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CD4+ T cells from IRF-1-deficient mice exhibit altered patterns of cytokine expression and cell subset homeostasis

Autor: D L McElligott, J A Phillips, C A Stillman, R J Koch, D E Mosier, M V Hobbs

Publikováno v: The Journal of Immunology. 159:4180-4186

Interferon regulatory factor-1 (IRF-1) is a member of a family of transcription factors that regulate an array of genes involved in cell growth, differentiation, and death. Analysis of cytokine expression by stimulated CD4+ cells from IRF-1(-/-) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::602cad4794eb355ec6a2d5e501da1b4a
https://doi.org/10.4049/jimmunol.159.9.4180

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Apoptosis induced by HIV infection in H9 T cells is blocked by ICE-family protease inhibition but not by a Fas(CD95) antagonist

Autor: J M Glynn, D L McElligott, D E Mosier

Publikováno v: The Journal of Immunology. 157:2754-2758

Infection of human CD4-positive T lymphocytes by human immunodeficiency virus type 1 (HIV-1) is thought to lead to death of infected cells by apoptosis, although one recent report questions this conclusion. Here we demonstrate that HIV-1-induced apop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf6964652b2dfb04a818f236019343a3
https://doi.org/10.4049/jimmunol.157.7.2754

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Cloned human CD8+ cytotoxic T lymphocytes protect human peripheral blood leukocyte-severe combined immunodeficient mice from HIV-1 infection by an HLA-unrestricted mechanism

Autor: R van Kuyk, B E Torbett, R J Gulizia, S Leath, D E Mosier, S Koenig

Publikováno v: The Journal of Immunology. 153:4826-4833

The ability to infect human peripheral blood leukocyte-reconstituted severe combined immunodeficient (hu-PBL-SCID) mice with HIV has allowed evaluation of several strategies for preventing or treating infection. In one study, hu-PBL-SCID mice derived

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a5b51931c55f1f807e760846ef49141
https://doi.org/10.4049/jimmunol.153.10.4826

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LP-BM5 murine retrovirus-induced immunodeficiency disease in allogeneic SCID chimeric mice. Inability to recognize a putative viral superantigen does not prevent induction of disease

Autor: G L Gilmore, C Cowing, D E Mosier

Publikováno v: The Journal of Immunology. 150:185-189

T cell recognition of viral superantigens has been postulated to contribute to the pathogenesis of the immunodeficiency disease induced in mice by infection with the LP-BM5 murine leukemia virus complex. A candidate superantigen has been identified i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a3a5ba1947a4c4b9a292200dee15328
https://doi.org/10.4049/jimmunol.150.1.185

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CD4+CD8- thymocytes from neonatal mice induce IgM production in SCID mice

Autor: J E Riggs, M V Hobbs, D E Mosier

Publikováno v: The Journal of Immunology. 148:1389-1395

Defective recombination of both the TCR and Ig genes results in the absence of mature lymphocytes in mice with the scid mutation. We have shown previously that the transfer of neonatal, but not adult, thymocytes results in high levels of Ig productio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f24656911c9de0c67d1ca3953a5f3d65
https://doi.org/10.4049/jimmunol.148.5.1389

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The antiviral activity of HIV-specific CD8+ CTL clones is limited by elimination due to encounter with HIV-infected targets

Autor: D M, McKinney, D A, Lewinsohn, S R, Riddell, P D, Greenberg, D E, Mosier

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(2)

Adoptive immunotherapy of virus infection with viral-specific CTL has shown promise in animal models and human virus infections and is being evaluated as a therapy for established HIV-1 infection. Defining the individual obstacles for success is diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e81e9f802ac0d194b12ed3d0ebe857b3
https://pubmed.ncbi.nlm.nih.gov/10395680

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