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pro vyhledávání: '"D Dykstra"'
Autor:
Michael Wleklinski, Paige M. Carpenter, Kevin D. Dykstra, Anthony Donofrio, Timothy Nowak, Shane W. Krska, Ronald D. Ferguson
Publikováno v:
SLAS Technology, Vol 29, Iss 2, Pp 100126- (2024)
High-throughput experimentation (HTE) has become more widely utilized in drug discovery for rapid reaction optimization and generation of large synthetic compound arrays. While this has accelerated medicinal chemistry design, make, test (DMT) iterati
Externí odkaz:
https://doaj.org/article/551f9a876fc040d694b69bd9e46488ad
Autor:
Lamar, Howard R.
Publikováno v:
The American Historical Review, 1969 Feb 01. 74(3), 1095-1097.
Externí odkaz:
https://www.jstor.org/stable/1873283
Akademický článek
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Publikováno v:
In Archives of Physical Medicine and Rehabilitation 2004 85(9):e37-e37
Publikováno v:
In Archives of Physical Medicine and Rehabilitation 2004 85(9):e13-e14
Autor:
Alexei V. Buevich, Ming Wang, Shane W. Krska, Milana Maletic, Min Liu, Eric Streckfuss, Younong Yu, Robert W. Myers, Jian Liu, Petr Vachal, Kevin D. Dykstra, Joseph A. Kozlowski
Publikováno v:
ACS Med Chem Lett
[Image: see text] An integrated workflow has been established that enables the synthesis, purification, and subsequent biological testing of compound libraries on a microgram scale. This approach utilizes mass directed preparative HPLC in conjunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e258e2554547baddad36c5f86e745eda
https://doi.org/10.1021/acsmedchemlett.0c00596
https://doi.org/10.1021/acsmedchemlett.0c00596
Autor:
Dong-Ming Shen, Michael Wolff, Shirly Pinto, Deodial Guiadeen, Bindhu V. Karanam, James M. Balkovec, Arto D. Krikorian, Shuwen He, Maria Madeira, Donald M. Sperbeck, Andreas Verras, Judyann Wiltsie, Jian Liu, Jackie Shang, Tim Cernak, Beth Ann Murphy, Qingmei Hong, Christine C. Chung, Ravi P. Nargund, Kevin D. Dykstra, Judith N. Gorski, Robert J. DeVita, Sharon Tong, Tianying Jian, Lisa M. Sonatore, Jeffrey T. Kuethe, Jianying Xiao, Jinqi Liu, Zhong Lai, Zhicai Wu, Mikhail Reibarkh, Ginger X. Yang, Yang Yu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1182-1186
Previously disclosed benzimidazole-based DGAT1 inhibitors containing a cyclohexane carboxylic acid moiety suffer from isomerization at the alpha position of the carboxylic acid group, generating active metabolites which exhibit DGAT1 inhibition compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d804bc7e0890d2b1abe6ee34b194779
https://doi.org/10.1016/j.bmcl.2019.03.025
https://doi.org/10.1016/j.bmcl.2019.03.025
Autor:
Dennis D. Dykstra
Publikováno v:
Pain Management Case Reports. :39-42
Recently, the use of botulinum toxin type A (BoNT-A) has been reported to help with neuropathic pain reduction in numerous conditions, including painful chronic scar formation. The mechanism by which BoNT-A inhibits pain is unclear, but it appears to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dec64a57ec4e89125614c55a38eab5a6
https://doi.org/10.36076/pmcr.2017/1/39
https://doi.org/10.36076/pmcr.2017/1/39
Autor:
Jinchu Liu, Maarten Hoek, Qiang Tan, Andreas Verras, Don Gauthier, Tim Cernak, Kevin D. Dykstra, Anthony Ogawa, Yun-Fang Yang, Shane W. Krska, Robert J. DeVita, Dong-Ming Shen, Beata Zamlynny, Thomas Bateman, Ravi Kurukulasuriya, Yili Chen, Lisa DiMichelle, Kun Liu, Alejandro Crespo, Petr Vachal, Jeffrey Madwed, Kendall N. Houk
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(14)
The derivatization of pharmaceuticals is a core activity in the discovery and development of new medicines. Late-stage functionalization via modern C H functionalization chemistry has emerged as a powerful technique with which to diversify advanced p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9397cb2536275f111ddd3b473f58897d
https://pubmed.ncbi.nlm.nih.gov/31104995
https://pubmed.ncbi.nlm.nih.gov/31104995