Zobrazeno 1 - 10
of 65
pro vyhledávání: '"D F Jelinek"'
Autor:
Stephanie A. Smoley, R Fonseca, Esteban Braggio, Scott VanWier, Neil E. Kay, Renee C. Tschumper, Traci Sassoon, John C. Byrd, Michael T. Barrett, D F Jelinek, Tait D. Shanafelt, D L Van Dyke, Jeanette E. Eckel-Passow
Publikováno v:
Leukemia. 26:1698-1701
Longitudinal genome-wide analysis of patients with chronic lymphocytic leukemia reveals complex evolution of clonal architecture at disease progression and at the time of relapse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23131c5358f6fe7fec0262f1ca8ef9b6
https://doi.org/10.1038/leu.2012.14
https://doi.org/10.1038/leu.2012.14
Autor:
Colin L. Colby, Angela Dispenzieri, S. Vincent Rajkumar, Dirk R. Larson, Terry M. Therneau, Jerry A. Katzmann, L. Joseph Melton, D F Jelinek, Shaji Kumar, Rafael Fonseca, Arthur R. Bradwell, Raynell J. Clark, Robert A. Kyle
Publikováno v:
The Lancet. 375:1721-1728
Summary Background Monoclonal gammopathy of undetermined significance (MGUS) is defined by expression of heavy-chain immunoglobulin (IgH) and is the precursor lesion for 80% of cases of multiple myeloma. The remaining 20% are characterised by absence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f40db286a824dcd2afdb635f62d1dba
https://doi.org/10.1016/s0140-6736(10)60482-5
https://doi.org/10.1016/s0140-6736(10)60482-5
Autor:
Stephen M. Ansell, Linda Wellik, D F Jelinek, C. F. Bennett, Bonnie K. Arendt, Ellen D. Remstein, Adele K. Fielding, Deanna M. Grote, Anne J. Novak
Publikováno v:
Leukemia. 18:616-623
Survivin is a member of the inhibitor of apoptosis protein (IAP) family and functions both as an apoptosis inhibitor and a regulator of cell division. Survivin overexpression is common in many human tumors and correlates with survival in large cell n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569f950820b22b16f18dcb5511c47edd
https://doi.org/10.1038/sj.leu.2403281
https://doi.org/10.1038/sj.leu.2403281
Autor:
S. M. Ansell, Renee C. Tschumper, A Velazquez-Dones, T. E. Witzig, Kyle G. Howell, D F Jelinek, Bonnie K. Arendt
Publikováno v:
Leukemia. 16:2142-2147
Interleukin 6 (IL-6) is known to play an important role in the biology of the malignant plasma cells in multiple myeloma. In an effort to better understand IL-6 stimulated myeloma cell growth, we have performed gene expression profiling to identify I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd16dbefc8c50341502492d6aa761804
https://doi.org/10.1038/sj.leu.2402714
https://doi.org/10.1038/sj.leu.2402714
Autor:
Susan Geyer, D F Jelinek, Neil E. Kay, Nancy D. Bone, C A Hanson, Gordon W. Dewald, K. H. Howell, Renee C. Tschumper
Publikováno v:
Leukemia. 16:911-919
Initial work has shown that clonal B cells from B-chronic lymphocytic leukemia (B-CLL) are able to synthesize pro-angiogenic molecules. In this study, our goal was to study the spectrum of angiogenic factors and receptors expressed in the CLL B cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8863c5d0675161ac30dd0d91813eb7e3
https://doi.org/10.1038/sj.leu.2402467
https://doi.org/10.1038/sj.leu.2402467
Publikováno v:
The Journal of Immunology. 159:487-496
Insulin-like growth factors (IGF-I, IGF-II) have long been recognized as important mitogens in many types of malignancies. Because the role of IGFs in growth control of myeloma cells has not been extensively examined, we have used a panel of IL-6-res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::604f540974c7a03ff56ebafecf9ac14a
https://doi.org/10.4049/jimmunol.159.1.487
https://doi.org/10.4049/jimmunol.159.1.487
Autor:
K M Aagaard-Tillery, D F Jelinek
Publikováno v:
The Journal of Immunology. 157:2769-2778
Evidence supporting the importance of the 3-phosphoinositide signaling pathway in lymphocyte activation is rapidly accumulating. In our study, we assessed the effects of two PI 3-kinase inhibitors, wortmannin and LY294002, on T cells as a means to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::809465f38edfef54d637f2341c87d3a1
https://doi.org/10.4049/jimmunol.157.7.2769
https://doi.org/10.4049/jimmunol.157.7.2769
Autor:
K M Aagaard-Tillery, D F Jelinek
Publikováno v:
The Journal of Immunology. 156:4543-4554
A variety of signals, mediated via either the B cell Ag receptor (BCR), or non-BCR molecules such as CD40 or cytokine receptors, have been shown to be crucial for the regulation of B cell survival, growth, and differentiation. Although it is clear th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79948568c97881ed8ec7cb56788f4d91
https://doi.org/10.4049/jimmunol.156.12.4543
https://doi.org/10.4049/jimmunol.156.12.4543
Autor:
K M Aagaard-Tillery, D F Jelinek
Publikováno v:
The Journal of Immunology. 155:3297-3307
The state of B cell maturation profoundly influences the outcome, i.e., activation, growth arrest, or programmed cell death, of a variety of stimuli, including the calcium ionophore, ionomycin. Initial studies confirmed the observation that cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b30cf3a34fabe538f58709bdd9774e92
https://doi.org/10.4049/jimmunol.155.7.3297
https://doi.org/10.4049/jimmunol.155.7.3297
Autor:
D F Jelinek, J K Braaten
Publikováno v:
The Journal of Immunology. 154:1606-1613
The role of IL-12 in human peripheral blood B cell responsiveness was examined. To analyze the ability of IL-12 to directly mediate B cell growth and/or differentiation, FACS-purified (> 99% pure) B cells were studied and a polyclonal B cell-activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72b7b139fdd74bfac34332eb40916861
https://doi.org/10.4049/jimmunol.154.4.1606
https://doi.org/10.4049/jimmunol.154.4.1606