Zobrazeno 1 - 10
of 22
pro vyhledávání: '"D G, Wilkins"'
Publikováno v:
Forensic science review. 9(2)
Forensic urine drug-testing laboratories operate in a prescribed scientific and administrative manner to ensure accurate test results. All specimens positive by an initial immunoassay test must be confirmed by gas chromatography/mass spectrometry (GC
Publikováno v:
Anaesthesia. 48:396-401
Seven infusion nomograms are presented for the rapid and accurate composition of continuous infusions. The construction of these nomograms is described.
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 295(3)
Single and multiple high-dose administrations of methamphetamine (METH) differentially decrease dopamine (DA) transporter (DAT) function, as assessed by measuring [(3)H]DA uptake into rat striatal synaptosomes prepared 1 h after treatment. Prevention
Publikováno v:
Journal of analytical toxicology. 21(6)
A sensitive and specific method was developed for the quantitative analysis of l-alpha-acetylmethadol (LAAM), l-alpha-acetyl-N-normethadol (norLAAM), and l-alpha-acetyl-N,N-dinormethadol (dinorLAAM) in hair. In the development of this method, it was
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 283(1)
Administration of a single high dose of methamphetamine (METH) causes a rapid and reversible decrease in the activity of the tryptophan hydroxylase (TPH), the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine. This effect can be reversed c
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 282(2)
Reactive oxygen species decrease dopamine transporter (DAT) function in vitro. Because of this, and the finding that METH administration causes oxygen radical formation in vivo, the effects of METH administration on DAT activity in rat striatum were
Publikováno v:
Journal of mass spectrometry : JMS. 31(9)
A sensitive and specific method was developed for the determination of alprazolam and its major metabolite alpha-hydroxyalprazolam in plasma. After the addition of deuterium-labeled internal standards, plasma samples were buffered to pH 9 with 1 ml o
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(4)
Xenobiotics circulating in the blood may become incorporated into growing hair. Melanin has affinity for many pharmacologically unrelated drugs and is responsible for the pigmentation in hair. To assess the role of pigmentation in the incorporation o
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(3)
Drugs and endogenous compounds may be incorporated into the matrix of a growing hair shaft. However, the relationship between incorporation and dose or time course of plasma concentrations is poorly defined. The purpose of this study was to compare p
Publikováno v:
Anaesthesia. 48(6)
In a randomised, double-blind study, the effect of addition of 1 mg of diamorphine to 4 ml of 0.5% bupivacaine for spinal anaesthesia was studied in two groups each of 30 patients presenting for either transurethral genito-urinary surgery, or for low