Zobrazeno 1 - 10
of 114
pro vyhledávání: '"D F Steiner"'
Autor:
A. Polonskaia, D. F. Steiner, Lakshmi A. Devi, M. Furuta, Yemiliya Berman, John E. Pintar, Nino Mzhavia
Publikováno v:
Journal of Neurochemistry. 75:1763-1770
Prodynorphin, a multifunctional precursor of several important opioid peptides, is expressed widely in the CNS. It is processed at specific single and paired basic sites to generate various biologically active products. Among the prohormone convertas
Autor:
N. Kaiser, E. M. Bailyes, B. S. Schneider, E. Cerasi, D. F. Steiner, J. C. Hutton, D. J. Gross
Publikováno v:
Diabetes. 46:953-957
Autor:
Natalia A. Tamarina, Michael Ludwig, Calvin L. Williams, Bin Z. He, Martin Kreitman, Bharath Arun, Sarah H. Carl, Cecelia M. Miles, Louis H. Philipson, Graeme I. Bell, Desiree A. Dickerson, Soo-Young Park, D. F. Steiner, Levi Barse
Publikováno v:
Genetics
Drosophila melanogaster has been widely used as a model of human Mendelian disease, but its value in modeling complex disease has received little attention. Fly models of complex disease would enable high-resolution mapping of disease-modifying loci
Autor:
Noriko Kimura, I Kimura, Y Sasaki, Hiroshi Nagura, Nobuaki Sasano, Yasuyuki Shimizu, D F Steiner, Kei Onodera, T Ishikawa
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 81:390-395
An autopsy case of ACTH-producing thymic carcinoid with Cushing's syndrome is reported. The patient was a 63-yr-old man with multiple bone metastases from an undetermined primary site. Hyperpigmentation was observed at the terminal stage. The plasma
Publikováno v:
Journal of Biological Chemistry. 269:32639-32648
Data presented here show that there are significant differences in the insulin binding affinity and the tyrosine kinase activity of the insulin proreceptor isoforms which contain or lack exon 11. The exon 11(+) proreceptor does not show significant v
Autor:
D. F. Steiner, Mohammad Pashmforoush, P. G. Katsoyannis, T. Kurose, Y. Yoshimasa, G. P. Schwartz, G T Burke, Ronan K. Carroll
Publikováno v:
Journal of Biological Chemistry. 269:29190-29197
To identify a site within the insulin receptor ectodomain which forms a binding pocket for B25 Phe and is responsible for initiating conformational changes required for high affinity binding of insulin we have used a novel photoreactive insulin, desp
Publikováno v:
Endocrinology. 135:31-37
The G-proteins are a family of heterotrimeric guanine nucleotide-binding proteins that play important roles in signal transduction and whose expression is regulated in a tissue-specific manner. Here we have surveyed the expression of G-protein alpha-
Autor:
D. F. Steiner, S Nagamatsu
Publikováno v:
Endocrinology. 130:748-754
The effects of glucose on insulin gene expression and proinsulin biosynthesis, processing, and secretion were studied in mouse beta TC3 cells, an established insulinoma cell line derived from transgenic mice carrying a hybrid insulin promotor-simian
Publikováno v:
Scopus-Elsevier
The biosynthesis and post-translational maturation of PC2, a neuroendocrine-specific Kex2-like endoprotease, following expression in Xenopus oocytes is described. The initial translation product was a 75-kDa membrane-associated protein which was rele
Publikováno v:
Journal of Biological Chemistry. 266:13737-13741
Islet amyloid polypeptide (IAPP) messenger RNA levels, biosynthesis, processing, and secretion were studied in cultured mouse beta TC3 insulinoma cells. Northern blot analysis revealed that the size of IAPP mRNA (0.9 kb) in beta TC3 cells was the sam