Zobrazeno 1 - 10 of 63 pro vyhledávání: '"D E, MacFarlane"'
1
Pharmacokinetics and safety of OBI-1, a recombinant B domain-deleted porcine factor VIII, in subjects with haemophilia A
Autor: C L, Kempton, T C, Abshire, R A, Deveras, W K, Hoots, J C, Gill, C M, Kessler, N S, Key, B A, Konkle, P, Kuriakose, D E, Macfarlane, G, Bergman
Publikováno v: Haemophilia : the official journal of the World Federation of Hemophilia. 18(5)
OBI-1 is a recombinant B-domain deleted porcine factor VIII (FVIII). FVIII treatment in those with haemophilia A may be complicated by the development of anti-FVIII antibodies (inhibitors) leading to a failure to respond to treatment with human FVIII
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c177bdc9fb129573c7270828b96a62f
https://pubmed.ncbi.nlm.nih.gov/22512291
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2
Activation of beta-isozyme of protein kinase C (PKC beta) is necessary and sufficient for phorbol ester-induced differentiation of HL-60 promyelocytes. Studies with PKC beta-defective PET mutant
Autor: L Manzel, D E Macfarlane
Publikováno v: Journal of Biological Chemistry. 269:4327-4331
12-O-Tetradecanoylphorbol-13-acetate (TPA) induces growth arrest and differentiation of a number of leukemia cell lines including HL-60 human promyelocytic leukemia. We investigated the involvement of protein kinase C (PKC) isotypes in phorbol ester-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd0145a5938a3d9937314a5e29d4eb71
https://doi.org/10.1016/s0021-9258(17)41782-0
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3
Antagonism of immunostimulatory CpG-oligodeoxynucleotides by 4-aminoquinolines and other weak bases: mechanistic studies
Autor: L, Manzel, L, Strekowski, F M, Ismail, J C, Smith, D E, Macfarlane
Publikováno v: The Journal of pharmacology and experimental therapeutics. 291(3)
Oligodeoxynucleotides with unmethylated CpG motifs are immunostimulatory. Chloroquine and a number of structural analogs specifically and powerfully inhibit this effect at nanomolar concentrations. We explored the mechanism of this inhibition, with 4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::71c2cb4669eecff2453d062ba6544992
https://pubmed.ncbi.nlm.nih.gov/10565859
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6
Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds
Autor: D E, Macfarlane, L, Manzel
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 160(3)
Phosphorothioate oligodeoxynucleotides containing CpG (CpG-ODN) activate immune responses. We report that quinacrine, chloroquine, and structurally related compounds completely inhibit the antiapoptotic effect of CpG-ODN on WEHI 231 murine B lymphoma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2fba89842f94bab6e8da856c89f39262
https://pubmed.ncbi.nlm.nih.gov/9570525
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7
Unmethylated CpG-containing oligodeoxynucleotides inhibit apoptosis in WEHI 231 B lymphocytes induced by several agents: evidence for blockade of apoptosis at a distal signalling step
Autor: L. Manzel, Arthur M. Krieg, D. E. Macfarlane
Certain oligodeoxynucleotides (ODN) containing cytosine followed by guanosine (CpG) protect B cells from apoptosis, and induce B-cell proliferation and cytokine production. We investigated the effect of phosphorothioate CpG-containing ODNs (5'-ATAATC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05596b95cea21f8db0d016cc70fd99b7
https://europepmc.org/articles/PMC1363880/
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8
Efficacy and safety of enoxaparin to prevent deep venous thrombosis after hip replacement surgery. Enoxaparin Clinical Trial Group
Autor: T E, Spiro, G J, Johnson, M J, Christie, R M, Lyons, D E, MacFarlane, R B, Blasier, M D, Tremaine
Publikováno v: Annals of internal medicine. 121(2)
To determine the most effective and safe dose of enoxaparin to prevent deep venous thrombosis in high-risk surgical patients.A double-blind, randomized, multicenter clinical trial.Private, university, and government hospitals in the United States.572
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0cf69662dd5e1654373af93000c2b0e3
https://pubmed.ncbi.nlm.nih.gov/8017740
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9
Activation of beta-isozyme of protein kinase C (PKC beta) is necessary and sufficient for phorbol ester-induced differentiation of HL-60 promyelocytes. Studies with PKC beta-defective PET mutant
Autor: D E, Macfarlane, L, Manzel
Publikováno v: The Journal of biological chemistry. 269(6)
12-O-Tetradecanoylphorbol-13-acetate (TPA) induces growth arrest and differentiation of a number of leukemia cell lines including HL-60 human promyelocytic leukemia. We investigated the involvement of protein kinase C (PKC) isotypes in phorbol ester-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b56975c501b3d8de52101400bd71ca7
https://pubmed.ncbi.nlm.nih.gov/8308000
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10
Isolation of RNA from cells in culture using Catrimox-14 cationic surfactant
Autor: C E, Dahle, D E, Macfarlane
Publikováno v: BioTechniques. 15(6)
Traditional RNA isolation methods use chaotropic agents and anionic detergents to lyse cells and solubilize nucleic acids. In contrast, the cationic surfactant, Catrimox-14, lyses cells and simultaneously precipitates RNA, thereby protecting it from
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ec3360c48ef7126356fdff8d71a359e
https://pubmed.ncbi.nlm.nih.gov/8292344
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