RAC3 more than a nuclear receptor coactivator: a key inhibitor of senescence that is downregulated in aging

Autor: Monica Alejandra Costas, M. Ruiz Grecco, D.L. Mengual Gomez, D F Alonso, Daniel E. Gomez, Laura Carolina Panelo, Maria Fernanda Rubio, Cecilia Viviana Alvarado, P. N. Fernández Larrosa

Publikováno v: Cell Death & Disease
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Receptor-associated coactivator 3 (RAC3) is a nuclear receptor coactivator usually overexpressed in tumors that exerts oncogenicfunctions in the cytoplasm and the nucleus. Although as part of its oncogenic actions it was previously identified as an i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada7e51ec2930f5159e1c7070acf1b68
https://doi.org/10.1038/cddis.2015.218

Modulation of urokinase-type plasminogen activator and metalloproteinase activities in cultured mouse mammary-carcinoma cells: enhancement by paclitaxel and inhibition by nocodazole

Autor: D F, Alonso, H G, Farina, C, Arregui, M A, Aon, D E, Gomez

Publikováno v: International journal of cancer. 83(2)

Paclitaxel is a potent anti-tumor drug used in the treatment of breast cancer. It induces de-centralization of the microtubular system in tumor cells, blocking cell division. In the search for dissemination to a secondary site, cancer cells are capab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d9c68c7e3cb59f8b3d6c99a1bef752b
https://pubmed.ncbi.nlm.nih.gov/10471534

Inhibition of mammary tumor cell adhesion, migration, and invasion by the selective synthetic urokinase inhibitor B428

Autor: D F, Alonso, A M, Tejera, E F, Farias, E, Bal de Kier Joffe, D E, Gomez

Publikováno v: Anticancer research. 18(6A)

We have analyzed the anti-invasive properties of the selective synthetic urokinase inhibitor 4-iodo benzo[b]thiopene-2-carboxamidine (B428) in the mouse mammary carcinoma model F3II. At non-cytotoxic concentrations (10-20 microM), B428 blocked secret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba981539f7b41d43ffcae2447d0e5516
https://pubmed.ncbi.nlm.nih.gov/9891516

Secretion of urokinase and metalloproteinase-9 induced by staurosporine is dependent on a tyrosine kinase pathway in mammary tumor cells

Autor: J A, Aguirre Ghiso, E F, Farías, D F, Alonso, E, Bal de Kier Joffé

Publikováno v: International journal of cancer. 76(3)

Urokinase-type plasminogen activator (uPA) is a key serine protease involved in invasion and metastasis. We had shown that overproduction of uPA in tumor cells is controlled by a phospholipase D-protein kinase C-dependent pathway. Now we studied whet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::14b1f5ad3c2a87a6b8881b85556ec544
https://pubmed.ncbi.nlm.nih.gov/9579573

A phospholipase D and protein kinase C inhibitor blocks the spreading of murine mammary adenocarcinoma cells altering f-actin and beta1-integrin point contact distribution

Autor: J A, Aguirre Ghiso, E F, Farías, D F, Alonso, C, Arregui, E, Bal de Kier Joffé

Publikováno v: International journal of cancer. 71(5)

Spreading is a critical process involved in motility and growth of tumor cells during the metastatic cascade. Focal adhesion kinase, src-proteins and PKC have been reported to participate in the regulation of cytoskeleton organization in both normal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cdab223c5fdb8d4f9b4d0c1482d50c2d
https://pubmed.ncbi.nlm.nih.gov/9180160