Zobrazeno 1 - 10
of 12
pro vyhledávání: '"D E Lenz"'
Publikováno v:
International Journal of Toxicology. 15:69-77
An animal model was developed to examine the pharmacology of the highly toxic organophosphorus compound (OP) ethyl-S-diisopropylaminoethyl methylphosphonothiolate (VX) in rats after a subacute exposure in the absence of supporting therapy, such as at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::024c66c07ed9b3ec90ed5fb1af465190
https://doi.org/10.3109/10915819609048339
https://doi.org/10.3109/10915819609048339
Autor:
D M, Cerasoli, E M, Griffiths, B P, Doctor, A, Saxena, J M, Fedorko, N H, Greig, Q S, Yu, Y, Huang, H, Wilgus, C N, Karatzas, I, Koplovitz, D E, Lenz
Publikováno v:
Chemico-biological interactions.
Previous studies in rodents and nonhuman primates have demonstrated that pretreatment with cholinesterases can provide significant protection against behavioral and lethal effects of nerve agent intoxication. Human butyrylcholinesterase (HuBuChE) pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a72eefdfe509b68cfaac59bb0669b330
https://pubmed.ncbi.nlm.nih.gov/16429486
https://pubmed.ncbi.nlm.nih.gov/16429486
Publikováno v:
Journal of applied toxicology : JAT. 16(1)
The neurotoxicity of organophosphorus (OP) compounds involves the inhibition of acetylcholinesterase (AChE), causing accumulation of acetylcholine (ACh) at synapses. However, cholinergic crisis may not be the sole mechanism of OP toxicity. Adverse dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc7bc001f86c9ba923958ba3f75f301d
https://pubmed.ncbi.nlm.nih.gov/8821672
https://pubmed.ncbi.nlm.nih.gov/8821672
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 259(2)
Butyrylcholinesterase (BuChE) was examined as an in vivo exogenous scavenger for highly toxic organophosphorus (OP) poisons. Protection studies with equine BuChE were carried out in rhesus monkeys trained to perform a Serial Probe Recognition task. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f8c982f64914c0e5d37e22ff87b65cc6
https://pubmed.ncbi.nlm.nih.gov/1941611
https://pubmed.ncbi.nlm.nih.gov/1941611
Publikováno v:
Journal of submicroscopic cytology and pathology. 23(2)
Soman, an organophosphorous irreversible inhibitor of acetylcholinesterase, was studied for its effect on the rat blood-brain barrier (BBB) during the first 24 h of intoxication. Young adult male Sprague-Dawley rats, injected with Evans blue-dye and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f376468fd9a77de774b73e0ca47995d
https://pubmed.ncbi.nlm.nih.gov/2070359
https://pubmed.ncbi.nlm.nih.gov/2070359
Autor:
Michael A. Riel, R. K. Gordon, R. E. Clawson, G. E. Garcia, J. R. Haigh, C. R. Clark, R. P. Brueckner, D. E. Lenz
Publikováno v:
Clinical Pharmacology & Therapeutics. 75:P87
Background RBC acetylcholinesterase (AChE) and serum butyrylcholinesterase (BChE) inhibition are considered good biomarkers for protection against exposure to nerve agents. These enzymes may be sequestered (reversibly bound) by pyridostigmine bromide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::529d3733ea075790ced3b3cd74ab80ce
https://doi.org/10.1016/j.clpt.2003.11.332
https://doi.org/10.1016/j.clpt.2003.11.332
Publikováno v:
Journal of Applied Toxicology; May2003, Vol. 23 Issue 3, p177-186, 10p
Autor:
D. E. LENZ, A. A. BRIMFIELD, K. W. HUNTER, H. P. BENSCHOP, L. P. A. DE JONG, C. VAN DUK, T. R. CLOW
Publikováno v:
Toxicological Sciences. 4:156-164
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2002941b2e762f952c7ec504ba58509
https://doi.org/10.1093/toxsci/4.2part2.156
https://doi.org/10.1093/toxsci/4.2part2.156
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 4(2 Pt 2)
The production of antibodies against the organophosphorus hapten soman has been undertaken in vivo in rabbits and in vitro by employing monoclonal techniques. The polyclonal rabbit antibodies did not cross-react with soman but were inhibited by soman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91b9fafef655a397746d683bf6de43a7
https://pubmed.ncbi.nlm.nih.gov/6724207
https://pubmed.ncbi.nlm.nih.gov/6724207
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 246(3)
The ability of the carbamates pyridostigmine and physostigmine to protect against the lethal effects of soman, an extremely toxic anticholinesterase agent, was measured in rats, guinea pigs and rabbits. Pharmacologically equivalent doses of these car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27fea8a4e630ea839403de55ddc2b093
https://pubmed.ncbi.nlm.nih.gov/3418520
https://pubmed.ncbi.nlm.nih.gov/3418520