Zobrazeno 1 - 10
of 135
pro vyhledávání: '"D Clark Files"'
Autor:
Ian Gordon, Linda Denehy, Amalia Karahalios, D Clark Files, Jennifer R A Jones, Sue Berney, Michael J Berry, David M Griffith, Luke A McDonald, Peter E Morris, Marc Moss, Amy Nordon-Craft, Timothy Walsh, Zudin Puthucheary
Publikováno v:
BMJ Open, Vol 10, Iss 5 (2020)
Introduction The number of inconclusive physical rehabilitation randomised controlled trials for patients with critical illness is increasing. Evidence suggests critical illness patient subgroups may exist that benefit from targeted physical rehabili
Externí odkaz:
https://doaj.org/article/b73a239693d74f2383411d7da96cc6f9
Autor:
Daren K Heyland, Andrew Day, G John Clarke, Catherine (Terri) Hough, D Clark Files, Marina Mourtzakis, Nicolaas Deutz, Dale M Needham, Renee Stapleton
Publikováno v:
BMJ Open, Vol 9, Iss 7 (2019)
Introduction Survivors of critical illness often experience significant morbidities, including muscle weakness and impairments in physical functioning. This muscle weakness is associated with longer duration mechanical ventilation, greater hospital c
Externí odkaz:
https://doaj.org/article/3cc160f312304151a418af2ac070406f
Autor:
Jennifer T. W. Krall, Lanazha Belfield, Claire Strysick, Chun Liu, Lina Purcell, Renee Stapleton, Michael Toth, Matthew Poynter, Xuewei Zhu, Kevin Gibbs, D. Clark Files
Publikováno v:
Physiological Reports, Vol 12, Iss 18, Pp n/a-n/a (2024)
Abstract Skeletal muscle dysfunction in critical illnesses leaves survivors weak and functionally impaired. Macrophages infiltrate muscles; however, their functional role is unclear. We aim to examine muscle leukocyte composition and the effect of ma
Externí odkaz:
https://doaj.org/article/57cf243d82e44c7db1a632a76ed56440
Autor:
D Clark Files, Kunhong Xiao, Tan Zhang, Chun Liu, Jiang Qian, Weiling Zhao, Peter E Morris, Osvaldo Delbono, Xin Feng
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87587 (2014)
Skeletal muscle wasting in acute lung injury (ALI) patients increases the morbidity and mortality associated with this critical illness. The contribution of laryngeal muscle wasting to these outcomes is unknown, though voice impairments and aspiratio
Externí odkaz:
https://doaj.org/article/4aaed548963f4283840d6fdb3543d892
Autor:
Hollis R. O’Neal, Jr, MD, MSc, Roya Sheybani, PhD, David R. Janz, MD, MSc, Robert Scoggins, MD, PhD, Tonya Jagneaux, MD, James E. Walker, MD, PhD, Daniel J. Henning, MD, MPH, Elizabeth Rosenman, MD, Simon A. Mahler, MD, MS, Hariharan Regunath, MD, Christopher S. Sampson, MD, D. Clark Files, MD, Richard D. Fremont, MD, Michael J. Noto, MD, PhD, Erica E. Schneider, MD, Wesley R. Shealey, MD, Matthew S. Berlinger, MD, Thomas C. Carver, MD, Morgan K. Walker, MD, Nathan A. Ledeboer, PhD, Ajay M. Shah, PhD, Henry T.K. Tse, PhD, Dino DiCarlo, PhD, Todd W. Rice, MD, MSc, Christopher B. Thomas, MD
Publikováno v:
Critical Care Explorations, Vol 6, Iss 2, p e1026 (2024)
OBJECTIVES:. To assess the in vitro IntelliSep test, a microfluidic assay that quantifies the state of immune activation by evaluating the biophysical properties of leukocytes, as a rapid diagnostic for sepsis. DESIGN:. Prospective cohort study. SETT
Externí odkaz:
https://doaj.org/article/63538c9b3c63401cb6b64ae711591b01
Autor:
Philip Yang, MD, MSc, Neal W. Dickert, MD, PhD, Angela Haczku, MD, PhD, Christine Spainhour, RN, CCRC, Sara C. Auld, MD, MSc, the I-SPY COVID Consortium, Neil R. Aggarwal, MD, MHSc, Timothy Albertson, MD, Sara Auld, MD, Jeremy R. Beitler, MD, MPH, Paul Berger, DO, Ellen L. Burnham, MD, Carolyn S. Calfee, MD, MAS, Nathan Cobb, MD, Alessio Crippa, PhD, Andrea Discacciati, PhD, Martin Eklund, PhD, Laura Esserman, MD, MBA, D. Clark Files, MD, Eliot Friedman, MD, Sheetal Gandotra, MD, Kashif Khan, MD, Jonathan Koff, MD, Santhi Kumar, MD, Kathleen D. Liu, MD, PhD, Thomas R. Martin, MD, Michael A. Matthay, MD, Nuala J. Meyer, MD, Timothy Obermiller, MD, MS, Philip Robinson, MD, Derek Russell, MD, Karl Thomas, MD, Se Fum Wong, MD, Richard G. Wunderink, MD, Mark M. Wurfel, PhD, MD, Albert Yen, MD, Fady A. Youssef, MD, Anita Darmanian, MD, Amy L. Dzierba, PharmD, Ivan Garcia, RRT, Katarzyna Gosek, PharmD, Purnema Madahar, MD, MS, Aaron M. Mittel, MD, Justin Muir, PharmD, Amanda Roden, MD, John Schicchi, MD, Alexis L. Serra, MD, MPH, Romina Wahab, MD, Kevin W. Gibbs, MD, Leigha Landreth, RN, Mary LaRose, RN, Lisa Parks, RN, Adina Wynn, MPH, CCRP, Caroline A. G. Ittner, PhD, Nilam S. Mangalmurti, MD, John P. Reilly, MD, MS, Donna Harris, BSN, Abhishek Methukupally, MBBS, Siddharth Patel, MBBS, MPH, Lindsie Boerger, BA, John Kazianis, MD, Carrie Higgins, Jeff McKeehan, MS, Brian Daniel, RCP, RRT, Scott Fields, PharmD, James Hurst-Hopf, MS, Alejandra Jauregui, BA, Lamorna Brown Swigart, PhD, Daniel Belvins, CCRP, Catherine Nguyen, MD, Alexis Suarez, MS, Maged A. Tanios, MD, Farjad Sarafian, MD, Usman Shah, MD, Max Adelman, MD, MSc, Christina Creel-Bulos, MD, Joshua Detelich, MD, Gavin Harris, MD, Katherine Nugent, MD, Philip Yang, MD, Erin Hardy, Richart Harper, MD, Brian Morrissey, MD, Christian Sandrock, MD, MPH, G. R. Scott Budinger, MD, Helen K. Donnelly, RN, BSN, Benjamin D. Singer, MD, Ari Moskowitz, MD, Melissa Coleman, MD, Joseph Levitt, MD, Ruixiao Lu, PhD, Paul Henderson, PhD, Adam Asare, PhD, Imogene Dunn, PhD, Alejandro Botello Barragan
Publikováno v:
Critical Care Explorations, Vol 5, Iss 6, p e0930 (2023)
OBJECTIVES:. To analyze the temporal trend in enrollment rates in a COVID-19 platform trial during the first three waves of the pandemic in the United States. DESIGN:. Secondary analysis of data from the I-SPY COVID randomized controlled trial (RCT).
Externí odkaz:
https://doaj.org/article/7af4c25ca81249e2a0432daa16bb510e
Autor:
Li Wang, Markus H. Kainulainen, Nannan Jiang, Han Di, Gaston Bonenfant, Lisa Mills, Michael Currier, Punya Shrivastava-Ranjan, Brenda M. Calderon, Mili Sheth, Brian R. Mann, Jaber Hossain, Xudong Lin, Sandra Lester, Elizabeth A. Pusch, Joyce Jones, Dan Cui, Payel Chatterjee, M. Harley Jenks, Esther K. Morantz, Gloria P. Larson, Masato Hatta, Jennifer L. Harcourt, Azaibi Tamin, Yan Li, Ying Tao, Kun Zhao, Kristine Lacek, Ashley Burroughs, Wei Wang, Malania Wilson, Terianne Wong, So Hee Park, Suxiang Tong, John R. Barnes, Mark W. Tenforde, Wesley H. Self, Nathan I. Shapiro, Matthew C. Exline, D. Clark Files, Kevin W. Gibbs, David N. Hager, Manish Patel, Alison L. Halpin, Laura K. McMullan, Justin S. Lee, Hongjie Xia, Xuping Xie, Pei-Yong Shi, C. Todd Davis, Christina F. Spiropoulou, Natalie J. Thornburg, M. Steven Oberste, Vivien G. Dugan, SSEV Bioinformatics Working Group, David E. Wentworth, Bin Zhou
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Emerging SARS-CoV-2 variants raise concerns on immune evasion. Here, the authors evaluate the neutralization efficiency of COVID-19 mRNA vaccinee sera against representative viruses of 13 WHO-designated SARS-CoV-2 variants of concern/interest.
Externí odkaz:
https://doaj.org/article/84e63a00491642b6b45810225eb5bbbf
Autor:
D. Clark Files, Neil Aggarwal, Timothy Albertson, Sara Auld, Jeremy R. Beitler, Paul Berger, Ellen L. Burnham, Carolyn S. Calfee, Nathan Cobb, Alessio Crippa, Andrea Discacciati, Martin Eklund, Laura Esserman, Eliot Friedman, Sheetal Gandotra, Kashif Khan, Jonathan Koff, Santhi Kumar, Kathleen D. Liu, Thomas R. Martin, Michael A. Matthay, Nuala J. Meyer, Timothy Obermiller, Philip Robinson, Derek Russell, Karl Thomas, Se Fum Wong, Richard G. Wunderink, Mark M. Wurfel, Albert Yen, Fady A. Youssef, Anita Darmanian, Amy L. Dzierba, Ivan Garcia, Katarzyna Gosek, Purnema Madahar, Aaron M. Mittel, Justin Muir, Amanda Rosen, John Schicchi, Alexis L. Serra, Romina Wahab, Kevin W. Gibbs, Leigha Landreth, Mary LaRose, Lisa Parks, Adina Wynn, Caroline A.G. Ittner, Nilman S. Mangalmurti, John P. Reilly, Donna Harris, Abhishek Methukupally, Siddharth Patel, Lindsie Boerger, John Kazianis, Carrie Higgins, Jeff McKeehan, Brian Daniel, Scott Fields, James Hurst-Hopf, Alejandra Jauregui, Lamorna Brown Swigart, Daniel Blevins, Catherine Nguyen, Alexis Suarez, Maged A. Tanios, Farjad Sarafian, Usman Shah, Max Adelman, Christina Creel-Bulos, Joshua Detelich, Gavin Harris, Katherine Nugent, Christina Spainhour, Philip Yang, Angela Haczku, Erin Hardy, Richart Harper, Brian Morrissey, Christian Sandrock, G. R. Scott Budinger, Helen K. Donnelly, Benjamin D. Singer, Ari Moskowitz, Melissa Coleman, Joseph Levitt, Ruixiao Lu, Paul Henderson, Adam Asare, Imogene Dunn, Alejandro Botello Barragan
Publikováno v:
EClinicalMedicine, Vol 58, Iss , Pp 101889- (2023)
Summary: Background: An urgent need exists to rapidly screen potential therapeutics for severe COVID-19 or other emerging pathogens associated with high morbidity and mortality. Methods: Using an adaptive platform design created to rapidly evaluate i
Externí odkaz:
https://doaj.org/article/455f6804c6664df29b7f69d1279558b0
Autor:
Andrew J. Goodwin, MD, MSCR, Daniel L. Brinton, PhD, Charles Terry, MD, MSCR, George Carter, MD, D. Clark Files, MD, Katie Kirchoff, MS, Dee W. Ford, MD, MSCR, Annie N. Simpson, PhD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 3, p e0877 (2023)
OBJECTIVES:. Emerging evidence suggests the potential importance of inspiratory driving pressure (DP) and respiratory system elastance (ERS) on outcomes among patients with the acute respiratory distress syndrome. Their association with outcomes amon
Externí odkaz:
https://doaj.org/article/df34f72b2c7e4d9d9e99611b8ff80be8
Autor:
Charles Terry, MD, MSCR, Daniel Brinton, PhD, Annie N. Simpson, PhD, Katie Kirchoff, MS, D. Clark Files, MD, George Carter, MD, Dee W. Ford, MD, MSCR, Andrew J. Goodwin, MD, MSCR
Publikováno v:
Critical Care Explorations, Vol 4, Iss 12, p e0811 (2022)
Importance:. Existing recommendations for mechanical ventilation are based on studies that under-sampled or excluded obese and severely obese individuals. Objective:. To determine if driving pressure (DP) and total respiratory system elastance (Ers)
Externí odkaz:
https://doaj.org/article/33f1406485034064a28c4b46ec7bd672