Výsledky vyhledávání - "D D Williams"

A phase I trial of ispinesib, a kinesin spindle protein inhibitor, with docetaxel in patients with advanced solid tumours

Autor: S J Kathman, J.S. de Bono, Mohammed M. Dar, Carolyn J. Bowen, Mark R. Middleton, D D Williams, Miranda Payne, Sarah P. Blagden, L. R. Molife, J. P. Hodge, Andrew Protheroe, L S Vasist, Alison Reid, A Seebaran

Publikováno v: British Journal of Cancer

The aim of this study is to define the maximum tolerated dose (MTD), safety, pharmacokinetics (PKs) and efficacy of ispinesib (SB-715992) in combination with docetaxel. Patients with advanced solid tumours were treated with ispinesib (6-12 mg m(-2))

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595564b236ce6525445003d1cd45e7b3
https://doi.org/10.1038/sj.bjc.6604264

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In Vitro Attachment of Salmonella typhimurium to Chicken Cecal Mucus: Effect of Cations and Pretreatment with Lactobacillus spp. Isolated from the Intestinal Tracts of Chickens

Autor: D. D. Williams, S. E. Craven

Publikováno v: Journal of Food Protection. 61:265-271

The attachment of radiolabeled Salmonella typhimurium 333/O cells to immobilized cecal mucus from specific-pathogen-free leghorn chickens was determined in the presence of D-mannose. The attachment of S. typhimurium was inhibited by the chelating age

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c969cffaf6cd606fe7af0f9bcf8a721
https://doi.org/10.4315/0362-028x-61.3.265

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Response of dissolved organic carbon in a shallow groundwater ecosystem to a simulated global warming experiment

Autor: D. D. Williams, K. P. Wilson

Publikováno v: Geo-Environment and Landscape Evolution II: Monitoring, Simulation, Management and Remediation.

Dissolved organic carbon (DOC) in marine and freshwater ecosystems represents an immense reservoir of organic matter with varied and significant ecological value. Global warming poses a significant threat in that it has the capacity to alter the conc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c314774b00becbcb16fae16b3d66cda
https://doi.org/10.2495/geo060171

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Inhibition of Salmonella typhimurium attachment to chicken cecal mucus by intestinal isolates of Enterobacteriaceae and lactobacilli

Autor: S E, Craven, D D, Williams

Publikováno v: Avian diseases. 41(3)

The ability of selected strains of Enterobacteriaceae or lactobacilli isolated from the intestines of adult chickens to inhibit in vitro attachment of Salmonella typhimurium 3333/O to cecal mucus in the presence or absence of D-mannose was determined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ecd82e83961c0041725126c06e4da0c9
https://pubmed.ncbi.nlm.nih.gov/9356699

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Health care of women in prison: an overview

Autor: S, Tucker-Allen, D D, Williams, S M, Wisneski

Publikováno v: The ABNF journal : official journal of the Association of Black Nursing Faculty in Higher Education, Inc. 5(2)

The authors review what has been written in the literature on health care of women in prison as preparation for a research study on perceived health care needs of women in prison. Preliminary instruments developed by the authors are included.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::252b73786521cc6895fd4c2b0cbcf23a
https://pubmed.ncbi.nlm.nih.gov/8161814

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A phase 0 exploratory study to assess the pharmacodynamic effects of single intratumoral dose of a novel bispecific targeting/immune-activating agent on the melanoma tumor microenvironment

Autor: Anne Chew, Lynn M. Schuchter, Elizabeth Veloso, Namir J. Hassan, Brian J. Czerniecki, Michael Kalos, Gerald P. Linette, Bent K. Jakobsen, D. D. Williams, Ravi K. Amaravadi, Giorgos C. Karakousis, Carl H. June, Leslie A. Fecher, Y. McGrath

Publikováno v: Journal of Clinical Oncology. 29:TPS160-TPS160

TPS160 Background: IMCgp100 is a novel biologic comprising a soluble T cell receptor (TCR) fused to an antibody fragment (scFv) being developed for the treatment of metastatic melanoma. The TCR component binds to the melanoma associated antigen (Ag)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53d7f7d2ad22b9cd560791c104bb3d6a
https://doi.org/10.1200/jco.2011.29.15_suppl.tps160

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Phase I study to determine tolerability and pharmacokinetics (PK) of SB-743921, a novel kinesin spindle protein (KSP) inhibitor

Autor: D. D. Williams, Ramesh K. Ramanathan, George Wilding, Sakkaraiappan Ramalingam, J. L. Heideman, Mohammed M. Dar, Kyle D. Holen, Chandra P. Belani, J. P. Hodge, Carolyn J. Bowen

Publikováno v: Journal of Clinical Oncology. 24:2000-2000

2000 Background: SB-743921, a potent and selective inhibitor of KSP (Ki =100 pM; >40,000-fold selectivity vs other kinesins), causes mitotic arrest, potent inhibition of tumor cell proliferation, and demonstrates activity in a broad range of human tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88923f1d99a799ecb3d18988705eb118
https://doi.org/10.1200/jco.2006.24.18_suppl.2000

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