Zobrazeno 1 - 10
of 14
pro vyhledávání: '"D G, Standaert"'
Autor:
A. M. Schonhoff, D. A. Figge, G. P. Williams, A. Jurkuvenaite, N. J. Gallups, G. M. Childers, J. M. Webster, D. G. Standaert, J. E. Goldman, A. S. Harms
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Dopaminergic cell loss due to the accumulation of α-syn is a core feature of the pathogenesis of Parkinson disease. Neuroinflammation specifically induced by α-synuclein has been shown to exacerbate neurodegeneration, yet the role of centr
Externí odkaz:
https://doaj.org/article/56e05103cfa346b0beeae02b46eedc2e
Publikováno v:
The Journal of comparative neurology. 421(2)
The potential role for dopamine in the subthalamic nucleus was investigated in human postmortem tissue sections by examining; (1) immunostaining for tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis; (2) binding of [(3)H]-SCH2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc4beb84d026db613ba1a3d57c395d68
https://pubmed.ncbi.nlm.nih.gov/10813785
https://pubmed.ncbi.nlm.nih.gov/10813785
Autor:
K D, Küppenbender, D G, Standaert, T J, Feuerstein, J B, Penney, A B, Young, G B, Landwehrmeyer
Publikováno v:
The Journal of comparative neurology. 419(4)
N-methyl-D-aspartate (NMDA) receptors are composed of subunits from two families: NR1 and NR2. We used a dual-label in situ hybridization technique to assess the levels of NR1 and NR2A-D messenger ribonucleic acid (mRNA) expressed in projection neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::008b0388a7fb54a0565857421fb1ad66
https://pubmed.ncbi.nlm.nih.gov/10742712
https://pubmed.ncbi.nlm.nih.gov/10742712
Publikováno v:
Molecular pharmacology. 57(2)
Recent evidence has linked striatal N-methyl-D-aspartate (NMDA) receptor function to the adverse effects of long-term dopaminergic treatment in Parkinson's disease. We have studied the abundance, composition, and phosphorylation of NMDA receptor subu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::efcf05444aded452a5b283f34ba6476b
https://pubmed.ncbi.nlm.nih.gov/10648644
https://pubmed.ncbi.nlm.nih.gov/10648644
Publikováno v:
Annals of neurology. 46(5)
To gain insight into the neural pathways involved in the pathogenesis of DYT1 dystonia, we have mapped the cellular expression of the mRNA encoding torsinA and the closely related family member, torsinB, in normal adult human brain. Here, we report a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cab867c2fcc58e030e666f52c1ccb412
https://pubmed.ncbi.nlm.nih.gov/10553994
https://pubmed.ncbi.nlm.nih.gov/10553994
Publikováno v:
The Journal of comparative neurology. 415(2)
Alternative splicing of the mRNA encoding the N-methyl-D-aspartate (NMDA) receptor subunit NR1 changes the structural, physiologic, and pharmacologic properties of the resultant NMDA receptors. We used dual label immunocytochemistry and confocal micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9389bd6c7dc2d66a8d7cb616551d2036
https://pubmed.ncbi.nlm.nih.gov/10545160
https://pubmed.ncbi.nlm.nih.gov/10545160
Autor:
C M, Kosinski, S, Risso Bradley, P J, Conn, A I, Levey, G B, Landwehrmeyer, J B, Penney, A B, Young, D G, Standaert
Publikováno v:
The Journal of comparative neurology. 415(2)
Metabotropic glutamate receptors (mGluRs) coupled to G-proteins have important roles in the regulation of basal ganglia function. We have examined the localization of the mGluR7 mRNA and mGluR7a protein in the basal ganglia of the rat. Strong mGluR7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b5a2aad1cb748f90d1373e9c8ff2ca7
https://pubmed.ncbi.nlm.nih.gov/10545164
https://pubmed.ncbi.nlm.nih.gov/10545164
Publikováno v:
The Journal of comparative neurology. 407(1)
Recent studies suggest that metabotropic glutamate receptors (mGluRs) may play a significant role in regulating basal ganglia functions. In this study, we investigated the localization of mGluR4a protein in the mouse and rat basal ganglia. Polyclonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05dfaa9e97611f7c71679b9691e84c8c
https://pubmed.ncbi.nlm.nih.gov/10213186
https://pubmed.ncbi.nlm.nih.gov/10213186
Autor:
C M, Kosinski, D G, Standaert, T J, Counihan, C R, Scherzer, J A, Kerner, L P, Daggett, G, Veliçelebi, J B, Penney, A B, Young, G B, Landwehrmeyer
Publikováno v:
The Journal of comparative neurology. 390(1)
N-methyl-D-aspartate receptors (NRs) play an important role in basal ganglia function. By using in situ hybridization with ribonucleotide probes, we investigated the regional and cellular distribution of NR subunit mRNA expression in the human basal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c951d64ae306b44ced59b7650494b05
https://pubmed.ncbi.nlm.nih.gov/9456176
https://pubmed.ncbi.nlm.nih.gov/9456176
Publikováno v:
The Journal of comparative neurology. 390(1)
Metabotropic glutamate receptors (mGluRs), which couple glutamate to second messengers, have important roles in the regulation of movement by the basal ganglia. We used two polyclonal antisera to mGluR1a and mGluR2/3 and confocal laser microscopy to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e5eca8ce307508019b145bac20f279e
https://pubmed.ncbi.nlm.nih.gov/9456172
https://pubmed.ncbi.nlm.nih.gov/9456172