Zobrazeno 1 - 10
of 107
pro vyhledávání: '"D G, Cooper"'
Autor:
D G, Cooper
Publikováno v:
The Indian Medical Gazette
Publikováno v:
Postgraduate Medical Journal. 85:688-692
Abdominal aortic aneurysm is a common—but preventable—cause of death in elderly men; 4% of men at the age of 65 years have an aorta >3 cm in diameter. Continued expansion runs the risk of aneurysm rupture, a condition that is fatal in all but 15%
Autor:
Rongxian Ding, Taisei Kinoshita, Tarikere L. Gururaja, Jianing Huang, Stephanie Yung, Robin D. G. Cooper, Xiulan Zhou, John R. McLaughlin, Rajinder Singh, Donald G. Payan, Esteban Masuda, Sarkiz Daniel-Issakani
Publikováno v:
Chemistry & Biology. 14:1105-1118
Small-molecule library screening to find compounds that inhibit TNFalpha-induced, but not interleukin 1beta (IL-1beta)-induced, intercellular adhesion molecule 1 (ICAM-1) expression in lung epithelial cells identified a class of triazoloquinoxalines.
Autor:
Jeffrey J. Skelton, Karine Fabio, Robin D. G. Cooper, Robert F. Bruns, Gary A. Koppel, Stephen W. Kaldor, David C. Hunden, Bruce A. Dressman, Michael P. Clay, Mitchell I. Steinberg, Michael J. Brownstein, Neal G. Simon, Christophe Guillon, Craig F. Ferris, Marvin J. Miller, Michael O. Chaney, Shi-fang Lu, Ned D. Heindel
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:2054-2080
The azetidinone LY307174 (1) was identified as a screening lead for the vasopressin V1a receptor (IC50 45 nM at the human V1a receptor) based on molecular similarity to ketoconazole (2), a known antagonist of the luteinizing hormone releasing hormone
Autor:
H. Wadsworth, David Allsop, R. Markwell, Robin V. Ward, Colin L. Masters, Eric Karran, Konrad Beyreuther, Roberto Cappai, Gary Christie, L. Smith, S. K. Gribble, Tobias Hartmann, A. Tamaoka, R. L. Gardner, D. R. Howlett, F. Mansfield, F. Godfrey, Michael R. McLaughlin, Rodney A. King, A. J. Rivett, D. G. Cooper, Carol W. Gray, Stefan F. Lichtenthaler, John R. Underwood
Publikováno v:
Journal of Neurochemistry. 73:195-204
Peptide aldehyde inhibitors of the chymotrypsin-like activity of the proteasome (CLIP) such as N-acetyl-Leu-Leu-Nle-H (or ALLN) have been shown previously to inhibit the secretion of beta-amyloid peptide (A beta) from cells. To evaluate more fully th
Publikováno v:
Foot and Ankle Surgery. 7:181-185
The incidence of tuberculosis has ceased to decline in the developing world and in some parts of the developed world. This is thought to result mainly from the increased prevalence of human immunodeficiency virus infection and the development of mult
Autor:
Milton J. Zmijewski, Nancy June Snyder, Deborah L. Mullen, Raymond E. Kaiser, Thalia I. Nicas, Robin D. G. Cooper, Barbara Shreve Briggs
Publikováno v:
The Journal of Antibiotics. 51:945-951
Novel glycopeptides derived from teicoplanin were prepared and evaluated for activity against antibiotic-resistant gram-positive pathogens. Removal of the fatty acid sidechains of teicoplanin was accomplished by enzymatic deacylation. The resulting d
Autor:
Michael John Rodriguez, Deborah L. Mullen, Robin D. G. Cooper, T. F. Butler, Thalia I. Nicas, Richard Craig Thompson, Wilkie Stephen Charles, Douglas Richard Stack, Mark James Zweifel, Nancy June Snyder
Publikováno v:
The Journal of Antibiotics. 51:560-569
LY264826 (A82846B) is a naturally-occurring glycopeptide antibiotic, differing from vancomycin in the stereochemistry of the amino-sugar of the disaccharide function, and the presence of a third sugar attached at the benzylic position of amino acid r
Autor:
Robin D. G. Cooper, Rajinder Singh
Publikováno v:
Tetrahedron. 50:12049-12064
This paper describes the synthesis of a series of 6-azabicyclo[3.2.0]hept-2-ene compounds and subsequent results obtained from biological testing, for anti-microbial potency and β-lactamase inhibition activity. It was determined that a number of com
Autor:
Robin D. G. Cooper
Publikováno v:
Bioorganic & Medicinal Chemistry. 1:1-17
The biosynthetic pathway resulting in the penicillins and cephalosporins contains two Fe 2+ oxidase enzymes which are responsible for the conversion of α-aminoadipoyl- L -cysteinyl- D -valine into isopenicillin N and penicillin N into deacetoxycepha