Zobrazeno 1 - 10 of 172 pro vyhledávání: '"D E, Hughes"'
1
Interleukin-6 does not stimulate bone resorption in neonatal mouse calvariae
Autor: Stuart H. Ralston, Karen Chapman, R. Graham G. Russell, D. E. Hughes, Lucien Aarden, Maxine Gowen, Abdul-Karim Al-Humidan
Publikováno v: Journal of Bone and Mineral Research. 6:3-8
Recombinant human interleukin-6 (IL-6) was assessed for its ability to stimulate bone resorption in prelabeled mouse calvariae in vitro. IL-6 had no effect on bone resorption at concentrations ranging from 300 to 10,000 U/ml (3-1000 pg/ml). Neither t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463ed3f5d79b66d6bf10ec2877bd5fab
https://doi.org/10.1002/jbmr.5650060103
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2
The application of hypervirial relations to periodic potentials
Autor: C. J. Bradley, D. E. Hughes
Publikováno v: International Journal of Quantum Chemistry. 1:687-701
An investigation is made of the application of hypervirial relations to problems involving periodic potentials. Necessary and sufficient conditions are established for both diagonal and off-diagonal hypervirial relations to yield solutions of the Sch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41b7e2eb1d1fb604f1177b8f7f66c354
https://doi.org/10.1002/qua.560010675
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4
Intramedullary and extramedullary fat globules on magnetic resonance imaging as a diagnostic sign for osteomyelitis
Autor: D. E. Hughes, R. J. Grimer, A. M. Davies
Publikováno v: European Radiology. 15:2194-2199
We retrospectively studied the frequency of persistent foci of fat signal on magnetic resonance (MR) imaging in osteomyelitis to assess its frequency, cause and diagnostic value. The radiographs and MR scans of 100 patients with a final diagnosis of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0875b2e057623868543d47ecaf8f8595
https://doi.org/10.1007/s00330-005-2771-4
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5
The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters
Autor: S P Lichtsteiner, D E Hughes, Alain P. Vasserot, Zhuo Wang, Jane S. Lebkowski, A S Majumdar
Publikováno v: Gene Therapy. 8:568-578
In human cells, telomerase activity is regulated by transcriptional control of the telomerase reverse transcriptase gene (hTERT) whose product is the catalytic subunit of the enzyme. The hTERT promoter is active in virtually all types of tumors and i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18e0ff68ec920f8935af4f349cbe41f
https://doi.org/10.1038/sj.gt.3301421
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6
A taxonomic and ecological study of candidosis
Autor: Alan J. Griffiths, J. Turner, D. E. Hughes, A. C. Srivastava
Publikováno v: Microbial ecology. 11(1)
A total of 450 yeast isolates were obtained from up to 34 sites on 59 human subjects. The yeasts were characterized using morphological features and assimilation tests. Ten species were identified but, of these,Candida albicans andCandida parapsilosi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54476ea70375dcfaad53c3200288f26f
https://pubmed.ncbi.nlm.nih.gov/24221241
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7
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro
Autor: P. J. Masarachia, Steven P. Luckman, D. E. Hughes, Roslin Russell, A. A. Reszka, Gideon A. Rodan, J. M. Halasy, Michael J. Rogers, John E. Fisher, Gregg Wesolowski
Publikováno v: Proceedings of the National Academy of Sciences. 96:133-138
Nitrogen-containing bisphosphonates were shown to cause macrophage apoptosis by inhibiting enzymes in the biosynthetic pathway leading from mevalonate to cholesterol. This study suggests that, in osteoclasts, geranylgeranyl diphosphate, the substrate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a796e883d896cd436568db266dcfaf81
https://doi.org/10.1073/pnas.96.1.133
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8
Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras
Autor: R. Graham G. Russell, D. E. Hughes, Steven P. Luckman, Michael J. Rogers, F P Coxon
Publikováno v: Journal of Bone and Mineral Research. 13:581-589
Bisphosphonates are currently the most important class of antiresorptive drugs used for the treatment of metabolic bone diseases. Although the molecular targets of bisphosphonates have not been identified, these compounds inhibit bone resorption by m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d6fb266f6a5c96734fc3a49f190387
https://doi.org/10.1359/jbmr.1998.13.4.581
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10
Grazing of phytoplankton by copepods in eastern Antarctic coastal waters
Autor: D. E. Hughes, Kerrie M. Swadling, David A. Ritz, John A. E. Gibson, Peter D. Nichols
Publikováno v: Marine Biology. 128:39-48
Chlorophyll a, primary productivity and grazing by copepods on phytoplankton were measured in the upper water column during the summer of 1994/1995 at a coastal site near Davis Station, East Antarctica. Chlorophyll a was at a maximum in mid-December,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99e4d333282d87403f7ee5e1e092b958
https://doi.org/10.1007/s002270050066
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