IRF4 and BATF are critical for CD8(+) T-cell function following infection with LCMV

Autor: Haifeng C. Xu, Alisha R. Elford, Philipp A. Lang, Dieter Häussinger, Michael Lohoff, David R. McIlwain, Aleksandra A. Pandyra, Tak W. Mak, D E Speiser, Stefanie Scheu, Sathish Kumar Maney, Melanie Grusdat, Magdalena Huber, Karl S. Lang, Elisabeth Lang, Vitaly I. Pozdeev, Sarah Q. Crome, Celine Robert-Tissot, Regine J. Dress, H-W Mittrücker, J Knievel, Pamela S. Ohashi, Johannes G. Bode, Sara R. Hamilton, Klaus Pfeffer

Publikováno v: CELL DEATH AND DIFFERENTIATION
Cell Death and Differentiation, vol. 21, no. 7, pp. 1050-1060
Cell death and differentiation
Cell Death and Differentiation

CD8(+) T cell functions are critical for preventing chronic viral infections by eliminating infected cells. For healthy immune responses beneficial destruction of infected cells must be balanced against immunopathology resulting from collateral damag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2560a5c5c316b9a1e2c3e304726e9899

Vaccination of stage III/IV melanoma patients with long NY-ESO-1 peptide and CpG-B elicits robust CD8

Autor: P, Baumgaertner, C, Costa Nunes, A, Cachot, H, Maby-El Hajjami, L, Cagnon, M, Braun, L, Derré, J-P, Rivals, D, Rimoldi, S, Gnjatic, S, Abed Maillard, P, Marcos Mondéjar, M P, Protti, E, Romano, O, Michielin, P, Romero, D E, Speiser, C, Jandus

Publikováno v: Oncoimmunology. 5(10)

Long synthetic peptides and CpG-containing oligodeoxynucleotides are promising components for cancer vaccines. In this phase I trial, 19 patients received a mean of 8 (range 1–12) monthly vaccines s.c. composed of the long synthetic NY-ESO-179–10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f5bb988e9a30f844a4399887e91824ec
https://pubmed.ncbi.nlm.nih.gov/27853637

Human CD8(+) T cells expressing HLA-DR and CD28 show telomerase activity and are distinct from cytolytic effector T cells

Autor: D E, Speiser, M, Migliaccio, M J, Pittet, D, Valmori, D, Liénard, F, Lejeune, P, Reichenbach, P, Guillaume, I, Lüscher, J C, Cerottini, P, Romero

Publikováno v: European journal of immunology. 31(2)

Cycling lymphocytes may express the enzyme telomerase which is involved in maintenance of telomere length and cell proliferation potential. In CD8(+) T cells freshly isolated from peripheral blood, we found that in vivo cycling cells expressed HLA-DR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a44cf761aeda5bf69b153124c5fc13de
https://pubmed.ncbi.nlm.nih.gov/11180110

TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide-induced deletion under limited conditions

Autor: L T, Nguyen, K, McKall-Faienza, A, Zakarian, D E, Speiser, T W, Mak, P S, Ohashi

Publikováno v: European journal of immunology. 30(2)

Deletion of mature T cells maintains cellular homeostasis and is involved in the maintenance of self tolerance to some peripheral self antigens. Previous studies have presented conflicting evidence for a role of the tumor necrosis factor receptor (TN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50aca44a4c6f296a0f4f7e12878a228a
https://pubmed.ncbi.nlm.nih.gov/10671227

CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients

Autor: D E, Speiser, D, Valmori, D, Rimoldi, M J, Pittet, D, Liénard, V, Cerundolo, H R, MacDonald, J C, Cerottini, P, Romero

Publikováno v: European journal of immunology. 29(6)

In humans, NK receptors are expressed by natural killer cells and some T cells, the latter of which are preferentially alphabetaTCR+ CD8+ cytolytic T lymphocytes (CTL). In this study we analyzed the expression of nine NK receptors (p58.1, p58.2, p70,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d045d259df4308d07063f15b0c74428
https://pubmed.ncbi.nlm.nih.gov/10382762