Zobrazeno 1 - 10
of 50
pro vyhledávání: '"D F, Bainton"'
Publikováno v:
The Journal of Immunology. 157:5085-5096
We investigated the role of neutrophil microvilli in interactions with E-selectin and P-selectin in hydrodynamic shear flow by disruption with cytochalasin B, hypotonic swelling, and chilling. Cytochalasin B only marginally reduced microvilli numbers
Publikováno v:
Blood. 88:146-157
Platelets bound to thrombogenic surfaces have been shown to support activation-dependent firm adhesion of neutrophils in flow following selectin-mediated tethering and rolling. The specific receptor(s) responsible for mediating adhesion-strengthening
Publikováno v:
Journal of Clinical Investigation. 87:919-929
To determine whether alpha-granule membranes are present in platelets of patients with storage pool deficiencies of both alpha and dense granules (alpha delta-SPD), we examined the content and surface expression of the alpha-granule membrane protein
Publikováno v:
Blood. 94(12)
Adhesion of platelets to extracellular matrix via von Willebrand factor (vWF) and activation of platelets by thrombin are critical steps in hemostasis. Glycoprotein (GP) V is a component of the GPIb-V-IX complex, the platelet receptor for vWF. GPV is
Publikováno v:
The Journal of biological chemistry. 272(9)
Platelet responses to thrombin are at least partly mediated by a G-protein-coupled receptor whose NH2 terminus is a substrate for thrombin. In the present studies we have examined the location of thrombin receptors in resting platelets and followed t
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 157(11)
We investigated the role of neutrophil microvilli in interactions with E-selectin and P-selectin in hydrodynamic shear flow by disruption with cytochalasin B, hypotonic swelling, and chilling. Cytochalasin B only marginally reduced microvilli numbers
Autor:
Richard D. Cummings, H.S. Lichenstein, D A Johnson, Fugang Li, Rodger P. McEver, D F Bainton, K D Patel, Kevin L. Moore, Richard E. Bruehl
Publikováno v:
The Journal of Cell Biology
Neutrophils roll on P-selectin expressed by activated platelets or endothelial cells under the shear stresses in the microcirculation. P-selectin glycoprotein ligand-1 (PSGL-1) is a high affinity ligand for P-selectin on myeloid cells. However, it ha
Autor:
D F, Bainton
Publikováno v:
The New England journal of medicine. 331(25)
Publikováno v:
The American journal of pathology. 144(6)
Granulophysin, a protein described in platelet dense granule membranes, has been shown to be similar or identical to CD63, a lysosomal membrane protein. We have previously shown granulophysin to be present in neutrophils using immunofluorescence. We
Publikováno v:
Blood. 82(1)
Recently, we showed that platelet alpha-granule fibrinogen is derived entirely from endocytic uptake and not from megakaryocyte synthesis, as previously thought. In this present report, we identify the receptor that mediates endocytosis. We have foun