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Isolation, sequencing, and disruption of the yeast CKA2 gene: casein kinase II is essential for viability in Saccharomyces cerevisiae

Autor: Ramesh Padmanabha, C. V. C. Glover, D. E. Hanna, J. L.-P. Chen-Wu

Publikováno v: Molecular and Cellular Biology. 10:4089-4099

Casein kinase II of Saccharomyces cerevisiae contains two distinct catalytic subunits, alpha and alpha', which are encoded by the CKA1 and CKA2 genes, respectively. Null mutations in the CKA1 gene do not confer a detectable phenotype (J. L.-P. Chen-W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4378cea2550799d82a2e39799c2e95fd
https://doi.org/10.1128/mcb.10.8.4089

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Isolation, Sequencing, and Disruption of the Yeast CKA2 Gene: Casein Kinase II Is Essential for Viability in Saccharomyces cerevisiae

Autor: R, Padmanabha, J L, Chen-Wu, D E, Hanna, C V, Glover

Publikováno v: Molecular and Cellular Biology. 10:4089-4099

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66357678a01cb539ec667635371e6912
https://doi.org/10.1128/mcb.10.8.4089-4099.1990

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Purification and characterization of casein kinase II (CKII) from delta cka1 delta cka2 Saccharomyces cerevisiae rescued by Drosophila CKII subunits. The free catalytic subunit of casein kinase II is not toxic in vivo

Autor: A P, Bidwai, D E, Hanna, C V, Glover

Publikováno v: The Journal of biological chemistry. 267(26)

Casein kinase II (CKII) is composed of a catalytic (alpha) and a regulatory (beta) subunit which unite to form an alpha 2 beta 2 holoenzyme. Saccharomyces cerevisiae CKII consists of two distinct catalytic (Sc alpha and Sc alpha') and regulatory (Sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::542dee0d445b886bd4c82ca4bc91397d
https://pubmed.ncbi.nlm.nih.gov/1527008

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Expression and purification of the alpha and beta subunits of Drosophila casein kinase II using a baculovirus vector

Autor: M J, Birnbaum, J, Wu, D R, O'Reilly, C A, Rivera-Marrero, D E, Hanna, L K, Miller, C V, Glover

Publikováno v: Protein expression and purification. 3(2)

Two recombinant baculoviruses that express the alpha and beta subunits of Drosophila melanogaster casein kinase II, respectively, have been constructed. The expressed proteins are similar to the authentic Drosophila subunits in size and are recognize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::455b4bff5687a1fcdd1c9a45b283bdf8
https://pubmed.ncbi.nlm.nih.gov/1422218

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A new conjugating agent for radioiodination of proteins: low in vivo deiodination of a radiolabeled antibody in a tumor model

Autor: P C, Srivastava, D J, Buchsbaum, J F, Allred, P G, Brubaker, D E, Hanna, J K, Spicker

Publikováno v: BioTechniques. 8(5)

A new radioiodinating agent, N-(p-[125I]iodophenyl)maleimide, has been synthesized for its potential utility in the radioiodination of monoclonal antibodies and other proteins. The efficiency of incorporation of 125I in the B72.3 antibody by iodine m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4073f0dc55c6ede73b3b740c9babde81
https://pubmed.ncbi.nlm.nih.gov/2357376

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Comparative binding and preclinical localization and therapy studies with radiolabeled human chimeric and murine 17-1A monoclonal antibodies

Autor: D J, Buchsbaum, P G, Brubaker, D E, Hanna, A A, Glatfelter, V H, Terry, D M, Guilbault, Z, Steplewski

Publikováno v: Cancer research. 50

Murine MoAb 17-1A is an IgG2a antibody reactive with a gastrointestinal cancer-associated cell surface antigen. Human-mouse chimeric 17-1A MoAbs were constructed in which the murine variable region of 17-1A was joined with human IgG1, IgG2, IgG3, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7f86ba18ae63560c5d092974639d46b
https://pubmed.ncbi.nlm.nih.gov/2297753

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Hyperventilation Syndrome

Autor: D E, Hanna, J B, Hodgens, W A, Daniel

Publikováno v: Pediatric Annals. 15:708-712

Hyperventilation is a common, though often unrecognized, disorder of adolescents. While relatively benign, the lack of recognition may lead to extensive, expensive, and unnecessary medical work-ups. The single most important factor in making the diag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade4d68c7865d06c1e6e1dc5f2584266
https://doi.org/10.3928/0090-4481-19861001-09

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Cytotoxic effects of anti-CD5 radioimmunotoxins on human tumors in vitro and in a nude mouse model

Autor: J M, Manske, D J, Buchsbaum, D E, Hanna, D A, Vallera

Publikováno v: Cancer research. 48(24 Pt 1)

An immunoconjugate, consisting of both toxin and radionuclide on the same antibody molecule, was synthesized by cross-linking the phytotoxin ricin to the T101 monoclonal antibody recognizing the CD5 cluster expressed on normal and malignant T-cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5622307fc6d1e33a246bc6d0e98c5ca4
https://pubmed.ncbi.nlm.nih.gov/2461252

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Antigenic modulation by anti-CD5 immunotoxins

Autor: J M, Manske, D J, Buchsbaum, S M, Azemove, D E, Hanna, D A, Vallera

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 136(12)

We evaluated the modulation of T101 immunotoxins (IT) and free T101 antibody from the surface of normal and leukemic cells to determine whether the presence of toxin on antibody affected antigenic modulation. Reagents were made by conjugating T101, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bdd14ec7049059cfd501218b5c70dd73
https://pubmed.ncbi.nlm.nih.gov/3086441

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