Výsledky vyhledávání - "D G Gilliland"

Program and Abstracts

Autor: Charles P. Lin, D. G. Gilliland, David T. Scadden, David A. Williams, Francesca Ferraro, Stephen M. Sykes, Steven W. Lane, C. Lo Celso

Publikováno v: Experimental Hematology. 38:S1-S136

Hematopoietic stem cells (HSC) require complex bidirectional signals from the hematopoietic microenvironment (HM) and there is emerging evidence that leukemia stem cells (LSC) reside in similar niches within the HM. Existing models of LSC-niche inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f19213a7873d09ba10fa01dfb495300f
https://doi.org/10.1016/j.exphem.2010.07.008

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Accurate Detection of Uniparental Disomy and Microdeletions by SNP Array Analysis in Myelodysplastic Syndromes with Normal Cytogenetics

Autor: Ross L. Levine, R. V. Kulkarni, Mignon L. Loh, E. Estey, A T Look, Hagop M. Kantarjian, Stefan Heinrichs, Cheng Li, C. E. Bueso-Ramos, Steven M. Kornblau, J.-P. Issa, Guillermo Garcia-Manero, D. G. Gilliland, Donna Neuberg

Publikováno v: Leukemia
Leukemia, vol 23, iss 9

Progress in the management of patients with myelodysplastic syndromes (MDS) has been hampered by the inability to detect cytogenetic abnormalities in 40-60% of cases. We prospectively analyzed matched pairs of bone marrow and buccal cell (normal) DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e419b26a409ce25d62cac61a93c0dd6a
http://europepmc.org/articles/PMC2950785

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Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates

Autor: Ross L. Levine, Terra L. Lasho, Ken-Hong Lim, Christy Finke, Jawaharlal M. Patel, Chin-Yang Li, Animesh Pardanani, Omar Abdel-Wahab, D. G. Gilliland, Ann Mullally, A Tefferi

Publikováno v: Leukemia. 23:900-904

TET2 (TET oncogene family member 2) is a candidate tumor suppressor gene located at chromosome 4q24, and was recently reported to be mutated in ~14% of patients with JAK2 V617F-positive myeloproliferative neoplasms. We used high-throughput DNA sequen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7143ab9169b6777d09fefb15dc175e48
https://doi.org/10.1038/leu.2009.37

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Extending Jak2V617F and MplW515 Mutation Analysis to Single Hematopoietic Colonies and B and T Lymphocytes

Autor: D. G. Gilliland, Ayalew Tefferi, William J. Hogan, Terra L. Lasho, Christy Finke, Rhett P. Ketterling, Animesh Pardanani, Ruben A. Mesa

Publikováno v: Stem Cells. 25:2358-2362

JAK2V617F and MPLW515L/K are myeloproliferative disorder (MPD)-associated mutations. We genotyped 552 individual hematopoietic colonies obtained by CD34+ cell culture from 16 affected patients (13 JAK2V617F and 3 MPLW515L/K) to determine (a) the prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94c9a0d2b1342797faa872ee5617f69
https://doi.org/10.1634/stemcells.2007-0175

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Concomitant neutrophil JAK2V617F mutation screening and PRV-1 expression analysis in myeloproliferative disorders and secondary polycythaemia

Autor: Ruben A. Mesa, David P. Steensma, Alexandra P. Wolanskyj, Ayalew Tefferi, D. G. Gilliland, Susan M. Schwager, Shireen Sirhan, David Dingli, Terra L. Lasho, Chin Yang Li

Publikováno v: British Journal of Haematology. 131:166-171

Polycythaemia vera (PV) is closely associated with both an acquired activating mutation of the JAK2 tyrosine kinase (JAK2(V617F)) in granulocyte-derived DNA and increased granulocyte polycythaemia rubra vera-1 (PRV-1) expression. In order to explore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8b7427ee34ed340fb0bf1b7f49fa8fc
https://doi.org/10.1111/j.1365-2141.2005.05743.x

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FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies

Autor: Nicole Duclos, Jeffery L. Kutok, Constantine S. Mitsiades, Allison Coburn, Jennifer Adelsperger, D. G. Gilliland, Rachel Okabe, Brian J. P. Huntly, James D. Griffin, Ifor R. Williams, Benjamin H. Lee, Sandra A. Moore, Jing Chen, Kenneth C. Anderson, Sarah Cohen, Doriano Fabbro

Publikováno v: Oncogene. 24:8259-8267

Reccurent chromosomal translocation t(4;14) (p16.3;q32.3) occurs in patients with multiple myeloma (MM) and is associated with ectopic overexpression of fibroblast growth factor receptor 3 (FGFR3) that sometimes may contain the activation mutations s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce29b28e6dba9353d6ac4d4b192ca71
https://doi.org/10.1038/sj.onc.1208989

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Clinical and molecular features of FIP1L1-PDFGRA (+) chronic eosinophilic leukemias

Autor: Gregor Verhoef, A. Van Hoof, Iwona Wlodarska, Anne Hagemeijer, Florence Roufosse, Lucienne Michaux, M-C Herregods, Peter Marynen, Marie Maerevoet, Pierre Zachee, Peter Vandenberghe, D. G. Gilliland, Dominik Selleslag, Jan Cools, D Vanstraelen, Marc Boogaerts

Publikováno v: Leukemia. 18:734-742

Detection of the FIP1L1-PDGFRA fusion gene or the corresponding cryptic 4q12 deletion supports the diagnosis of chronic eosinophilic leukemia (CEL) in patients with chronic hypereosinophilia. We retrospectively characterized 17 patients fulfilling WH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be8335fd700e4cc95d9aba99edd0cb1
https://doi.org/10.1038/sj.leu.2403313

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Role of FLT3 in leukemia

Autor: D. G. Gilliland, James D. Griffin

Publikováno v: Current Opinion in Hematology. 9:274-281

FLT3 is the most frequently mutated gene in cases of acute myelogenous leukemia (AML). About 30 to 35% of patients have either internal tandem duplications (ITDs) in the juxtamembrane domain or mutations in the activating loop of FLT3. FLT3 mutations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d14fadabe944be2e9b4cd98b27e47e5b
https://doi.org/10.1097/00062752-200207000-00003

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Cooperativity between mutations in tyrosine kinases and in hematopoietic transcription factors in AML

Autor: D. G. Gilliland, K Deguchi

Publikováno v: Leukemia. 16:740-744

Cooperativity between mutations in tyrosine kinases and in hematopoietic transcription factors in AML

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::272a65a03b6370c2d0e9df5af4598298
https://doi.org/10.1038/sj.leu.2402500

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