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Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in human plasma

Autor: F. A. Brightman, D. E. Leahy, G. E. Searle, S. Thomas

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 34(1)

Estimation of xenobiotic kinetics in humans frequently relies upon extrapolation from experimental data generated in animals. In an accompanying paper, we have presented a unique, generic, physiologically based pharmacokinetic model and described its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5650e05332e8c86dd30470d953ab5867
https://pubmed.ncbi.nlm.nih.gov/16221756

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Prediction of in vivo tissue distribution from in vitro data 1. Experiments with markers of aqueous spaces

Autor: P, Ballard, D E, Leahy, M, Rowland

Publikováno v: Pharmaceutical research. 17(6)

The aim of this study was to evaluate the ability of an in vitro method of tissue distribution to accurately predict total water and extracellular aqueous spaces using marker compounds urea and inulin.Slices (50-200 mg) of all the major tissues in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a5162406e6cff9fab6681d24a9e99c83
https://pubmed.ncbi.nlm.nih.gov/10955837

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Estimation of sieving coefficients of convective absorption of drugs in perfused rat jejunum

Autor: D. E. Leahy, R. E. Finney, D. C. Taylor, J. Lynch

Publikováno v: Journal of pharmacokinetics and biopharmaceutics. 22(5)

Intestinal absorption of many hydrophilic drugs cannot be explained solely in terms of pH-partition and solvent-drag effects have been described in a number of cases. However, quantitative estimates of sieving coefficient (phi) for drug molecules hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e846d1264896b6442fbe6796f6d5b6d
https://pubmed.ncbi.nlm.nih.gov/7791039

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Basicities and Tautomerism of Substituted Methano-bridged Aza[10]annulenes: 10p-Analogues of Pyridine

Autor: B. Mancheno, Alan R. Katritzky, D. E. Leahy

Publikováno v: HETEROCYCLES. 36:2483

pKa values of substituted 2,7-methanoaza[10]annulenes are measured and compared with similarly substituted pyridines. The tautomerism of 2-azabicyclo[4,4,1]undeca-4,6,8,10-tetraen-3-one is discussed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5821a061ae27a1acccdcc58b103ce2d7
https://doi.org/10.3987/com-93-6460

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