Zobrazeno 1 - 10
of 36
pro vyhledávání: '"D D Eardley"'
Autor:
P Hunt, D D Eardley
Publikováno v:
The Journal of Immunology. 136:3994-3999
This paper describes conditions wherein the serum peptides insulin and IGF1, which are typically associated with growth-promoting functions, can suppress in vitro immune responses. IL 2-induced proliferation of lymphocytes as well as in vitro antibod
Autor:
G N Gaulton, D D Eardley
Publikováno v:
The Journal of Immunology. 136:2470-2477
The addition of IL 2 to Con A-activated splenic T cells induced the rapid and time-dependent phosphorylation of membrane proteins with m.w. of 115,000 to 105,000, 90,000, and 66,000, and to a lesser extent 55,000 to 58,000, 40,000, and 34,000. Immuno
Publikováno v:
The Journal of Immunology. 124:1199-1202
Lymphotoxin is produced by T cells sensitized to antigen upon re-exposure in vitro. It is also elicited by mitogen treatment. Its production has been correlated with delayed-type hypersensitivity and it may be a mediator of that phenomenon. We have e
Publikováno v:
The Journal of Immunology. 131:2154-2157
Ly-2+ effectors of T cell-mediated suppression require inducing signals from antigen and a helper cell bearing the Ly-1+:Qa1+ surface phenotype. In this report, we have further examined the helper cell requirements for suppressor cell induction of an
Publikováno v:
The Journal of Immunology. 134:3089-3093
Mucoid exopolysaccharide isolated from Pseudomonas aeruginosa obtained from colonized cystic fibrosis patients was found to be a potent mitogen for mouse lymphocytes. The responding lymphocyte was a B cell, and we found no evidence that T cell could
Autor:
D D Eardley
Publikováno v:
The Journal of Immunology. 130:2209-2213
Clones of sheep erythrocyte-(SRBC) specific helper T cells with the surface phenotype Thy-1+, Ly-1+, Ly-2- have been derived that grow in vitro in the absence of exogenous antigen or added growth factors. The IL 2-independent clone, 101.6 has been sh
Publikováno v:
The Journal of Experimental Medicine
Spleen cells educated in vitro with sheep red blood cells (SRBC) suppressed the plaque-forming cell response of Mishell-Dutton assay cultures challenged with optimal doses of SRBC. Changing conditions in the assay cultures changed the effect educated
Publikováno v:
The Journal of Immunology. 131:2576-2579
Splenocytes from DBA/2 mice inoculated 3 wk earlier with syngeneic P815 mastocytoma tumor cells produce increased numbers of antibody plaque-forming cells (PFC) when stimulated with either sheep red blood cells (SRBC) or phosphorylcholine (PC) on Str
Publikováno v:
The Journal of Immunology. 122:1663-1665
Lyl T cells are able to induce B cells to make antibody and also to induce a resting Ly123 T cell set to exert potent feedback suppression. Which of these two pathways Lyl T cells take can be influenced by the mode of immunization. In particular, in
Publikováno v:
Diabetologia. 28(10)
The efficacy of the diabetogenic drags streptozotocin and alloxan were evaluated as models for the study of immune defects associated with diabetes. Streptozotocin- or alloxan-treated mice, with a stable hyperglycaemia of 25–33 mmol/l plasma glucos