fre
Externí odkaz:
https://doaj.org/article/15d32dd5c3414b5f9155b9d7893030d0
Autor:
Mahamadou A Thera, Ogobara K Doumbo, Drissa Coulibaly, Matthew B Laurens, Abdoulaye K Kone, Ando B Guindo, Karim Traore, Mady Sissoko, Dapa A Diallo, Issa Diarra, Bourema Kouriba, Modibo Daou, Amagana Dolo, Mounirou Baby, Mahamadou S Sissoko, Issaka Sagara, Amadou Niangaly, Idrissa Traore, Ally Olotu, Olivier Godeaux, Amanda Leach, Marie-Claude Dubois, W Ripley Ballou, Joe Cohen, Darby Thompson, Tina Dube, Lorraine Soisson, Carter L Diggs, Shannon L Takala, Kirsten E Lyke, Brent House, David E Lanar, Sheetij Dutta, D Gray Heppner, Christopher V Plowe
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9041 (2010)
The objective was to evaluate the safety and immunogenicity of the AMA1-based malaria vaccine FMP2.1/AS02(A) in children exposed to seasonal falciparum malaria.A Phase 1 double blind randomized controlled dose escalation trial was conducted in Bandia
Externí odkaz:
https://doaj.org/article/cc6d77a455c44be3828ff996e6e1400d
Autor:
Sheetij Dutta, JoAnn S Sullivan, Katharine K Grady, J David Haynes, Jack Komisar, Adrian H Batchelor, Lorraine Soisson, Carter L Diggs, D Gray Heppner, David E Lanar, William E Collins, John W Barnwell
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8138 (2009)
A Plasmodium falciparum 3D7 strain Apical Membrane Antigen-1 (AMA1) vaccine, formulated with AS02(A) adjuvant, slowed parasite growth in a recent Phase 1/2a trial, however sterile protection was not observed. We tested this AS02(A), and a Montanide I
Externí odkaz:
https://doaj.org/article/bb5f1754422943d2bdcfca2852651770