Výsledky vyhledávání - "D D, Metcalfe"

Glucocorticoids decrease tissue mast cell number by reducing the production of the c-kit ligand, stem cell factor, by resident cells: in vitro and in vivo evidence in murine systems

Autor: D D Metcalfe, S Finotto, Y A Mekori

Publikováno v: Journal of Clinical Investigation. 99:1721-1728

The local delivery of glucocorticoids to tissues significantly decreases mast cell number. This pharmacologic effect of glucocorticoids is believed to be one of the mechanisms by which glucocorticoids regulate allergic inflammation. To determine the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc65e3f5e18c23b5b2683ac76a63963
https://doi.org/10.1172/jci119336

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Aggregation of low affinity IgG receptors induces mast cell adherence to fibronectin: requirement for the common FcR gamma-chain

Autor: J Dastych, M C Hardison, D D Metcalfe

Publikováno v: The Journal of Immunology. 158:1803-1809

Mast cells have been reported to increase at sites of immune complex-induced inflammation where these cells appear to potentiate the inflammatory response. The mechanism by which mast cells accumulate at these sites is unknown. One possibility is tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fba4fa0195d65974d8873adaa349ab3c
https://doi.org/10.4049/jimmunol.158.4.1803

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Systemic mastocytosis: CT and US features of abdominal manifestations

Autor: D D Metcalfe, J M Mican, A S Worobec, Nilo A. Avila, Alexander Ling

Publikováno v: Radiology. 202:367-372

To study the imaging findings in patients with systemic mastocytosis and to correlate the findings with the severity of disease on the basis of an established classification system. Pathologic findings, when available, were correlated with imaging fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96760129bd541bb16fcb27d8db190e8d
https://doi.org/10.1148/radiology.202.2.9015059

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Lymphotactin gene expression in mast cells following Fc(epsilon) receptor I aggregation: modulation by TGF-beta, IL-4, dexamethasone, and cyclosporin A

Autor: V Rumsaeng, H Vliagoftis, C K Oh, D D Metcalfe

Publikováno v: The Journal of Immunology. 158:1353-1360

Recruitment of lymphocytes is a prominent feature of allergic inflammation. However, the mechanisms by which lymphocytes are attracted to such sites are not understood. Recently, cDNAs encoding a lymphocyte-specific chemokine, lymphotactin (Ltn), wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7bc258841022bbe7e5516eec4ce79d3
https://doi.org/10.4049/jimmunol.158.3.1353

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Transforming growth factor-beta prevents stem cell factor-mediated rescue of mast cells from apoptosis after IL-3 deprivation

Autor: Y A Mekori, D D Metcalfe

Publikováno v: The Journal of Immunology. 153:2194-2203

IL-3-dependent mast cells undergo apoptosis upon removal of IL-3, an event that is prevented by the addition of stem cell factor (SCF) acting through its receptor c-kit, suggesting that SCF provides a mechanism to allow mast cells to survive and to d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::582b8ecad5c327c7b40e9c094bbb7631
https://doi.org/10.4049/jimmunol.153.5.2194

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Stem cell factor induces mast cell adhesion to fibronectin

Autor: J Dastych, D D Metcalfe

Publikováno v: The Journal of Immunology. 152:213-219

Stem cell factor (SCF) or c-kit ligand is a growth factor cytokine produced by stromal cells that is known to influence mast cell proliferation and differentiation. We hypothesized that SCF may also influence the adhesion of mast cells to connective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec7f2d006d2cc4ad0a058da25cb1187f
https://doi.org/10.4049/jimmunol.152.1.213

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Bone marrow stromal cells inhibit mast cell function via a COX2-dependent mechanism

Autor: J M, Brown, K, Nemeth, N M, Kushnir-Sukhov, D D, Metcalfe, E, Mezey

Publikováno v: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 41(4)

Mast cells (MCs) have a central role in the induction of allergic inflammation, such as seen in asthma, and contribute to the severity of certain autoimmune diseases, such as rheumatoid arthritis. The MC thus represents an important inflammatory cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ded96479c715cc253871848bf6569dc3
https://pubmed.ncbi.nlm.nih.gov/21255158

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Identification of tropomyosin as the major shrimp allergen and characterization of its IgE-binding epitopes

Autor: K N Shanti, B M Martin, S Nagpal, D D Metcalfe, P V Rao

Publikováno v: The Journal of Immunology. 151:5354-5363

The major heat-stable shrimp allergen (designated as Sa-II), capable of provoking IgE-mediated immediate type hypersensitivity reactions after the ingestion of cooked shrimp, has been shown to be a 34-kDa heat-stable protein containing 300 amino acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::058e98ecc960d1d8bc98fb4ac223f86f
https://doi.org/10.4049/jimmunol.151.10.5354

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The effects of stem cell factor on the ultrastructure of Fc epsilon RI+ cells developing in IL-3-dependent murine bone marrow-derived cell cultures

Autor: M Rottem, J P Goff, J P Albert, D D Metcalfe

Publikováno v: The Journal of Immunology. 151:4950-4963

Stem cell factor (SCF) is known to alter the proteoglycans, proteases, and cytokines synthesized by mast cells and to activate basophils. To determine whether SCF could also effect the ultrastructural characteristics of basophils and mast cells, we e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb24c3269e371d9020db7a065291f683
https://doi.org/10.4049/jimmunol.151.9.4950

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