Výsledky vyhledávání

Facilitated transport of methotrexate polyglutamates into lysosomes derived from S180 cells. Further characterization and evidence for a simple mobile carrier system with broad specificity for homo- or heteropeptides bearing a C-terminal glutamyl moiety

Autor: D F O'Leary, Frank Sirotnak, J R Barrueco

Publikováno v: Journal of Biological Chemistry. 267:19986-19991

Studies are presented further characterizing a facilitative system transporting methotrexate (MTX) polyglutamates into lysosomes derived from S180 cells. Initial influx of [3H]MTX + G1 (MTX with 1 additional glutamyl residue) exhibited a slightly alk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab3739b347d89ce64f4cb4d0ec9e9e6b
https://doi.org/10.1016/s0021-9258(19)88654-4

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Metabolic turnover of methotrexate polyglutamates in lysosomes derived from S180 cells. Definition of a two-step process limited by mediated lysosomal permeation of polyglutamates and activating reduced sulfhydryl compounds

Autor: Frank Sirotnak, D F O'Leary, J R Barrueco

Publikováno v: Journal of Biological Chemistry. 267:15356-15361

Transport and metabolic turnover of methotrexate (MTX) polyglutamates were examined in lysosomes derived from S180 cells. These studies extend prior work from this laboratory (Barrueco, J. R., and Sirotnak, F. M. (1991) J. Biol. Chem 266, 11732-11737

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4d97a72df13aeefbed58587672e9104
https://doi.org/10.1016/s0021-9258(19)49541-0

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Antagonism of nitrous oxide antinociception in the rat hot plate test by site-specific mu and epsilon opioid receptor blockade

Autor: B L, Hodges, M J, Gagnon, T R, Gillespie, J R, Breneisen, D F, O'Leary, S, Hara, R M, Quock

Publikováno v: The Journal of pharmacology and experimental therapeutics. 269(2)

The analgesic property of the anesthetic gas N2O has long been known and used to treat pain in clinical medicine and dentistry. The present study was conducted to identify by subtype and possible location the brain opioid receptors that mediate N2O a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a3f07b004f28af78e4365bf901a4fa7
https://pubmed.ncbi.nlm.nih.gov/8182525

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Autor: J R, Barrueco, D F, O'Leary, F M, Sirotnak

Publikováno v: The Journal of biological chemistry. 267(28)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49421a9b82f0d6b3d5fd3a26688d0209
https://pubmed.ncbi.nlm.nih.gov/1383199

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The issues of transport multiplicity and energetics pertaining to methotrexate efflux in L1210 cells addressed by an analysis of cis and trans effects of inhibitors

Autor: F M, Sirotnak, D F, O'Leary

Publikováno v: Cancer research. 51(5)

Studies are described addressing the controversial issue of the multiplicity of efflux routes for [3H]MTX in L1210 cells. We examined efflux multiplicity under conditions that do and do not maintain cellular ATP at the physiological level. In ATP-rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e482dbbf9d28c8f9763b0f7b23dd830d
https://pubmed.ncbi.nlm.nih.gov/1997179

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The 'Detached Recollections' of Gen. D. F. O'Leary

Autor: Harold A. Koster, D. F. O'Leary, R. A. Humphreys

Publikováno v: American Quarterly. 22:287

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7e7da8394d238438b320f21e4c19830
https://doi.org/10.2307/2712130

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