Výsledky vyhledávání

PHLDA2 is an imprinted gene in cattle

Autor: K M, Sikora, D A, Magee, E W, Berkowicz, P, Lonergan, A C O, Evans, F, Carter, A, Comte, S M, Waters, D E, MacHugh, C, Spillane

Publikováno v: Animal genetics. 43(5)

Genomic imprinting is an epigenetic non-Mendelian phenomenon found predominantly in placental mammals. Imprinted genes display differential expression in the offspring depending on whether the gene is maternally or paternally inherited. Currently, so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0abde0a38040fee1c697538f301332a1
https://pubmed.ncbi.nlm.nih.gov/22497461

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Single nucleotide polymorphisms in the imprinted bovine insulin-like growth factor 2 receptor gene (IGF2R) are associated with body size traits in Irish Holstein-Friesian cattle

Autor: E W, Berkowicz, D A, Magee, D P, Berry, K M, Sikora, D J, Howard, M P, Mullen, R D, Evans, C, Spillane, D E, MacHugh

Publikováno v: Animal genetics. 43(1)

The regulation of the bioavailability of insulin-like growth factors (IGFs) is critical for normal mammalian growth and development. The imprinted insulin-like growth factor 2 receptor gene (IGF2R) encodes a transmembrane protein receptor that acts t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3747cb3c1f4d932884c5e8820521bf1a
https://pubmed.ncbi.nlm.nih.gov/22221028

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Targets of selection in the Thoroughbred genome contain exercise-relevant gene SNPs associated with elite racecourse performance

Autor: E W, Hill, J, Gu, B A, McGivney, D E, MacHugh

Publikováno v: Animal genetics. 41

Athletic performance is influenced by a complex interplay among the environment and a suite of genes, which contributes to system-wide structure and function. In a panel of elite and non-elite Thoroughbred horses (n=148), we genotyped 68 SNPs in 17 p

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https://pubmed.ncbi.nlm.nih.gov/21070277

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Genome-wide SNP association-based localization of a dwarfism gene in Friesian dwarf horses

Autor: N, Orr, W, Back, J, Gu, P, Leegwater, P, Govindarajan, J, Conroy, B, Ducro, J A M, Van Arendonk, D E, MacHugh, S, Ennis, E W, Hill, P A J, Brama

Publikováno v: Animal genetics. 41

The recent completion of the horse genome and commercial availability of an equine SNP genotyping array has facilitated the mapping of disease genes. We report putative localization of the gene responsible for dwarfism, a trait in Friesian horses tha

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https://pubmed.ncbi.nlm.nih.gov/21070269

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Association of sequence variants in CKM (creatine kinase, muscle) and COX4I2 (cytochrome c oxidase, subunit 4, isoform 2) genes with racing performance in Thoroughbred horses

Autor: J, Gu, D E, MacHugh, B A, McGivney, S D E, Park, L M, Katz, E W, Hill

Publikováno v: Equine veterinary journal. Supplement. (38)

The wild progenitors of the domestic horse were subject to natural selection for speed and stamina for millennia. Uniquely, this process has been augmented in Thoroughbreds, which have undergone at least 3 centuries of intense artificial selection fo

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https://pubmed.ncbi.nlm.nih.gov/21059062

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Moderate and high intensity sprint exercise induce differential responses in COX4I2 and PDK4 gene expression in Thoroughbred horse skeletal muscle

Autor: E W, Hill, S S, Eivers, B A, McGivney, R G, Fonseca, J, Gu, N A, Smith, J A, Browne, D E, MacHugh, L M, Katz

Publikováno v: Equine veterinary journal. Supplement. (38)

The role of molecular signalling pathways in the phenotypic adaptation of skeletal muscle to different exercise stimuli in the Thoroughbred horse has not been reported previously.To examine CKM, COX4I1, COX4I2 and PDK4 gene expression following high

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https://pubmed.ncbi.nlm.nih.gov/21059063

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Technical note: High fidelity of whole-genome amplified sheep (Ovis aries) deoxyribonucleic acid using a high-density single nucleotide polymorphism array-based genotyping platform

Autor: D A, Magee, S D E, Park, E, Scraggs, A M, Murphy, M L, Doherty, J W, Kijas, D E, MacHugh

Publikováno v: Journal of animal science. 88(10)

Advances in high-throughput genotyping technologies have afforded researchers the opportunity to study ever-increasing numbers of SNP in animal genomes. However, many studies encounter difficulties in obtaining sufficient quantities of high-quality D

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https://pubmed.ncbi.nlm.nih.gov/20562352

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Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle

Autor: S M, Waters, M S, McCabe, D J, Howard, L, Giblin, D A, Magee, D E, MacHugh, D P, Berry

Publikováno v: Animal genetics. 42(1)

Variations in the growth hormone receptor (GHR) gene sequence are associated with performance traits in cattle. For example, the single nucleotide polymorphism (SNP) F279Y in transmembrane exon 8 has a strong association with milk yield. In this stud

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https://pubmed.ncbi.nlm.nih.gov/20528848

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Taurine and zebu admixture in Near Eastern cattle: a comparison of mitochondrial, autosomal and Y-chromosomal data

Autor: C J, Edwards, J F, Baird, D E, MacHugh

Publikováno v: Animal genetics. 38(5)

Eight Bos taurus cattle breeds from the Near East region were screened with a Bos indicus (zebu)-diagnostic Y-specific microsatellite (INRA124) to estimate the proportion of zebu Y chromosomes in each population. This value was compared with previous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4f6d3f3e32bf0b021d8b26cfbb79fd6d
https://pubmed.ncbi.nlm.nih.gov/17725685

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