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Metabolism and disposition of the antifolate LY231514 in mice and dogs

Autor: J M, Woodland, C J, Barnett, D E, Dorman, J M, Gruber, C, Shih, L A, Spangle, T M, Wilson, W J, Ehlhardt

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 25(6)

The metabolism and disposition of LY231514 was studied in mice and dogs. LY231514 is a novel pyrrotopyrimidine-based multi-target antifolate (MTA) showing broad in vivo antitumor activity in mouse models and is currently in phase II human clinical tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::48d81a6e29dc392d58f7b420c4951a00
https://pubmed.ncbi.nlm.nih.gov/9193870

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Aqueous acidic degradation of the carbacephalosporin loracarbef

Autor: M J, Skibic, K W, Taylor, J L, Occolowitz, M W, Collins, J W, Paschal, L J, Lorenz, L A, Spangle, D E, Dorman, S W, Baertschi

Publikováno v: Journal of pharmaceutical sciences. 82(10)

The aqueous degradation of the carbacephalosporin loracarbef under moderately acidic conditions (pH range, 2.7-4.3) is described. Structures of a total of 10 compounds isolated by preparative reversed-phase HPLC have been proposed. Five of these 10 d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::13a36da2c389591d1e79d3e653750ee5
https://pubmed.ncbi.nlm.nih.gov/8254485

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Disposition of zatosetron, a serotonin (5-HT3) receptor antagonist, in humans

Autor: P M, Franz, E L, Mattiuz, B L, Hatcher, K A, DeSante, A P, Breau, J L, Occolowitz, D E, Dorman, C R, Schmid, M J, Goldberg, A, Rubin

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 21(2)

Zatosetron is being tested clinically as an antianxiety agent; it is a highly selective antagonist of the serotonin 5-HT3 receptor, with minimal agonist activity. The disposition of [14C]zatosetron was studied in five healthy men after a single oral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f8aa3c2219252f63efbad4c31cfab1a
https://pubmed.ncbi.nlm.nih.gov/8097693

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Capsular polymer of Haemophilus influenzae, type b. I. Structural characterization of the capsular polymer of strain Eagan

Autor: R S Baker, R M Crisel, D E Dorman

Publikováno v: Journal of Biological Chemistry. 250:4926-4930

The capsular type-specific antigen of Haemophilus influenzae, type b, has been reported to have a unit structure composed of D-ribose and phosphate. Recently, the presence of ribitol was found in preparations of type b capsular antigen. Our analytica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a055d396984149387b57e3a35c73789
https://doi.org/10.1016/s0021-9258(19)41257-x

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