Zobrazeno 1 - 10
of 29
pro vyhledávání: '"D E, Emmert"'
Autor:
Gary E. Zurenko, Betty H. Yagi, Douglas K Hutchinson, D E Emmert, David R. Graber, Jackson B. Hester, Stuart A. Garmon, Judith C. Hamel, Michael R Barbachyn, Ronda D. Schaadt, Michael J. Genin, Douglas Stapert, Joel Morris, David J. Anderson, Debra A. Allwine, R J Reischer, Charles W. Ford, Kevin C. Grega
Publikováno v:
Journal of Medicinal Chemistry. 43:953-970
A series of new nitrogen-carbon-linked (azolylphenyl)oxazolidinone antibacterial agents has been prepared in an effort to expand the spectrum of activity of this class of antibiotics to include Gram-negative organisms. Pyrrole, pyrazole, imidazole, t
Autor:
Charles W. Ford, Gary E. Zurenko, Hutchinson Douglas K, Betty H. Yagi, Janice M. Friis, D E Emmert, Michael J. Genin, Shobe Em, Jackson B. Hester, Stuart A. Garmon, Debra A. Allwine, Wade J. Adams, Ronda D. Schaadt, Judith C. Hamel, Douglas Stapert
Publikováno v:
Journal of Medicinal Chemistry. 41:5144-5147
Autor:
W. J. Howe, W. T. Lowther, J. O. Hui, W. G. Tarpley, D. E. Emmert, Chetana Rao, A G Tomasselli, John H. Kinner, V. S. Bradford, D. L. Alexander, Tomi K. Sawyer, B.M. Dunna, Robert A. Conradi, D. L. Decamp, Clark W. Smith, Allen W. Harrison, Charles S. Craik, James Michael Tustin, T. J. Mcquade, Robert L. Heinrikson, Y. Z. Zhang, Philip S. Burton, Jed F. Fisher, Roger A. Poorman, Joseph B. Moon, Jackson B. Hester, D J Staples, L. Liu, P. E. Scarborough, Maggiora Linda Louise
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:819-824
The structure-activity relationships and pharmacophore modeling aspects of a series of HIV PR inhibitors modified at the N- and/or C-terminus of the dipeptide isostere ChaΨ[CH(OH)CH2]Val (Cha, cyclohexylalanine) are reported. The HIV PR binding affi
Autor:
W. J. Howe, W. T. Lowther, A G Tomasselli, D. E. Emmert, D J Staples, Jackson B. Hester, W. G. Tarpley, J. O. Hui, Ben M. Dunn, John H. Kinner, Robert L. Heinrikson, Y. Z. Zhang, Tomi K. Sawyer, Charles S. Craik, D. L. Decamp, James Michael Tustin, T. J. Mcquade, D. L. Alexander, Allen W. Harrison, P. E. Scarborough, Robert A. Conradi, Jed F. Fisher, Roger A. Poorman, Philip S. Burton, Maggiora Linda Louise, V. S. Bradford, Joseph B. Moon, L. Liu, Clark W. Smith, Chetana Rao
Publikováno v:
ChemInform. 26
Autor:
J. K. Gibson, Jackson B. Hester, M. G. Cimini, B. E. West, Louis L. Skaletzky, P. K. Locker, J. K. Sykes, D. E. Emmert, S. C. Perricone
Publikováno v:
Journal of medicinal chemistry. 34(1)
N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamid e, (E)-2-butenedioate (2:1) salt (ibutilide fumarate, 2E), has been found to have Class III antiarrhythmic activity. In an in vitro rabbit heart tissue preparation designed to evaluat
Autor:
M. I. Dietrick, D. E. Emmert
Publikováno v:
Rubber Chemistry and Technology. 50:217-223
The analysis of variance of the elevated temperature tests conducted in this study showed that the experimental sample holder gave slightly higher values than tests run in an oven with the standard sample holder. However, this difference was less tha
Publikováno v:
Journal of Elastomers & Plastics. 9:77-93
Publikováno v:
Journal of Medicinal Chemistry. 32:1157-1163
A series of 1-(2-amino-1-phenylethyl)-6-phenyl-4H- [1,2,4]triazolo[4,3-a][1,4]benzodiazepines was prepared and evaluated for diuretic activity. These compounds have diuretic and natriuretic activity but no kaliuretic activity when evaluated by oral a
Publikováno v:
The Journal of Organic Chemistry. 36:3260-3266
Autor:
D E Emmert, D Lednicer
Publikováno v:
Journal of Medicinal Chemistry. 11:1258-1262