Zobrazeno 1 - 10 of 93 pro vyhledávání: '"D Cozzetto"'
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DOP71 TREM1, OSM and a co-expressed transcriptional module are core components of the molecular resistome to anti-cytokine therapy in Ulcerative Colitis
Autor: A Saifuddin, M Madgwick, D Cozzetto, P Pavlidis, B Verstockt, A Hart, T Korcsmaros, N Powell
Publikováno v: Journal of Crohn's and Colitis. 17:i146-i148
Background Molecular biomarkers are emerging as promising tools to predict response to advanced therapy in IBD. For instance, mucosal expression of Triggering Receptor Expressed on Myeloid cells-1 (TREM1) and oncostatin M (OSM) are associated with an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04ba120e8033182773a5c46179b1e791
https://doi.org/10.1093/ecco-jcc/jjac190.0111
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2
Akademický článek
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3
Akademický článek
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4
P060 Unravelling the microbial-derived metabolic alterations in a T-bet-/- x RAG2-/- mouse colitis model
Autor: Z Liu, J Lo, J Alexander, D Cozzetto, N Powell
Publikováno v: Journal of Crohn's and Colitis. 16:i168-i171
Background T-bet (Tbx21) is a T-box transcription factor that can regulate immune cells’ differentiation and function. Loss of T-bet leads to the absence of adaptive immunity. T-bet-/- x RAG2-/- mice develop spontaneous ulcerative colitis (TRUC) th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b56e22a1d8735806116cb0ece33ff063
https://doi.org/10.1093/ecco-jcc/jjab232.189
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5
Akademický článek
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6
P070 Global cytokine—cytokine interaction framework to uncover communication channels between elements of the immune system
Autor: M Olbei, D Modos, D Cozzetto, N Powell, T Korcsmaros
Publikováno v: Journal of Crohn's and Colitis. 17:i236-i236
Background Cytokines are small peptides that signal between a variety of cell types and are one of the fundamental communication elements of the immune system. A variety of cytokine—cytokine interactions have previously been investigated in the lit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::997c81c7181e285b034778d1a683510b
https://doi.org/10.1093/ecco-jcc/jjac190.0200
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7
DOP67 A transcriptional module associated with neutrophil degranulation is highly conserved across species and is a core molecular pathway of treatment resistance in ulcerative colitis
Autor: D Cozzetto, J Lo, N Powell
Publikováno v: Journal of Crohn's and Colitis. 17:i144-i144
Background Advanced therapeutics are changing the treatment landscape in ulcerative colitis (UC), but drug resistance is still common. New strategies are needed to identify the molecular and cellular drivers of treatment resistance and inform the dev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d4446708bd99c8c9d6e1bb45bf65d8a
https://doi.org/10.1093/ecco-jcc/jjac190.0107
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8
OP20 Perianal fistulas are characterised by expansion of interleukin-22 producing invariant natural killer T-cells and CD4+ T-cells which drive dysregulation of the extracellular matrix
Autor: L Constable, N Iqbal, D Cozzetto, A Hart, P Tozer, N Powell
Publikováno v: Journal of Crohn's and Colitis. 16:i022-i022
Background Perianal fistulas are a common complication of Crohn’s disease (CD) affecting approximately 25% of patients, often predicting a more complicated disease course. Dysregulated immune responses and epithelial-to-mesenchymal transition (EMT)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffed11dc7b3f2a0f36a8a71931f95329
https://doi.org/10.1093/ecco-jcc/jjab232.019
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9
P001 Immune checkpoint inhibitor-induced colitis is mediated by polyfunctional lymphocytes and is dependent on the IL23/IFNg axis
Autor: J Lo, D Cozzetto, M Madgwick, J Y X S Sieh, M Olbei, J L Alexander, J Miguens Blanco, H Kudo, H Ibraheim, Z Liu, R Castro Seoane, R Goldin, J Marchesi, T Korcsmaros, G Lord, N Powell
Publikováno v: Journal of Crohn's and Colitis. 16:i135-i135
Background Immune checkpoint inhibitors (CPI) have revolutionised cancer treatment, with previously untreatable disease now amenable to potential cure. Combination regimens of anti-CTLA4 and anti-PD-1 show enhanced efficacy but are prone to off targe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f0e653073218a57975a0c475dbb2bcf
https://doi.org/10.1093/ecco-jcc/jjab232.130
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10
P011 New insights into the pathogenic potential and signalling network of NKG2D+ CD4+ T-cells in Crohn’s Disease
Autor: D Modos, L Gul, J Lo, M Madgwick, D Cozzetto, G Lord, T Korcsmaros, N Powell
Publikováno v: Journal of Crohn's and Colitis. 16:i141-i141
Background A subset of mucosal CD4+ T-cells expressing the NK cell receptor NKG2D (encoded by the KLRK1 gene) are enriched in patients with Crohn’s Disease (CD). In pre-clinical models of colitis, NKG2D expression was confined to a subset of coloni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d055af17e6f41350fa78f5a4931bbca
https://doi.org/10.1093/ecco-jcc/jjab232.140
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