Zobrazeno 1 - 10
of 722
pro vyhledávání: '"D D, Wood"'
Autor:
Mario A. Moscarello, Fabrizio G. Mastronardi, Li Zhang, Reinout Raijmakers, Cameron Ackerley, Ben van den Brand, D. D. Wood
Publikováno v:
Laboratory Investigation. 88:354-364
An understanding of the structure and composition of the myelin sheath is essential to understand the pathogenesis of demyelinating diseases such as multiple sclerosis (MS). The presence of citrulline in myelin proteins in particular myelin basic pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8511e8bfc244f84df4b98241373bf7
https://doi.org/10.1038/labinvest.3700748
https://doi.org/10.1038/labinvest.3700748
Autor:
Mario A. Moscarello, Ramin Zand, Jeongkwon Kim, David M. Lubman, D. D. Wood, Fabrizio G. Mastronardi
Publikováno v:
Molecular & Cellular Proteomics. 2:453-462
Myelin basic protein (MBP) represents a candidate autoantigen in multiple sclerosis (MS). We isolated MBP from normal and MS human white matter and purified six components (charge isomers) to compare the post-translational modifications on each. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62beba10d033aad91b92f142e1027e54
https://doi.org/10.1074/mcp.m200050-mcp200
https://doi.org/10.1074/mcp.m200050-mcp200
Publikováno v:
Journal of Neurochemistry. 81:335-343
In earlier studies we demonstrated that an increase in the relative amounts of citrullinated myelin basic protein (MBP) was found in multiple sclerosis (Moscarello et al. 1994). To determine the temporal relationship between the citrullinated MBP and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d444d590da29c58403575e9543b0248b
https://doi.org/10.1046/j.1471-4159.2002.00834.x
https://doi.org/10.1046/j.1471-4159.2002.00834.x
Autor:
Mario A. Moscarello, Samuel K. Ludwin, B Mak, Fabrizio G. Mastronardi, T A Nguyen, D. D. Wood
Publikováno v:
Multiple Sclerosis Journal. 8:130-138
Treatment with paclitaxel by four intraperitoneal injections (20 mg/kg) 1 week apart attenuated clinical signs in a spontaneously demyelinating model, if given with onset of clinical signs. If given at 2 months of age (1 month prior to clinical signs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb35c368ab0466c38f7011615c032332
https://doi.org/10.1191/1352458502ms776oa
https://doi.org/10.1191/1352458502ms776oa
Publikováno v:
Annals of Neurology. 40:18-24
We have studied a case of acute, fulminating multiple sclerosis (MS) (Marburg type) at the pathological and biochemical levels. Postmortem examination of the brain revealed extensive areas of gross rarefaction in the hemispheric white matter. Histolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d2d8de392daffa80119bcad7e37a08
https://doi.org/10.1002/ana.410400106
https://doi.org/10.1002/ana.410400106
Publikováno v:
Journal of Clinical Investigation. 94:146-154
The etiology of multiple sclerosis (MS) is considered to involve genetic, environmental, infective, and immunological factors which affect the integrity of a normally assembled myelin sheath, either directly or indirectly resulting in demyelination.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e61f4d26ce2bd55f1fb8436cb697b0
https://doi.org/10.1172/jci117300
https://doi.org/10.1172/jci117300
Publikováno v:
Journal of Neurochemistry. 55:1697-1702
Myelin basic protein (MBP) from shark (Chondricthyes) consists of a simpler mixture of charge isomers than human MBP. About two-thirds of the total amount applied to a CM-52 cellulose cation-exchange column was recovered in the unbound fraction of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9103f0bc8e04403d21264d7511508c
https://doi.org/10.1111/j.1471-4159.1990.tb04958.x
https://doi.org/10.1111/j.1471-4159.1990.tb04958.x
Autor:
Winer S, Mastronardi Fg, Dosch Hm, Carole L. Galligan, Tsui H, Mario A. Moscarello, Eleanor N. Fish, D. D. Wood, Selvanantham T
Publikováno v:
Multiple sclerosis (Houndmills, Basingstoke, England). 13(5)
Progressive demyelination in multiple sclerosis (MS) reflects the negative balance between myelin damage and repair due to physical and molecular barriers, such as astrocytic glial scars, between oligodendrocytes and target neurons. In this paper, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a6d3589731cddcd81b8369ac843e07
https://pubmed.ncbi.nlm.nih.gov/17548438
https://pubmed.ncbi.nlm.nih.gov/17548438
Publikováno v:
Molecularcellular proteomics : MCP. 2(7)
Myelin basic protein (MBP) represents a candidate autoantigen in multiple sclerosis (MS). We isolated MBP from normal and MS human white matter and purified six components (charge isomers) to compare the post-translational modifications on each. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50a9b4457c0f9e7917a3fdbf4a489508
https://pubmed.ncbi.nlm.nih.gov/12832457
https://pubmed.ncbi.nlm.nih.gov/12832457
Publikováno v:
Journal of neurochemistry. 81(2)
In earlier studies we demonstrated that an increase in the relative amounts of citrullinated myelin basic protein (MBP) was found in multiple sclerosis (Moscarello et al. 1994). To determine the temporal relationship between the citrullinated MBP and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83607f8ed8904d55a409fd173450498a
https://pubmed.ncbi.nlm.nih.gov/12064481
https://pubmed.ncbi.nlm.nih.gov/12064481