Zobrazeno 1 - 10
of 13
pro vyhledávání: '"D G, Hafenrichter"'
Autor:
Y Z Lin, Elizabeth M. Brunt, D. G. Hafenrichter, R V Pearline, M. W. Flye, William M. Bowling, Katherine P. Ponder, Susan Kennedy, K J Shen
Publikováno v:
Hepatology. 24:838-848
An understanding of how oncogenes affect differentiated liver functions might lead to improved treatments for liver cancer or other disorders where liver-specific functions are compromised. A retroviral vector that coexpressed beta-galactosidase (bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7204dc95170a6154cb32a200d1f16d2
https://doi.org/10.1002/hep.510240415
https://doi.org/10.1002/hep.510240415
Publikováno v:
Journal of Surgical Research. 58:592-598
Although the molecular signaling mechanisms underlying macrophage endotoxin (LPS) responsiveness are not fully understood, alterations in intracellular phosphatidylinositol (PI) metabolism appear to contribute. We evaluated the effects of endotoxin t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48a54598d2c58d32396cf44dece6046
https://doi.org/10.1006/jsre.1995.1093
https://doi.org/10.1006/jsre.1995.1093
Autor:
Susan Kennedy, M. W. Flye, Xiaoyun Wu, S. D. Rettinger, D. G. Hafenrichter, Katherine P. Ponder
Publikováno v:
Blood. 84:3394-3404
Hepatic gene therapy could be used to treat a number of inherited blood diseases such as hemophilia or thrombophilia. Although liver-directed retroviral transduction can result in long-term gene expression in vivo, the low level of protein production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4842fc200c6286e14aa6364f6f9f8a56
https://doi.org/10.1182/blood.v84.10.3394.3394
https://doi.org/10.1182/blood.v84.10.3394.3394
Publikováno v:
Blood. 84:3394-3404
Hepatic gene therapy could be used to treat a number of inherited blood diseases such as hemophilia or thrombophilia. Although liver-directed retroviral transduction can result in long-term gene expression in vivo, the low level of protein production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed51e8868b7deb36ec591cdf642db358
https://doi.org/10.1182/blood.v84.10.3394.bloodjournal84103394
https://doi.org/10.1182/blood.v84.10.3394.bloodjournal84103394
Autor:
S. C. Kennedy, S. D. Rettinger, Xiaoyun Wu, Katherine P. Ponder, R. L. Saylors, M. W. Flye, D. G. Hafenrichter
Publikováno v:
Proceedings of the National Academy of Sciences. 91:1460-1464
Liver-directed gene therapy will be applicable to many inherited diseases. Although various protocols have been devised for in vivo delivery of retrovirus, comparison of hepatocyte transduction frequencies has been difficult due to variations in retr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2e50191fddd43616ed22788f326963
https://doi.org/10.1073/pnas.91.4.1460
https://doi.org/10.1073/pnas.91.4.1460
Autor:
D. G. Hafenrichter, Susan Kennedy, M. W. Flye, S. D. Rettinger, Saylors Rl, Katherine P. Ponder
Publikováno v:
Journal of Surgical Research. 54:418-425
Gene therapy research would be facilitated by a technically simple procedure for transducing hepatocytes in vivo. Previously reported methods have employed partial hepatectomy followed 24 hr later by asanguineous perfusion of the regenerating liver w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fddaf741ae339032e6616e995d4ac60
https://doi.org/10.1006/jsre.1993.1066
https://doi.org/10.1006/jsre.1993.1066
Publikováno v:
Cancer research. 55(22)
The cell of origin of hepatocellular carcinoma (HCC) is controversial. A method for marking cells of different lineages in vivo and then determining their carcinogenic potential should resolve this issue. A retroviral vector expressing activated ras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3aa19779058f1ff8b864b1ae855fb59c
https://pubmed.ncbi.nlm.nih.gov/7585583
https://pubmed.ncbi.nlm.nih.gov/7585583
Publikováno v:
Transplantation proceedings. 26(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd9238f4199100dc89d725bf6864c949
https://pubmed.ncbi.nlm.nih.gov/7998182
https://pubmed.ncbi.nlm.nih.gov/7998182
Publikováno v:
Shock (Augusta, Ga.). 2(4)
Kupffer cells (KC) of the hepatic sinusoid respond to endotoxemia by producing mediators which promote or inhibit systemic inflammatory responses. Sublethal lipopolysaccharide (LPS) pretreatment confers tolerance to the lethality of a subsequent LPS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::74637853fdcfd064c55f0065de61be44
https://pubmed.ncbi.nlm.nih.gov/7757516
https://pubmed.ncbi.nlm.nih.gov/7757516
Autor:
R. S. Saylors, Katherine P. Ponder, Susan Kennedy, Xiaoyan Wu, D. G. Hafenrichter, S. D. Rettinger, M. W. Flye
Publikováno v:
The Journal of surgical research. 56(6)
Liver-directed gene therapy could dramatically alter the therapy of many inherited hematologic and metabolic diseases. We have developed a rapid, reliable, low-mortality method for the in vivo delivery in rats of retroviral vectors 24 hr after 70% he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1e5b4359f13af74fe795f876471b43
https://pubmed.ncbi.nlm.nih.gov/8015304
https://pubmed.ncbi.nlm.nih.gov/8015304