Partitioning of an Enzyme-Polymer Surfactant Nanocomplex into Lipid-Rich Cellular Compartments Drives In Situ Hydrolysis of Organophosphates.

Autor: Carter BM; School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK., Day GJ; School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK., Zhang WH; School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK., Sessions RB; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK., Jackson CJ; Research School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Australian National University, Canberra, ACT, 2601, Australia., Perriman AW; School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK.; Research School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia.; John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia.

Publikováno v: Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Nov; Vol. 20 (44), pp. e2401982. Date of Electronic Publication: 2024 Jul 11.

In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger

Autor: D M, Cerasoli, E M, Griffiths, B P, Doctor, A, Saxena, J M, Fedorko, N H, Greig, Q S, Yu, Y, Huang, H, Wilgus, C N, Karatzas, I, Koplovitz, D E, Lenz

Publikováno v: Chemico-biological interactions.

Previous studies in rodents and nonhuman primates have demonstrated that pretreatment with cholinesterases can provide significant protection against behavioral and lethal effects of nerve agent intoxication. Human butyrylcholinesterase (HuBuChE) pur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a72eefdfe509b68cfaac59bb0669b330
https://pubmed.ncbi.nlm.nih.gov/16429486

Protection by butyrylcholinesterase against organophosphorus poisoning in nonhuman primates

Autor: C A, Broomfield, D M, Maxwell, R P, Solana, C A, Castro, A V, Finger, D E, Lenz

Publikováno v: The Journal of pharmacology and experimental therapeutics. 259(2)

Butyrylcholinesterase (BuChE) was examined as an in vivo exogenous scavenger for highly toxic organophosphorus (OP) poisons. Protection studies with equine BuChE were carried out in rhesus monkeys trained to perform a Serial Probe Recognition task. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8c982f64914c0e5d37e22ff87b65cc6
https://pubmed.ncbi.nlm.nih.gov/1941611

The effect of oral pyridostigmine bromide on the recovery of whole blood cholinesterase activity following ex vivo exposure to soman

Autor: Michael A. Riel, R. K. Gordon, R. E. Clawson, G. E. Garcia, J. R. Haigh, C. R. Clark, R. P. Brueckner, D. E. Lenz

Publikováno v: Clinical Pharmacology & Therapeutics. 75:P87

Background RBC acetylcholinesterase (AChE) and serum butyrylcholinesterase (BChE) inhibition are considered good biomarkers for protection against exposure to nerve agents. These enzymes may be sequestered (reversibly bound) by pyridostigmine bromide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::529d3733ea075790ced3b3cd74ab80ce
https://doi.org/10.1016/j.clpt.2003.11.332