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pro vyhledávání: '"D E, Clapham"'
Autor:
D E, Clapham
Publikováno v:
Heart and vessels.
The heart is composed of specialized cells ranging from sinoatrial nodal pacing cells with relatively few contractile elements to paced ventricular cells packed with contractile muscle protein. Arising in the sinoatrial node and transmitted throughou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14382c7177799db7e2e95cabd85d2ad6
https://pubmed.ncbi.nlm.nih.gov/9476572
https://pubmed.ncbi.nlm.nih.gov/9476572
Autor:
D E, Clapham, E J, Neer
Publikováno v:
Annual review of pharmacology and toxicology. 37
Guanine nucleotide binding (G) proteins relay extracellular signals encoded in light, small molecules, peptides, and proteins to activate or inhibit intracellular enzymes and ion channels. The larger G proteins, made up of G alpha beta gamma heterotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f65da3512a1a48553ef76971a3675c13
https://pubmed.ncbi.nlm.nih.gov/9131251
https://pubmed.ncbi.nlm.nih.gov/9131251
Autor:
D E, Clapham
Publikováno v:
Current biology : CB. 6(7)
G-protein-coupled receptors that modulate Ca2+ channels that mediate synaptic transmission seem to use the G beta gamma, and not the G alpha, subunits of the trimeric G protein to slow and inhibit the Ca2+ currents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f2abfd47b83bc20400f5a809c6769d9b
https://pubmed.ncbi.nlm.nih.gov/8835861
https://pubmed.ncbi.nlm.nih.gov/8835861
Publikováno v:
Science (New York, N.Y.). 272(5270)
Homozygous weaver mice are profoundly ataxic because of the loss of granule cell neurons during cerebellar development. This granule cell loss appears to be caused by a genetic defect in the pore region (Gly156--Ser) of the heterotrimeric guanine nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e334aa60981f25fba9e6faa243876df7
https://pubmed.ncbi.nlm.nih.gov/8658170
https://pubmed.ncbi.nlm.nih.gov/8658170
Publikováno v:
The Journal of biological chemistry. 270(49)
The cardiac G protein-gated K+ channel, IKACh, is activated by application of purified and recombinant beta and gamma subunits (G beta gamma) of heterotrimeric G proteins to excised inside-out patches from atrial membranes (Logothetis, D. E., Kurachi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::52efdb622df0cf8321a9e0889853de0f
https://pubmed.ncbi.nlm.nih.gov/7493925
https://pubmed.ncbi.nlm.nih.gov/7493925
Autor:
D E, Clapham, J, Sneyd
Publikováno v:
Advances in second messenger and phosphoprotein research. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::76697594408ec8bd54c28685d55a9145
https://pubmed.ncbi.nlm.nih.gov/7695987
https://pubmed.ncbi.nlm.nih.gov/7695987
Autor:
S, Girard, D E, Clapham
Publikováno v:
Methods in cell biology. 40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8309bb7d5e4c860c16edd79809f13cb0
https://pubmed.ncbi.nlm.nih.gov/8201979
https://pubmed.ncbi.nlm.nih.gov/8201979
Autor:
D E, Clapham, E J, Neer
Publikováno v:
Nature. 365(6445)
When a membrane-bound receptor acts on a G protein, the GTP-binding or G alpha subunit dissociates from the G beta gamma dimer. Until recently, the G alpha subunit alone was thought to act on the enzymes and ion channels controlled by these proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::80787b818bdf86001a2b5949e958bd72
https://pubmed.ncbi.nlm.nih.gov/8413584
https://pubmed.ncbi.nlm.nih.gov/8413584
Publikováno v:
Journal of Investigative Medicine. 53:S292.4-S292
Background The transient receptor potential channel M7 (TRPM7) is a ubiquitously expressed divalent cation selective ion channel with the exceptional feature of also being a serine/threonine kinase. TRPM7 is part of the TRP ion channel superfamily im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37398ca8096c113f6843e7b2bc56ec2c
https://doi.org/10.2310/6650.2005.00006.224
https://doi.org/10.2310/6650.2005.00006.224