Zobrazeno 1 - 10
of 207
pro vyhledávání: '"D D, Breimer"'
Autor:
D D Breimer
Publikováno v:
Pharmaceutical Research. 17:1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aeb31f8fb4edb11c03f9fc9a15f34565
https://doi.org/10.1023/a:1017217104689
https://doi.org/10.1023/a:1017217104689
Publikováno v:
Journal of Neural Transmission. 106:803-818
Memantine is an uncompetitive N-methyl-D-aspartate receptor antagonist which blocks the NMDA receptor with moderate-affinity in a use- and voltage dependent manner. In clinical practice it is used chronically in the treatment of dementia and does not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea0470f49c9ddf7e91a79b38f5bae88
https://doi.org/10.1007/s007020050201
https://doi.org/10.1007/s007020050201
Publikováno v:
Journal of Neural Transmission. 106:409-421
Behavioral changes have previously been reported following administrations of uncompetitive NMDA receptor antagonists memantine, amantadine and MK-801 for 14 days, at the doses that produce plasma levels comparable to those seen in patients (20, 100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f137440338dca9849b5b4abdc25fffc
https://doi.org/10.1007/s007020050168
https://doi.org/10.1007/s007020050168
Publikováno v:
European Journal of Pharmaceutical Sciences. 8:1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfdcf7a91e5bf9641ccf0c980e767ce8
https://doi.org/10.1016/s0928-0987(99)00003-2
https://doi.org/10.1016/s0928-0987(99)00003-2
Publikováno v:
Pharmaceutical Research. 16:637-642
Purpose. To determine free brain concentrations of the clinically used uncompetitive NMDA antagonists memantine and amantadine using microdialysis corrected for in vivo recovery in relations to serum, CSF and brain tissue levels and their in vitro po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0421b357656f635a026f67f29fc4240
https://doi.org/10.1023/a:1018856020583
https://doi.org/10.1023/a:1018856020583
Publikováno v:
Pharmaceutical research. 1(3)
Lidocaine was administered to healthy volunteers at different sites in the rectum. Unchanged drug and monoethylglycinexylidide (MEGX) concentrations were measured in plasma with a newly developed gas chromatographic method. Lidocaine was given rectal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a91fea25f6d58b969b096a5dd953eedf
https://pubmed.ncbi.nlm.nih.gov/24277250
https://pubmed.ncbi.nlm.nih.gov/24277250
Publikováno v:
Pharmaceutical research. 1(4)
The extent of "first-pass" elimination of racemic propranolol and dextropropranolol in doses of 0.25 or 0.50 mg was investigated in relation to the site of drug administration in the rectum of rats. The compounds were given orally, i.v., and rectally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b8d1db714dfdb0ec94d86fe52d5b56b
https://pubmed.ncbi.nlm.nih.gov/24277285
https://pubmed.ncbi.nlm.nih.gov/24277285
Publikováno v:
Pharmaceutical research. 3(3)
Two model substrates for oxidative hepatic enzyme activity, viz. antipyrine (A) and theophylline (T), were given simultaneously to rats by iv administration. Blood concentrations of A and T were measured by a high-performance liquid chromatographic (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::82ebfc9fa58063c4b4af0eab4528fc24
https://pubmed.ncbi.nlm.nih.gov/24271521
https://pubmed.ncbi.nlm.nih.gov/24271521
Autor:
D. D. Breimer, A. L. Van Steveninck, Adam F. Cohen, Rik C. Schoemaker, Bert Tuk, G. Roncari, Ronald Gieschke, M. S. M. Pieters
Publikováno v:
British Journal of Clinical Pharmacology. 41:565-573
1. Interaction between alcohol and bretazenil (a benzodiazepine partial agonist in animals) was studied with diazepam as a comparator in a randomized, double-blind, placebo controlled six-way cross over experiment in 12 healthy volunteers, aged 19-26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1f855b8fd72f982cec9ad59104e967
https://doi.org/10.1046/j.1365-2125.1996.38514.x
https://doi.org/10.1046/j.1365-2125.1996.38514.x
Publikováno v:
Pharmaceutical Research. 12:129-133
The aim of this study was to determine whether changes in the transport of drugs into the brain could be determined by in vivo intracerebral microdialysis. Atenolol was used as a model drug to determine blood-brain barrier (BBB) transport characteris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64a1f085e66f750d8ce97486001113f9
https://doi.org/10.1023/a:1016207208406
https://doi.org/10.1023/a:1016207208406