Zobrazeno 1 - 10
of 314
pro vyhledávání: '"D Christophe"'
Autor:
Genevieve McCluskey, Marco Heestermans, Ivan Peyron, Eloise Pascal, Marie Clavel, Eric Bun, Emilie Bocquet, Christelle Reperant, Sophie Susen, Olivier D. Christophe, Cecile V. Denis, Peter J. Lenting, Caterina Casari
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Patients suffering from von Willebrand disease (VWD) have reduced quality-of-life despite current treatment options. Moreover, innovation in VWD therapeutic strategies has essentially stalled and available treatments have remained unchanged for decad
Externí odkaz:
https://doaj.org/article/a42d4108425e40568ec708926fcce4bb
Autor:
Claire Kizlik-Masson, Ivan Peyron, Stéphane Gangnard, Gaelle Le Goff, Solen M Lenoir, Sandra Damodaran, Marie Clavel, Stéphanie Roullet, Véronique Regnault, Antoine Rauch, Flavien Vincent, Emmanuelle Jeanpierre, Annabelle Dupont, Catherine Ternisien, Thibault Donnet, Olivier D. Christophe, Eric van Belle, Cécile V. Denis, Caterina Casari, Sophie Susen, Peter J. Lenting
Publikováno v:
Blood. 141:1457-1468
von Willebrand factor (VWF) is a multimeric protein, the size of which is regulated via ADAMTS13-mediated proteolysis within the A2 domain. We aimed to isolate nanobodies distinguishing between proteolyzed and non-proteolyzed VWF, leading to the iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0b0aaea43a2a21d8812e80dcc982c3e
https://doi.org/10.1182/blood.2022017569
https://doi.org/10.1182/blood.2022017569
Autor:
Josepha C. Sedzro, Frédéric Adam, Claire Auditeau, Elsa Bianchini, Allan De Carvalho, Ivan Peyron, Sadyo Daramé, Sophie Gandrille, Stella Thomassen, Tilman M. Hackeng, Olivier D. Christophe, Peter J. Lenting, Cécile V. Denis, Delphine Borgel, François Saller
Publikováno v:
Journal of Thrombosis and Haemostasis, 20(7), 1653-1664. Wiley
BACKGROUND: Protein S (PS) is a natural anticoagulant acting as a cofactor for activated protein C (APC) in the proteolytic inactivation of activated factor V (FVa) and VIII (FVIIIa), but also for tissue factor pathway inhibitor α (TFPIα) in the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928d5f32b4411f3f25b16f4e1a2242bf
https://doi.org/10.1111/jth.15736
https://doi.org/10.1111/jth.15736
Autor:
Stéphanie Roullet, Norman Luc, Julie Rayes, Jean Solarz, Dante Disharoon, Andrew J Ditto, Emily Gahagan, Christa Pawlowski, Thibaud Sefiane, Frédéric Adam, Caterina Casari, Olivier D. Christophe, Michael A Bruckman, Peter J Lenting, Anirban Sen Gupta, Cecile V Denis
Publikováno v:
Blood.
The lack of innovation in Von Willebrand disease (VWD) originates from many factors including the complexity and heterogeneity of the disease but also from a lack of recognition of the impact of the bleeding symptoms experienced by VWD patients. Rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::249de84cf089dcb567517a220c454c68
https://doi.org/10.1182/blood.2022018956
https://doi.org/10.1182/blood.2022018956
Autor:
C Steichen, T. Lambert, Anne Dubart-Kupperschmitt, J M Heslan, Antonietta Messina, E. Luce, M Allouche, Olivier D. Christophe, Anne Weber, Tuan Huy Nguyen
Publikováno v:
Hepatology. 75:866-880
Pluripotent stem cell-derived hepatocytes differentiated in monolayer culture are known to have more fetal than adult hepatocyte characteristics. If numerous studies tend to show that this immature phenotype might not necessarily be an obstacle to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4d74c4735441352bb167752fda3259
https://doi.org/10.1002/hep.32211
https://doi.org/10.1002/hep.32211
Autor:
Chinaemerem U. Onyishi, Guillaume E. Desanti, Alex L. Wilkinson, Gyorgy Fejer, Olivier D. Christophe, Clare E. Bryant, Subhankar Mukhopadhyay, Siamon Gordon, Robin C. May
The opportunistic fungal pathogenCryptococcus neoformanscauses lethal infections in immunocompromised patients. Macrophages are central to the host response to cryptococci; however, it is unclear howC. neoformansis recognized and phagocytosed by macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c336b0aeb8af34d7dd8ab55ba1cfbf17
https://doi.org/10.1101/2023.01.30.525903
https://doi.org/10.1101/2023.01.30.525903
Autor:
Claire, Kizlik-Masson, Ivan, Peyron, Stéphane, Gangnard, Gaelle Claire, Le Goff, Solen, Lenoir, Sandra, Damodaran, Marie, Clavel, Stéphanie, Roullet, Veronique, Regnault, Antoine, Rauch, Flavien, Vincent, Emmanuelle, Jeanpierre, Annabelle, Dupont, Catherine, Ternisien, Thibault, Donnet, Olivier D, Christophe, Eric, Van Belle, Cecile V, Denis, Caterina, Casari, Sophie, Susen, Peter J, Lenting
Publikováno v:
Blood.
Von Willebrand factor (VWF) is a multimeric protein, the size of which is regulated via ADAMTS13-mediated proteolysis within the A2-domain. We aimed to isolate nanobodies distinguishing between proteolyzed and non-proteolyzed VWF, leading to the iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::82299747c7221b478ce51a20b25af48a
https://pubmed.ncbi.nlm.nih.gov/36564031
https://pubmed.ncbi.nlm.nih.gov/36564031
Autor:
Paulette Legendre, Melusine Didelot, Jeremy Lagrange, Olivier D. Christophe, Vincent Muczynski, Morel E Worou, Cécile V. Denis, Guillaume Gauchotte, Patrick Lacolley, François Plénat, Alexandre Raoul, Peter J. Lenting, Véronique Regnault, Jean-Baptiste Michel, Marc-Damien Lourenco-Rodrigues
Publikováno v:
Cardiovascular Research
Cardiovascular Research, Oxford University Press (OUP), 2021, ⟨10.1093/cvr/cvab042⟩
Cardiovascular Research, Oxford University Press (OUP), 2022, 118 (2), pp.622-637. ⟨10.1093/cvr/cvab042⟩
Cardiovascular Research, 2022, 118 (2), pp.622-637. ⟨10.1093/cvr/cvab042⟩
Cardiovascular Research, Oxford University Press (OUP), 2021, ⟨10.1093/cvr/cvab042⟩
Cardiovascular Research, Oxford University Press (OUP), 2022, 118 (2), pp.622-637. ⟨10.1093/cvr/cvab042⟩
Cardiovascular Research, 2022, 118 (2), pp.622-637. ⟨10.1093/cvr/cvab042⟩
Aims Von Willebrand factor (VWF) is a plasma glycoprotein involved in primary hemostasis, while also having additional roles beyond hemostasis namely in cancer, inflammation, angiogenesis and potentially in vascular smooth muscle cell (VSMC) prolifer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01c57f08db62e0fc8572da79b1b665b
https://doi.org/10.1093/cvr/cvab042
https://doi.org/10.1093/cvr/cvab042
Autor:
Vincent Muczynski, Angel Smith, Thibaud Sefiane, Olivier D. Christophe, Peter J. Lenting, David Granger, Kerry Chester, Amit C. Nathwani
Publikováno v:
Blood. 140:677-678
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fd0f8526bc9bbbe27aea962c7748f66
https://doi.org/10.1182/blood-2022-169482
https://doi.org/10.1182/blood-2022-169482
Development of a dual hybrid AAV vector for endothelial-targeted expression of von Willebrand factor
Autor:
Federico Mingozzi, Caterina Casari, Aboud Sakkal, Peter J. Lenting, Cécile V. Denis, Charlotte Kawecki, Severine Charles, Elena Barbon, Giuseppe Ronzitti, Solenne Marmier, Olivier D. Christophe, Fanny Collaud
Publikováno v:
Gene Therapy. 30:245-254
Von Willebrand disease (VWD), the most common inherited bleeding disorder in humans, is caused by quantitative or qualitative defects in von Willebrand factor (VWF). VWD represents a potential target for gene therapy applications, as a single treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3942f39dafbece3802909ed0c03468
https://doi.org/10.1038/s41434-020-00218-6
https://doi.org/10.1038/s41434-020-00218-6