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pro vyhledávání: '"D G, Pacanowska"'
Autor:
S F, Chowdhury, V B, Villamor, R H, Guerrero, I, Leal, R, Brun, S L, Croft, J M, Goodman, L, Maes, L M, Ruiz-Perez, D G, Pacanowska, I H, Gilbert
Publikováno v:
Journal of medicinal chemistry. 42(21)
This paper concerns the design, synthesis, and evaluation of inhibitors of leishmanial and trypanosomal dihydrofolate reductase. Initially study was made of the structures of the leishmanial and human enzyme active sites to see if there were signific