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Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies

Autor: J H, Antin, B E, Bierer, B R, Smith, J, Ferrara, E C, Guinan, C, Sieff, D E, Golan, R M, Macklis, N J, Tarbell, E, Lynch

Publikováno v: Blood. 78:2139-2149

Seventy-one patients with hematologic malignancies received bone marrow from a histocompatible sibling (n = 48) or a partially matched relative (n = 23) that had been depleted of CD5+ T cells with either an anti-CD5 mooclonal antibody (MoAb) plus com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8ff16973f9f5603ca9c012283b2cb7
https://doi.org/10.1182/blood.v78.8.2139.bloodjournal7882139

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Chloramphenicol-induced mitochondrial dysfunction is associated with decreased transferrin receptor expression and ferritin synthesis in K562 cells and is unrelated to IRE-IRP interactions

Autor: L M, Leiter, H S, Thatte, C, Okafor, P W, Marks, D E, Golan, K R, Bridges

Publikováno v: Journal of cellular physiology. 180(3)

Chloramphenicol is an antibiotic that consistently suppresses the bone marrow and induces sideroblastic anemia. It is also a rare cause of aplastic anemia. These toxicities are thought to be related to mitochondrial dysfunction, since chloramphenicol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::338fdbb7c4f66b9b58ac00a661572299
https://pubmed.ncbi.nlm.nih.gov/10430173

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Temporal synthesis of band 3 oligomers during terminal maturation of mouse erythroblasts. Dimers and tetramers exist in the membrane as preformed stable species

Autor: M, Hanspal, D E, Golan, Y, Smockova, S J, Yi, M R, Cho, S C, Liu, J, Palek

Publikováno v: Blood. 92(1)

Band 3, the anion transport protein of the erythrocyte membrane, exists in the membrane as a mixture of dimers (B3D) and tetramers (B3T). The dimers are not linked to the skeleton and constitute the free mobile band 3 fraction. The tetramers are link

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::72cfa84374b6711b9b41d9f94016fd72
https://pubmed.ncbi.nlm.nih.gov/9639533

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ATP depletion causes translational immobilization of cell surface transferrin receptors in K562 cells

Autor: H S, Thatte, K R, Bridges, D E, Golan

Publikováno v: Journal of cellular physiology. 166(2)

We have used quantitative fluorescence microscopy and fluorescence photobleaching recovery to examine the role of metabolic energy in the translational movement of transferrin receptors in the plasma membrane of K562 erythroleukemia cells. Cellular A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d14afe53ca8fbb8085004476369f4bf
https://pubmed.ncbi.nlm.nih.gov/8592005

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Adhesion of sickle neutrophils and erythrocytes to fibronectin

Autor: M R, Kasschau, G A, Barabino, K R, Bridges, D E, Golan

Publikováno v: Blood. 87(2)

The pathophysiology of vaso-occlusive crisis in sickle cell disease involves interactions among blood cells, plasma proteins, and vessel wall components. The initial goal of this work was to quantify the adhesion of sickle red blood cells (RBCs) to f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::193e3c1da2e54d376a221215b150457a
https://pubmed.ncbi.nlm.nih.gov/8555502

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Molecular basis of altered red blood cell membrane properties in Southeast Asian ovalocytosis: role of the mutant band 3 protein in band 3 oligomerization and retention by the membrane skeleton

Autor: S C, Liu, J, Palek, S J, Yi, P E, Nichols, L H, Derick, S S, Chiou, D, Amato, J D, Corbett, M R, Cho, D E, Golan

Publikováno v: Blood. 86(1)

Southeast Asian ovalocytosis (SAO) is an asymptomatic trait characterized by rigid, poorly deformable red cells that resist invasion by several strains of malaria parasites. The underlying molecular genetic defect involves simple heterozygous state f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22151541491dd9fb48c2ae685e1b0acd
https://pubmed.ncbi.nlm.nih.gov/7795244

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T-cell presentation of antigen requires cell-to-cell contact for proliferation and anergy induction. Differential MHC requirements for superantigen and autoantigen

Autor: J M, LaSalle, F, Toneguzzo, M, Saadeh, D E, Golan, R, Taber, D A, Hafler

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 151(2)

MHC class II+ human T-cell clones are able to simultaneously present and respond to peptide Ag and superantigen resulting in both proliferation and subsequent anergy. A major question remains as to whether a single T cell can present to itself or whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a9605913bbc4ea8bc26375edba95f0db
https://pubmed.ncbi.nlm.nih.gov/7687620

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Differential activation of phosphotyrosine protein phosphatase activity in a murine T cell hybridoma by monoclonal antibodies to CD45

Autor: S J, Goldman, S, Uniyal, L M, Ferguson, D E, Golan, S J, Burakoff, P A, Kiener

Publikováno v: The Journal of biological chemistry. 267(9)

The effect of two anti-CD45 (T200, LCA, Ly5) antibodies on the activation of the murine T-cell hybridoma 13.13 has been evaluated. These studies have been carried out in a system that did not require cross-linking or coclustering of antibodies. Activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::74ad6405a6e6917568c7e4b0f92cc126
https://pubmed.ncbi.nlm.nih.gov/1532579

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Transforming growth factor beta inhibits endomitosis in the Dami human megakaryocytic cell line

Autor: S M, Greenberg, C, Chandrasekhar, D E, Golan, R I, Handin

Publikováno v: Blood. 76(3)

Megakaryocyte development is a carefully controlled process that is at least partially regulated by cytokines. Previous investigations of megakaryocyte development have focused primarily on defining growth factors that induce or enhance differentiati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0813a8e3fe385037fd6c3731e0ed7af0
https://pubmed.ncbi.nlm.nih.gov/2378984

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