Mutations affecting hepadnavirus plus-strand DNA synthesis dissociate primer cleavage from translocation and reveal the origin of linear viral DNA

Autor: Silvija I. Staprans, Don Ganem, D D Loeb

Publikováno v: Journal of Virology. 65:1255-1262

Hepadnaviruses replicate their circular DNA genomes via reverse transcription of an RNA intermediate. The initial product of reverse transcription, minus-strand DNA, contains two copies of a short direct repeat (DR) sequence, termed DR1 and DR2. Plus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f052a7fd4d54d6885ac8e7d973db470
https://doi.org/10.1128/jvi.65.3.1255-1262.1991

Analysis of retroviral protease cleavage sites reveals two types of cleavage sites and the structural requirements of the P1 amino acid

Autor: S C, Pettit, J, Simsic, D D, Loeb, L, Everitt, C A, Hutchison, R, Swanstrom

Publikováno v: The Journal of biological chemistry. 266(22)

Retroviruses encode a protease which cleaves the viral Gag and Gag/Pol protein precursors into mature products. To understand the target sequence specificity of the viral protease, the amino acid sequences from 46 known processing sites from 10 diver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f1471a55098597258998896c4975a038
https://pubmed.ncbi.nlm.nih.gov/1860860

Analysis of temperature-sensitive mutants of the HIV-1 protease

Autor: M, Manchester, D D, Loeb, L, Everitt, M, Moody, C A, Hutchison, R, Swanstrom

Publikováno v: Advances in experimental medicine and biology. 306

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ab56ed2808a3d0ec171295906fc1286
https://pubmed.ncbi.nlm.nih.gov/1812748

Mutational Analysis of the HIV-1 Protease: Importance for Function of Sequences within and Flanking the Protease Domain

Autor: R. Swanstrom, D. D. Loeb, William G. Farmerie, Lorraine Everitt, C. A. Hutchison

Publikováno v: Proteases of Retroviruses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc033db6b924891d8864b642ceb9c5f9
https://doi.org/10.1515/9783110862782-014

Clinician and staff perspectives on potential disparities introduced by the rapid implementation of telehealth services during COVID-19: a mixed-methods analysis.

Autor: Phimphasone-Brady P; Department of Psychiatry, University of Colorado, Aurora, CO, USA., Chiao J; Division of General Internal Medicine, Department of Medicine, University of Colorado, Aurora, CO, USA., Karamsetti L; Department of Psychiatry, University of Colorado, Aurora, CO, USA., Sieja A; Division of General Internal Medicine, Department of Medicine, University of Colorado, Aurora, CO, USA., Johnson R; Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, USA., Macke L; Division of General Internal Medicine, Department of Medicine, University of Colorado, Aurora, CO, USA., Lum H; Division of Geriatric Medicine, Department of Medicine, University of Colorado, Aurora, CO, USA., Lee R; Division of General Internal Medicine, Department of Medicine, University of Colorado, Aurora, CO, USA., Farro S; Division of Geriatric Medicine, Department of Medicine, University of Colorado, Aurora, CO, USA., Loeb D; Division of General Internal Medicine, Department of Medicine, University of Colorado, Aurora, CO, USA., Schifeling C; Division of Geriatric Medicine, Department of Medicine, University of Colorado, Aurora, CO, USA., Huebschmann AG; Division of General Internal Medicine, Department of Medicine, University of Colorado, Aurora, CO, USA.

Publikováno v: Translational behavioral medicine [Transl Behav Med] 2021 Jul 29; Vol. 11 (7), pp. 1339-1347.