Zobrazeno 1 - 10
of 50
pro vyhledávání: '"D D Chaplin"'
Autor:
Y. Ueda, P. N. Boyaka, Zuzana Jiraskova Zakostelska, K. Inagaki-Ohara, C. E. Martin, S. Hansen, K. Fujihashi, A. Lo, I. Yang, E. Umemoto, N. Yoshida, C. D. Surh, D. Kim, Y. Iwasaki, K. S. Schluns, D. D. Chaplin, R. Kobayashi, S. Takaki, K. Lee, M. Iseki, J. Tomala, S. Kim, H. Kayama, Y. Saito, M. Kovar, R. S. Gilbert, Lucia Hrncirova, M. Hou, M. Miyasaka, T. Iwase, U. Gehrmann, A. Yoshimura, Y. Lai, H. Katayama, D. A. Peterson, Y. Iwakura, Tomas Hrncir, K. Takatsu, N. Almqvist, S. Lindgren, D. Papazian, Y. Minokoshi, G. Matsuzaki, M. Yamasaki, R. Hamamichi, T. Vorup-Jensen, S. Kato, Y. Jang, T. Chhoden, N. Marsteller, Helena Tlaskalova-Hogenova, N. Liao, K. Takeda, K. Skjoedt, Klara Klimesova, Y. Fukuyama, M. Fujimoto, Miloslav Kverka, N. Verjan Garcia, T. Matozaki, K. Lund, S. Huang, M. Murakami, H. Yang-Yen, P. A. Würtzen, L. J. Ma, C. Nielsen, E. Telemo, M. Arge, K. Komiyama, M. Jang, J. Y. Lee
Publikováno v:
International Immunology. 22:iii133-iii135
Publikováno v:
The Journal of Immunology. 153:143-152
To define the cis-acting elements that regulate LPS-stimulated IL-1 beta gene transcription, we analyzed the murine IL-1 beta gene by digestion with DNase I. At least two hypersensitive sites were located between 2200 and 2600 bp upstream of the tran
Autor:
L A Demmer, D D Chaplin
Publikováno v:
The Journal of Immunology. 150:5371-5378
Gene transfer using yeast artificial chromosome (YAC) clones provides an opportunity to study the expression of several linked genes within an environment more closely approximating their normal chromosomal context. A YAC clone spanning 330 kb of the
Autor:
A D Howard, M J Kostura, N Thornberry, G J Ding, G Limjuco, J Weidner, J P Salley, K A Hogquist, D D Chaplin, R A Mumford
Publikováno v:
The Journal of Immunology. 147:2964-2969
IL-1 converting enzyme (ICE) specifically cleaves the human IL-1 beta precursor at two sequence-related sites: Asp27-Gly28 (site 1) and Asp116-Ala117 (site 2). Cleavage at Asp116-Ala117 results in the generation of mature, biologically active IL-1 be
Publikováno v:
The Journal of Immunology. 146:1534-1540
The role of murine IL-1 beta in vitro and in vivo has not been defined. We describe here the production of neutralizing and immunoprecipitating mAb and polyclonal antibodies specific for murine IL-1 beta and their application to a characterization of
Autor:
G C Webb, D D Chaplin
Publikováno v:
The Journal of Immunology. 145:1278-1285
Variability in the structure of the human tumor necrosis factor (TNF-alpha) or lymphotoxin (TNF-beta) genes may contribute to the functional polymorphism of the HLA gene complex. We have characterized an allelic restriction fragment length polymorphi
Autor:
I, Hussain, D, Randolph, S L, Brody, S K, Song, A, Hsu, A M, Kahn, D D, Chaplin, D L, Hamilos
Publikováno v:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 31(7)
To further elucidate mechanisms of human allergic rhinosinusitis, we studied the induction, distribution and modulation of allergen-induced upper airway inflammation in a BALB/c mouse model.Allergic inflammation induced with ovalbumin (OVA) by intrap
Autor:
K. Yasuda, K. Matsuya, T. Takihara, A. Ishizaka, K. Fukunaga, Y. Kawano, M. Egawa, H. Shitara, K. Tomomatsu, F. Jonsson, R. Takamiya, F. Hosokawa, T. Satoh, M. Nakahira, K. Niimi, D. A. Mancardi, K. Mukai, H. Ogura, S. Tanaka, T. Nabe, K. Ishiwata, N. Mizutani, P. Bruhns, B. Iannascoli, S. Nakae, T. Morishita, T. Oguma, M. Kubo, Y. Minegishi, D. D. Chaplin, C. Taya, N. Kamiishi, K. Oboki, M. Kodama, T. Yoshimoto, T. Wada, K. Sayama, T. Kambayashi, K. Obata, S. Yoshino, H. Yokozeki, J. Miyata, H. Tanaka, H. Karasuyama, K. Nakanishi, M. Sawaguchi, K. Tanaka, M. Fujii, N. Ohmari, K. Asano, N. Watanabe, S. Yoshikawa, K. Saeki, M. Daeron
Publikováno v:
International Immunology. 22:ii130-ii131
Publikováno v:
Blood. 94(3)
Jak3 is a cytoplasmic tyrosine kinase that associates with the common chain of the interleukin-2 (IL-2) receptor and is involved in the function of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. Mice deficient in Jak3 have few T and B cells, an
Autor:
D A, Giegel, D D, Chaplin
Publikováno v:
Agents and actions. Supplements. 49
The first morning session of the Eighth International Conference of the Inflammation Research Association was titled 'Targets in Cytokine Activation'. It encompassed four areas of research that may be considered as either current or future targets. P