Regulation of Cell Survival During B Lymphopoiesis: Apoptosis and Bcl-2/Bax Content of Precursor B Cells in Bone Marrow of Mice with Altered Expression of IL-7 and Recombinase-Activating Gene-2

Autor: L, Lu, P, Chaudhury, D G, Osmond

Publikováno v: The Journal of Immunology. 162:1931-1940

B cell development in mouse bone marrow depends critically upon IL-7. To examine the possible in vivo trophic role of IL-7, we have quantitated apoptosis and Bcl-2 family proteins in populations of phenotypically defined B lineage cells in IL-7-defic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc1154d8b050bf2253ceb3c2c5722f2
https://doi.org/10.4049/jimmunol.162.4.1931

Perturbation of B cell genesis in the bone marrow of pristane-treated mice. Implications for plasmacytoma induction

Autor: S A Rico-Vargas, M Potter, D G Osmond

Publikováno v: The Journal of Immunology. 154:2082-2091

A single injection of pristane was given i.p. to plasmacytoma-susceptible BALB/cAn mice. At intervals up to 6 mo thereafter, immunofluorescence labeling of intranuclear terminal deoxynucleotidyl transferase (TdT), cell surface B220 glycoprotein, cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35553400b1cbc15b1099968e564a9dfb
https://doi.org/10.4049/jimmunol.154.5.2082

Regulation and Localization of Lymphocyte Production in the Bone Marrow

Autor: M. T. E. Fahlman, D. G. Osmond, G. M. Fulop, D. M. Rahal

Publikováno v: Novartis Foundation Symposia ISBN: 9780470720660
Ciba Foundation Symposium 84-Microenvironments in Haemopoietic and Lymphoid Differentiation

The homeostatic mechanisms which control B lymphocyte renewal in the bone marrow are unknown. Mouse bone marrow produces many small lymphocytes which develop surface IgM and other B lymphocyte properties. Putative precursors show cytoplasmic mu chain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b723b4367461abcdc0f285e8556b45c8
https://doi.org/10.1002/9780470720660.ch5

Regulation of cell survival during B lymphopoiesis in mouse bone marrow: enhanced pre-B-cell apoptosis in CSF-1-deficient op/op mutant mice

Autor: L, Lu, D G, Osmond

Publikováno v: Experimental hematology. 29(5)

Osteopetrotic (op/op) mice are deficient in macrophages and osteoclasts due to a CSF-1 gene mutation. The aim of this study was to evaluate the effect of these deficiencies and of CSF-1-dependent mechanisms on B lymphopoiesis in bone marrow, with spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e05fb1e4ead28985703e7dac323f785c
https://pubmed.ncbi.nlm.nih.gov/11376872

Melatonin inhibits apoptosis during early B-cell development in mouse bone marrow

Autor: Q, Yu, S C, Miller, D G, Osmond

Publikováno v: Journal of pineal research. 29(2)

The pineal secretory product, melatonin, exerts a variety of effects on the immune system. Administration of melatonin stimulates cell-mediated immunity, particularly by inhibiting apoptosis among T lymphocytes in the thymus and inducing production o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::29e58b4a8f90b63703a239f45f8cdde9
https://pubmed.ncbi.nlm.nih.gov/10981821