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Mechanism of inhibition of cathepsin K by potent, selective 1, 5-diacylcarbohydrazides: a new class of mechanism-based inhibitors of thiol proteases

Autor: M J, Bossard, T A, Tomaszek, M A, Levy, C F, Ijames, M J, Huddleston, J, Briand, S, Thompson, S, Halpert, D F, Veber, S A, Carr, T D, Meek, D G, Tew

Publikováno v: Biochemistry. 38(48)

The nature of the inhibition of thiol proteases by a new class of mechanism-based inhibitors, 1,5-diacylcarbohydrazides, is described. These potent, time-dependent, active-site spanning inhibitors include compounds that are selective for cathepsin K,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a6f7ece91586583a3481bd2f32db939
https://pubmed.ncbi.nlm.nih.gov/10625455

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Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor

Autor: C H, MacPhee, K E, Moores, H F, Boyd, D, Dhanak, R J, Ife, C A, Leach, D S, Leake, K J, Milliner, R A, Patterson, K E, Suckling, D G, Tew, D M, Hickey

Publikováno v: The Biochemical journal. 338

A novel and potent azetidinone inhibitor of the lipoprotein-associated phospholipase A2 (Lp-PLA2), i.e. platelet-activating factor acetylhydrolase, is described for the first time. This inhibitor, SB-222657 (Ki=40+/-3 nM, kobs/[I]=6. 6x10(5) M-1.s-1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::626460f359a74e1b15f305f443280f4d
https://pubmed.ncbi.nlm.nih.gov/10024526

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Dissection of NADPH-cytochrome P450 oxidoreductase into distinct functional domains

Autor: C R Wolf, Gillian Smith, D. G. Tew

NADPH-cytochrome P450 oxidoreductase transfers electrons from NADPH to cytochrome P450 and catalyzes the one-electron reduction of many drugs and foreign compounds. This enzyme is a flavoprotein containing the cofactors FMN and FAD, which are essenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e27515779634ff890d8e977c2ee4423
https://europepmc.org/articles/PMC44676/

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Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase

Autor: Owen T.G. Jones, B V O'Donnell, D G Tew, P J England

Publikováno v: The Biochemical journal. 290

Diphenyleneiodonium (DPI) and its analogues have been previously shown to react via a radical mechanism whereby an electron is abstracted from a nucleophile to form a radical, which then adds back to the nucleophile to form covalent adducts [Banks (1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5396a4ea246e03bb258250b40ec7e8f
https://pubmed.ncbi.nlm.nih.gov/8439298

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Autoantibodies to hepatic microsomal carboxylesterase in halothane hepatitis

Autor: David J. Harrison, C R Wolf, Gillian Smith, D. G. Tew, J.G. Kenna

Publikováno v: The Lancet. 342:963-964

Halothane hepatitis can be life-threatening and this severe adverse reaction may arise via an immune process. We have detected autoantibodies to purified human liver microsomal carboxylesterase in sera of 17 out of 20 patients with halothane hepatiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8708e801da9bcc175ae4dd72b6827a
https://doi.org/10.1016/0140-6736(93)92005-e

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ChemInform Abstract: NITROGEN-15 NMR STUDIES OF NITROSYL (BENT AND LINEAR), NITRO, AND NITRITO LIGANDS IN 4-, 5-, AND 6-COORDINATE COMPLEXES OF THE PLATINUM METALS

Autor: Joan Mason, L. K. Bell, D. G. Tew, D. M. P. Mingos

Publikováno v: Chemischer Informationsdienst. 15

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f49e4c8958bc5554047a8e423e373ce
https://doi.org/10.1002/chin.198408046

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