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CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy

Autor: J S, Bridgeman, K, Ladell, V E, Sheard, K, Miners, R E, Hawkins, D A, Price, D E, Gilham

Publikováno v: Clinical and Experimental Immunology

Chimeric antigen receptors (CARs) can mediate redirected lysis of tumour cells in a major histocompatibility complex (MHC)-independent manner, thereby enabling autologous adoptive T cell therapy for a variety of malignant neoplasms. Currently, most C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::989936b02d4e0da3048d68f7c6364420
https://pubmed.ncbi.nlm.nih.gov/24116999

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