Zobrazeno 1 - 10
of 71
pro vyhledávání: '"D E, Reed"'
Autor:
C. J. Tuck, G. De Palma, K. Takami, B. Brant, A. Caminero, D. E. Reed, J. G. Muir, P. R. Gibson, A. Winterborn, E. F. Verdu, P. Bercik, S. Vanner
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract The lack of reproducibility of animal experimental results between laboratories, particularly in studies investigating the microbiota, has raised concern among the scientific community. Factors such as environment, stress and sex have been i
Externí odkaz:
https://doaj.org/article/708e388632bb4a2ca819b845f223579c
Autor:
C E Degro, N N Jiménez-Vargas, H M Schincariol, Q K Tsang, M Guzman-Rodriguez, A E Lomax, D E Reed, C Stein, N W Bunnett, S J Vanner
Publikováno v:
Journal of the Canadian Association of Gastroenterology. 6:90-91
Background Adequate pain control in inflammatory bowel disease (IBD) can require opioids due to their high analgesic potency. The long-term use of opioids, however, is limited by the development of tolerance. This leads to reduced analgesic efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec0dcbdd5db36f089fdf65a71874a203
https://doi.org/10.1093/jcag/gwac036.277
https://doi.org/10.1093/jcag/gwac036.277
Publikováno v:
Journal of the Canadian Association of Gastroenterology. 6:94-95
Background Food and stress are common triggers of symptoms in IBS patients. We previously showed in a murine model of IBS that exposure to a food antigen during a period of psychological stress leads to visceral hypersensitivity in both the ileum and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5db98c0e5a585029ef68abe9fe62de81
https://doi.org/10.1093/jcag/gwac036.283
https://doi.org/10.1093/jcag/gwac036.283
Publikováno v:
Journal of the Canadian Association of Gastroenterology. 6:1-2
Background Abdominal pain is a debilitating symptom in patients with inflammatory bowel disease. Previously we have shown that both cannabinoid-1 receptor (CB1R) and mu opioid receptor (MOR) agonists inhibit mechanosensitivity of colonic nociceptive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aef56d622934f05675f90b2b3e663b17
https://doi.org/10.1093/jcag/gwac036.002
https://doi.org/10.1093/jcag/gwac036.002
Publikováno v:
Journal of the Canadian Association of Gastroenterology. 6:91-92
Background Abdominal pain is a primary symptom of inflammatory bowel disease (IBD). Opioids provide relief from IBD-associated pain, but they are addictive and associated with excess mortality in IBD patients. Thus, there is a need to develop novel t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55e4ca00449ffcee055d074e96772a44
https://doi.org/10.1093/jcag/gwac036.279
https://doi.org/10.1093/jcag/gwac036.279
Publikováno v:
Journal of the Canadian Association of Gastroenterology. 3:13-15
Background Irritable bowel syndrome (IBS) patients are subtyped by predominant bowel habit rather than pathophysiological mechanisms and this may underlie challenges in identifying more effective targets for designing new treatments. Metabolomics and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1cfbba8a1fa3e6a158b0aae26a8f33a
https://doi.org/10.1093/jcag/gwz047.010
https://doi.org/10.1093/jcag/gwz047.010
Publikováno v:
Journal of the Canadian Association of Gastroenterology. 5:92-93
Background Anecdotal reports suggest that access to pH/motility testing is problematic in Canada, but to date there is little data documenting this. Aims To assess the volume and accessibility of motility lab testing in Canada. Methods The CNN develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69bfd55f67b43d051885a72c8b7df055
https://doi.org/10.1093/jcag/gwab049.079
https://doi.org/10.1093/jcag/gwab049.079
Publikováno v:
Journal of the Canadian Association of Gastroenterology. 5:131-132
Background Previously we have shown that both cannabinoid 1 receptor (CB1R) and mu-opioid receptor (MOR) agonists inhibit mechanosensitivity of colonic nociceptive nerves. However, it is unknown whether agonists of cannabinoid and opioid receptors ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33fdf39c48f3f801b271664640086d8b
https://doi.org/10.1093/jcag/gwab049.238
https://doi.org/10.1093/jcag/gwab049.238
Autor:
C E Degro, N N Jiménez-Vargas, Q K Tsang, Y Yu, C Stein, N W Bunnett, A E Lomax, D E Reed, S Vanner
Publikováno v:
Journal of the Canadian Association of Gastroenterology. 5:61-62
Background Opioids provide effective pain relief during flares of inflammatory bowel disease but are limited by serious side effects. We showed that acute administration of a novel pH-sensitive opioid agonist, NFEPP, had potent analgesic effects in i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56d63ccf9ff88788ff10d5d303119257
https://doi.org/10.1093/jcag/gwab049.052
https://doi.org/10.1093/jcag/gwab049.052
Publikováno v:
Journal of the Canadian Association of Gastroenterology. 5:134-135
Background We have shown that Irritable Bowel Syndrome diarrhea-predominant (IBS-D) patients with a history of a dysbiotic-like onset have distinct stool metabolomic profiles versus those with a non-dysbiotic-like onset. IBS stool supernatants can se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91106838d1d56c9aad3cb38afd8433a0
https://doi.org/10.1093/jcag/gwab049.241
https://doi.org/10.1093/jcag/gwab049.241