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Clomiphene Prevents Cancellous Bone Loss from Tibia of Ovariectomized Rats

Autor: D. E. Magee, Russell T. Turner, H. U. Bryant, M. A. Jimenez

Publikováno v: Endocrinology. 138:1794-1800

Estrogen inhibits postmenopausal bone loss and decreases fracture risk. Unfortunately, estrogen replacement therapy has many undesirable side effects, the majority of which are due to stimulation of reproductive tissues. Tissue specific estrogen agon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a552337329f6ce57019f102dd31727b4
https://doi.org/10.1210/endo.138.5.5109

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The effects of raloxifene on tibia histomorphometry in ovariectomized rats

Autor: Masahiko Sato, D. E. Magee, Glenda L. Evans, Russell T. Turner, H. U. Bryant

Publikováno v: Endocrinology. 134:2283-2288

Tissue-specific estrogen agonists may be useful in protecting against osteoporosis and the increased risk of coronary heart disease in postmenopausal women with minimal undesired effects on reproductive tissues. The actions of the mixed estrogen agon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32dfe09c061517c0dd3ed7b078205e85
https://doi.org/10.1210/endo.134.5.8156931

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Effects of prolonged ethinyl estradiol treatment on calcium channel binding and in vivo calcium-mediated hemodynamic responses in ovariectomized rats

Autor: N, Bowling, W E, Bloomquist, M L, Cohen, H U, Bryant, H W, Cole, D E, Magee, E R, Rowley, C J, Vlahos

Publikováno v: The Journal of pharmacology and experimental therapeutics. 281(1)

Ethinyl estradiol (EE2), administered orally to ovariectomized (ovex) rats, has been shown to prevent loss of bone mineral density and to decrease serum cholesterol levels. Radioligand binding studies with the dihydropyridine (DHP) [3H]PN200-110 were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b64acaa6d653872e33cad558d826e42c
https://pubmed.ncbi.nlm.nih.gov/9103500

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Rapid tumor development with a modified MCF-7 xenograft model

Autor: L V, Hale, N K, Layman, P, Wilson, L L, Short, D E, Magee, S R, Wightman, R, Fuchs-Young

Publikováno v: Laboratory animal science. 47(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac9b3b521ccfb650ea62f6402f6c569f
https://pubmed.ncbi.nlm.nih.gov/9051652

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Raloxifene inhibits bone turnover and prevents further cancellous bone loss in adult ovariectomized rats with established osteopenia

Autor: H. U. Bryant, Glenda L. Evans, D. E. Magee, Russell T. Turner

Publikováno v: Endocrinology. 137(10)

Estrogen (E) treatment has proven to be effective in preventing bone loss after menopause with, however, some undesirable side effects. Many of these side effects are related to the hormone's actions on reproductive tissues. Raloxifene is an organ-se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f7e7708d390faee60320ab75247001
https://pubmed.ncbi.nlm.nih.gov/8828469

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Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats

Autor: Raymond F. Kauffman, D C Williams, A Bekele, E R Rowley, W R Bensch, R Bendele, Larry John Black, D E Magee, Masahiko Sato, G J Cullinan

There is a medical need for an agent with the positive effects of estrogen on bone and the cardiovascular system, but without the negative effects on reproductive tissue. Raloxifene (LY139481 HCI) is a benzothiophene derivative that binds to the estr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6238e4e6c949a9bb93215c390e1cf6
https://europepmc.org/articles/PMC293730/

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Binding of a radioiodinated agonist to thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptors in guinea pig lung membranes

Autor: D E, Mais, D L, Saussy, D E, Magee, C M, Williams

Publikováno v: Advances in prostaglandin, thromboxane, and leukotriene research.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::901fe1e34f45583a9df3bc4bef1802c8
https://pubmed.ncbi.nlm.nih.gov/1825567

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Characterization of a thromboxane A2/prostaglandin H2 receptor in guinea pig lung membranes using a radioiodinated thromboxane mimetic

Autor: D L, Saussy, D E, Mais, G P, Dubé, D E, Magee, K A, Brune, W L, Kurtz, C M, Williams

Publikováno v: Molecular pharmacology. 39(1)

Thromboxane A2 (TXA2) and prostaglandin H2 (PGH2) are potent constrictors of airway smooth muscle and may mediate some of the pulmonary effects of leukotrienes. To date, the TXA2/PGH2 receptor in lung has not been well characterized. In this report,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7beafd082cdab782b42c41f6c1b5cab8
https://pubmed.ncbi.nlm.nih.gov/1824791

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Interaction of 5-HETE, 12-HETE, 15-HETE and 5,12-diHETE at the human platelet thromboxane A2/prostaglandin H2 receptor

Autor: D E, Mais, D L, Saussy, D E, Magee, N L, Bowling

Publikováno v: Eicosanoids. 3(2)

A variety of lipoxygenase products such as 12- and 15-hydroxyeicosatetraenoic acid (12- and 15-HETE) inhibit thromboxane A2 (TXA2) mimetic induced human platelet aggregation in a stereoselective manner. The mechanism of this inhibition remains unclea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb4717bf963b745b7b7f6f83db3a538b
https://pubmed.ncbi.nlm.nih.gov/2169775

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