Zobrazeno 1 - 10
of 87
pro vyhledávání: '"D G, Hardie"'
Autor:
Fiona M. Russell, D. G. Hardie
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 186, p 186 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 186, p 186 (2021)
AMP-activated protein kinase (AMPK) is a key regulator of cellular energy balance. In response to metabolic stress, it acts to redress energy imbalance through promotion of ATP-generating catabolic processes and inhibition of ATP-consuming processes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfe1def44bd341521744145a9520c29
https://doi.org/10.3390/ijms22010186
https://doi.org/10.3390/ijms22010186
Autor:
D. G. Hardie
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 6, Iss 1, Pp 1-19 (2016)
Acta Pharmaceutica Sinica B, Vol 6, Iss 1, Pp 1-19 (2016)
The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that is almost universally expressed in eukaryotic cells. While it appears to have evolved in single-celled eukaryotes to regulate energy balance in a cell-autonomous manne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7254a8534502e65099a1cb1c056bdac
http://europepmc.org/articles/PMC4724661
http://europepmc.org/articles/PMC4724661
Autor:
D. G. Hardie
Publikováno v:
AACR Education book. 2014:67-72
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2a3fe280778040f1cbc7617e9b28867
https://doi.org/10.1158/aacr.edb-14-8097
https://doi.org/10.1158/aacr.edb-14-8097
Autor:
D G Hardie
Publikováno v:
International Journal of Obesity. 32:S7-S12
The AMP-activated protein kinase (AMPK) system is a key player in regulating energy balance at both the cellular and whole-body levels, placing it at centre stage in studies of obesity, diabetes and the metabolic syndrome. It is switched on in respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a50c77becd5a44af9fc863f0e0246a
https://doi.org/10.1038/ijo.2008.116
https://doi.org/10.1038/ijo.2008.116
Autor:
D G Hardie, Matthijs K. C. Hesselink, P M Frederik, Michaela Thomason-Hughes, B Roorda, A Abuin, Patrick Schrauwen, John C. Clapham, Kevin A. Green
Publikováno v:
International Journal of Obesity, 28(6), 824-8. Nature Publishing Group
OBJECTIVE: An unexplained phenotype of mice overexpressing human UCP3 is their improved glucose homeostasis. Since overexpression of UCP3 might affect the energy charge of the cell, we investigated whether these mice have an increased AMP-activated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f832855e6697b53178a6cf52f17cd8
https://doi.org/10.1038/sj.ijo.0802629
https://doi.org/10.1038/sj.ijo.0802629
Autor:
Eric B. Taylor, B.E. Paxton, D. G. Hardie, S. H. Park, D.S. Rubink, Lyle J. Greenwood, William W. Winder, Kirsty J. Mustard
Publikováno v:
Biochemical Society Transactions. 31:182-185
Evidence is accumulating for roles of AMP-activated protein kinase (AMPK) in controlling glucose uptake, fatty acid oxidation and gene expression in skeletal muscle. Relatively little is known, however, about the control of expression of the AMPK sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b10eb2a2c824fc4e391435703e4f2b
https://doi.org/10.1042/bst0310182
https://doi.org/10.1042/bst0310182
Publikováno v:
Journal of Applied Physiology. 93:2081-2088
AMP-activated protein kinase (AMPK) consists of three subunits: α, β, and γ. Two isoforms exist for the α-subunit (α1and α2), two for the β-subunit (β1and β2), and three for the γ-subunit (γ1, γ2, and γ3). Although the specific roles of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f615c11c8e8ea80acba442332b8f37
https://doi.org/10.1152/japplphysiol.00504.2002
https://doi.org/10.1152/japplphysiol.00504.2002
Autor:
Sheng-Cai Lin, D. G. Hardie
Publikováno v:
F1000Research
Orthologues of AMP-activated protein kinase (AMPK) occur in essentially all eukaryotes as heterotrimeric complexes comprising catalytic α subunits and regulatory β and γ subunits. The canonical role of AMPK is as an energy sensor, monitoring level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9215cb7eb15bd3a205aac521f7d25dc5
https://doi.org/10.12688/f1000research.11960.1
https://doi.org/10.12688/f1000research.11960.1
Autor:
E A, Rog-Zielinska, M-A, Craig, J R, Manning, R V, Richardson, G J, Gowans, D R, Dunbar, K, Gharbi, C J, Kenyon, M C, Holmes, D G, Hardie, G L, Smith, K E, Chapman
Publikováno v:
Cell Death and Differentiation
Glucocorticoid levels rise dramatically in late gestation to mature foetal organs in readiness for postnatal life. Immature heart function may compromise survival. Cardiomyocyte glucocorticoid receptor (GR) is required for the structural and function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b71ec597ed1c2a8a488df6ad35a72e3
https://pubmed.ncbi.nlm.nih.gov/25361084
https://pubmed.ncbi.nlm.nih.gov/25361084
Publikováno v:
Plant Molecular Biology. 45:731-741
Using a PCR approach, we have cloned DNA encoding a catalytic subunit isoform (SnRK1-α1) of SNF1-related protein kinase-1 from spinach leaf. The predicted amino acid sequence falls into the SnRK1a sub-family, and is closely related to SnRK1a sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e698ed5e0967e51c5c47c24b7a3bd39
https://doi.org/10.1023/a:1010600603276
https://doi.org/10.1023/a:1010600603276